MRGPRX1 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8DWC

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-022-01173-6

PUBLICATION DATE

Nov. 2, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

Proenkephalin-A - Agonist

ENDOGENOUS LIGANDS

bovine adrenal medulla peptide 8-22



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
S 123 3x53 TM3 N 239 G.h2s4.02 polar
S 123 3x53 TM3 N 239 G.h2s4.02 hydrophobic
S 123 3x53 TM3 N 239 G.h2s4.02 van-der-waals
L 214 6x33 TM6 L 245 G.S4.03 polar
L 214 6x33 TM6 L 245 G.S4.03 hydrophobic
C 132 34x55 ICL2 R 32 G.HN.49 hydrophobic
H 133 34x56 ICL2 R 32 G.HN.49 polar
H 133 34x56 ICL2 R 32 G.HN.49 hydrophobic
H 133 34x56 ICL2 R 32 G.HN.49 van-der-waals
R 131 34x54 ICL2 M 238 G.h2s4.01 hydrophobic
R 131 34x54 ICL2 M 238 G.h2s4.01 van-der-waals
V 124 3x54 TM3 L 236 G.H2.09 hydrophobic
V 124 3x54 TM3 L 236 G.H2.09 van-der-waals
P 127 34x50 ICL2 N 239 G.h2s4.02 polar
L 214 6x33 TM6 L 240 G.h2s4.03 hydrophobic
F 61 2x39 TM2 Y 243 G.S4.01 aromatic
F 61 2x39 TM2 Y 243 G.S4.01 hydrophobic
F 61 2x39 TM2 Y 243 G.S4.01 van-der-waals
F 61 2x39 TM2 E 242 G.h2s4.05 hydrophobic
F 61 2x39 TM2 E 242 G.h2s4.05 van-der-waals
G 276 7x57 TM7 N 244 G.S4.02 hydrophobic
G 276 7x57 TM7 N 244 G.S4.02 van-der-waals
R 131 34x54 ICL2 I 235 G.H2.08 hydrophobic
R 131 34x54 ICL2 I 235 G.H2.08 van-der-waals
N 59 2x37 TM2 E 242 G.h2s4.05 hydrophobic
I 128 34x51 ICL2 I 235 G.H2.08 hydrophobic
R 213 6x32 TM6 L 245 G.S4.03 hydrophobic
R 213 6x32 TM6 L 245 G.S4.03 van-der-waals
T 136 4x39 TM4 R 31 G.HN.48 hydrophobic
T 136 4x39 TM4 R 31 G.HN.48 van-der-waals
Y 130 34x53 ICL2 N 239 G.h2s4.02 hydrophobic
R 120 3x50 TM3 Y 243 G.S4.01 hydrophobic
I 218 6x37 TM6 L 245 G.S4.03 hydrophobic
P 127 34x50 ICL2 K 232 G.H2.05 hydrophobic
Y 130 34x53 ICL2 E 242 G.h2s4.05 polar
Y 130 34x53 ICL2 E 242 G.h2s4.05 hydrophobic
Y 130 34x53 ICL2 E 242 G.h2s4.05 van-der-waals
Y 130 34x53 ICL2 Y 243 G.S4.01 polar
Y 130 34x53 ICL2 Y 243 G.S4.01 hydrophobic
Y 130 34x53 ICL2 Y 243 G.S4.01 van-der-waals
C 132 34x55 ICL2 R 31 G.HN.48 polar
C 132 34x55 ICL2 R 31 G.HN.48 hydrophobic
C 132 34x55 ICL2 R 31 G.HN.48 van-der-waals
P 127 34x50 ICL2 I 235 G.H2.08 hydrophobic
P 127 34x50 ICL2 I 235 G.H2.08 van-der-waals
C 132 34x55 ICL2 L 34 G.HN.51 hydrophobic
I 128 34x51 ICL2 V 79 G.h1ha.15 hydrophobic
P 127 34x50 ICL2 L 236 G.H2.09 hydrophobic
V 124 3x54 TM3 L 240 G.h2s4.03 hydrophobic
V 124 3x54 TM3 L 240 G.h2s4.03 van-der-waals
R 120 3x50 TM3 L 245 G.S4.03 hydrophobic
E 119 3x49 TM3 Y 243 G.S4.01 polar
E 119 3x49 TM3 Y 243 G.S4.01 hydrophobic
I 128 34x51 ICL2 K 232 G.H2.05 hydrophobic
I 128 34x51 ICL2 F 228 G.H2.01 hydrophobic
I 128 34x51 ICL2 F 228 G.H2.01 van-der-waals
Y 272 7x53 TM7 N 244 G.S4.02 polar
Y 272 7x53 TM7 N 244 G.S4.02 van-der-waals
T 217 6x36 TM6 L 245 G.S4.03 hydrophobic
S 123 3x53 TM3 Y 243 G.S4.01 hydrophobic
S 123 3x53 TM3 Y 243 G.S4.01 van-der-waals
R 134 34x57 ICL2 R 31 G.HN.48 polar
R 134 34x57 ICL2 R 31 G.HN.48 hydrophobic
R 134 34x57 ICL2 R 31 G.HN.48 van-der-waals
L 198 5x61 TM5 L 245 G.S4.03 hydrophobic