μ receptor (oprm_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Opioid receptors μ receptor
GENE
Oprm1 (Ror-b)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Mu-type opioid receptor, M-OR-1, MOR-1, Opioid receptor B
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
S
|
S
|
T
|
G
|
P
|
G
|
N
|
T
|
10 |
S
|
D
|
C
|
S
|
D
|
P
|
L
|
A
|
Q
|
A
|
20 |
S
|
C
|
S
|
P
|
A
|
P
|
G
|
S
|
W
|
L
|
30 |
N
|
L
|
S
|
H
|
V
|
D
|
G
|
N
|
Q
|
S
|
40 |
D
|
P
|
C
|
G
|
L
|
N
|
R
|
T
|
G
|
L
|
50 |
G
|
G
|
N
|
D
|
S
|
L
|
C
|
P
|
Q
|
T
|
60 |
TM1 | |||||||||
G
|
S
|
P
|
S
|
M
|
V
|
T
|
A
|
I
|
T
|
70 |
I
|
M
|
A
|
L
|
Y
|
S
|
I
|
V
|
C
|
V
|
80 |
V
|
G
|
L
|
F
|
G
|
N
|
F
|
L
|
V
|
M
|
90 |
ICL1 | |||||||||
Y
|
V
|
I
|
V
|
R
|
Y
|
T
|
K
|
M
|
K
|
100 |
TM2 | |||||||||
T
|
A
|
T
|
N
|
I
|
Y
|
I
|
F
|
N
|
L
|
110 |
A
|
L
|
A
|
D
|
A
|
L
|
A
|
T
|
S
|
T
|
120 |
L
|
P
|
F
|
Q
|
S
|
V
|
N
|
Y
|
L
|
M
|
130 |
ECL1 | TM3 | ||||||||
G
|
T
|
W
|
P
|
F
|
G
|
T
|
I
|
L
|
C
|
140 |
K
|
I
|
V
|
I
|
S
|
I
|
D
|
Y
|
Y
|
N
|
150 |
M
|
F
|
T
|
S
|
I
|
F
|
T
|
L
|
C
|
T
|
160 |
M
|
S
|
V
|
D
|
R
|
Y
|
I
|
A
|
V
|
C
|
170 |
ICL2 | |||||||||
H
|
P
|
V
|
K
|
A
|
L
|
D
|
F
|
R
|
T
|
180 |
TM4 | |||||||||
P
|
R
|
N
|
A
|
K
|
I
|
V
|
N
|
V
|
C
|
190 |
N
|
W
|
I
|
L
|
S
|
S
|
A
|
I
|
G
|
L
|
200 |
ECL2 | |||||||||
P
|
V
|
M
|
F
|
M
|
A
|
T
|
T
|
K
|
Y
|
210 |
R
|
Q
|
G
|
S
|
I
|
D
|
C
|
T
|
L
|
T
|
220 |
TM5 | |||||||||
F
|
S
|
H
|
P
|
T
|
W
|
Y
|
W
|
E
|
N
|
230 |
L
|
L
|
K
|
I
|
C
|
V
|
F
|
I
|
F
|
A
|
240 |
F
|
I
|
M
|
P
|
V
|
L
|
I
|
I
|
T
|
V
|
250 |
C
|
Y
|
G
|
L
|
M
|
I
|
L
|
R
|
L
|
K
|
260 |
ICL3 | TM6 | ||||||||
S
|
V
|
R
|
M
|
L
|
S
|
G
|
S
|
K
|
E
|
270 |
K
|
D
|
R
|
N
|
L
|
R
|
R
|
I
|
T
|
R
|
280 |
M
|
V
|
L
|
V
|
V
|
V
|
A
|
V
|
F
|
I
|
290 |
V
|
C
|
W
|
T
|
P
|
I
|
H
|
I
|
Y
|
V
|
300 |
ECL3 | |||||||||
I
|
I
|
K
|
A
|
L
|
I
|
T
|
I
|
P
|
E
|
310 |
TM7 | |||||||||
T
|
T
|
F
|
Q
|
T
|
V
|
S
|
W
|
H
|
F
|
320 |
C
|
I
|
A
|
L
|
G
|
Y
|
T
|
N
|
S
|
C
|
330 |
L
|
N
|
P
|
V
|
L
|
Y
|
A
|
F
|
L
|
D
|
340 |
H8 | |||||||||
E
|
N
|
F
|
K
|
R
|
C
|
F
|
R
|
E
|
F
|
350 |
C-term | |||||||||
C
|
I
|
P
|
T
|
S
|
S
|
T
|
I
|
E
|
Q
|
360 |
Q
|
N
|
S
|
T
|
R
|
V
|
R
|
Q
|
N
|
T
|
370 |
R
|
E
|
H
|
P
|
S
|
T
|
A
|
N
|
T
|
V
|
380 |
D
|
R
|
T
|
N
|
H
|
Q
|
L
|
E
|
N
|
L
|
390 |
E
|
A
|
E
|
T
|
A
|
P
|
L
|
P
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
[Met]enkephalin
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available