S1P3 receptor (s1pr3_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P3 receptor

GENE

S1pr3 (Edg3, Lpb3)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Sphingosine 1-phosphate receptor 3, S1P receptor 3, S1P3, Endothelial differentiation G-protein coupled receptor 3, Lysophospholipid receptor B3, Sphingosine 1-phosphate receptor Edg-3, S1P receptor Edg-3

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
T
T
H
A
Q
G
H
Q
10
                   
P
V
L
G
N
D
T
L
R
E
20
                   
H
Y
D
Y
V
G
K
L
A
G
30
                   
R
L
R
D
P
P
E
G
G
T
40
TM1              
L
I
T
T
I
L
F
L
V
T
50
                   
C
S
F
I
V
L
E
N
L
M
60
                   
V
L
I
A
I
W
K
N
N
K
70
ICL1 TM2      
F
H
N
R
M
Y
F
F
I
G
80
                   
N
L
A
L
C
D
L
L
A
G
90
                   
I
A
Y
K
V
N
I
L
M
S
100
ECL1       TM3
G
R
K
T
F
S
L
S
P
T
110
                   
V
W
F
L
R
E
G
S
M
F
120
                   
V
A
L
G
A
S
T
C
S
L
130
                   
L
A
I
A
I
E
R
H
L
T
140
      ICL2      
M
I
K
M
R
P
Y
D
A
N
150
TM4              
K
K
H
R
V
F
L
L
I
G
160
                   
M
C
W
L
I
A
F
S
L
G
170
            ECL2
A
L
P
I
L
G
W
N
C
L
180
                   
E
N
F
P
D
C
S
T
I
L
190
      TM5        
P
L
Y
S
K
K
Y
I
A
F
200
                   
L
I
S
I
F
T
A
I
L
V
210
                   
T
I
V
I
L
Y
A
R
I
Y
220
                   
C
L
V
K
S
S
S
R
R
V
230
TM6              
A
N
H
N
S
E
R
S
M
A
240
                   
L
L
R
T
V
V
I
V
V
S
250
                   
V
F
I
A
C
W
S
P
L
F
260
                   
I
L
F
L
I
D
V
A
C
R
270
ECL3 TM7      
A
K
E
C
S
I
L
F
K
S
280
                   
Q
W
F
I
M
L
A
V
L
N
290
                   
S
A
M
N
P
V
I
Y
T
L
300
  H8              
A
S
K
E
M
R
R
A
F
F
310
        C-term
R
L
V
C
G
C
L
V
K
G
320
                   
K
G
T
Q
A
S
P
M
Q
P
330
                   
A
L
D
P
S
R
S
K
S
S
340
                   
S
S
N
N
S
S
H
S
P
K
350
                   
V
K
E
D
L
P
R
V
A
T
360
                   
S
S
C
I
I
D
K
N
R
S
370
               
F
Q
N
G
V
L
C
K

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 N K F H ICL1ECL1 G R K T F S L ECL1ICL2 M R P Y D A N ICL2ECL2 W N C L E N F P D C S T I L P L Y ECL2ICL3 V ICL3ECL3 R A K E C ECL3N-term M A T T H A Q G H Q P V L G N D T L R E H Y D Y V G K L A G R L R D P P E G G N-termC-term G C L V K G K G T Q A S P M Q P A L D P S R S K S S S S N N S S H S P K V K E D L P R V A T S S C I I D K N R S F Q N G V L C K C-term T L I T T I L F L V T C S F I V L E N L M V L I A I W K N N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K K K H R V F L L I G M C W L I A F S L G A L P I L G S K K Y I A F L I S I F T A I L V T I V I L Y A R I Y C L V K S S S R R A N H N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C S I L F K S Q W F I M L A V L N S A M N P V I Y T L A S K E F F R M R R A L V C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V I F S C T V L F L I T T I L T 1 G N L A L C D L L A G I A Y K V N I L M 2 A L L S C T S A G L A V F M S G E R L F 3 V F L L I G M C W L I A F S L G A L P I 4 Y L I V I T V L I A T F I S I L F A I Y 5 V I V V S V F I A C W S P L F I L F L I 6 V P N M A S N L V A L M I F W Q S K F 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

sphingosine 1-phosphate

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available