EP3 receptor (pe2r3_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP3 receptor
GENE
Ptger3 (Ptgerep3)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Prostaglandin E2 receptor EP3 subtype, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, Prostanoid EP3 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
M
|
W
|
A
|
P
|
E
|
H
|
S
|
10 |
A
|
E
|
A
|
H
|
S
|
N
|
L
|
S
|
S
|
T
|
20 |
T
|
D
|
D
|
C
|
G
|
S
|
V
|
S
|
V
|
A
|
30 |
TM1 | |||||||||
F
|
P
|
I
|
T
|
M
|
M
|
V
|
T
|
G
|
F
|
40 |
V
|
G
|
N
|
A
|
L
|
A
|
M
|
L
|
L
|
V
|
50 |
ICL1 | |||||||||
S
|
R
|
S
|
Y
|
R
|
R
|
R
|
E
|
S
|
K
|
60 |
TM2 | |||||||||
R
|
K
|
K
|
S
|
F
|
L
|
L
|
C
|
I
|
G
|
70 |
W
|
L
|
A
|
L
|
T
|
D
|
L
|
V
|
G
|
Q
|
80 |
L
|
L
|
T
|
S
|
P
|
V
|
V
|
I
|
L
|
V
|
90 |
ECL1 | |||||||||
Y
|
L
|
S
|
Q
|
R
|
R
|
W
|
E
|
Q
|
L
|
100 |
TM3 | |||||||||
D
|
P
|
S
|
G
|
R
|
L
|
C
|
T
|
F
|
F
|
110 |
G
|
L
|
T
|
M
|
T
|
V
|
F
|
G
|
L
|
S
|
120 |
S
|
L
|
L
|
V
|
A
|
S
|
A
|
M
|
A
|
V
|
130 |
E
|
R
|
A
|
L
|
A
|
I
|
R
|
A
|
P
|
H
|
140 |
ICL2 | TM4 | ||||||||
W
|
Y
|
A
|
S
|
H
|
M
|
K
|
T
|
R
|
A
|
150 |
T
|
P
|
V
|
L
|
L
|
G
|
V
|
W
|
L
|
S
|
160 |
V
|
L
|
A
|
F
|
A
|
L
|
L
|
P
|
V
|
L
|
170 |
ECL2 | |||||||||
G
|
V
|
G
|
R
|
Y
|
S
|
V
|
Q
|
W
|
P
|
180 |
G
|
T
|
W
|
C
|
F
|
I
|
S
|
T
|
G
|
P
|
190 |
A
|
G
|
N
|
E
|
T
|
D
|
P
|
A
|
R
|
E
|
200 |
TM5 | |||||||||
P
|
G
|
S
|
V
|
A
|
F
|
A
|
S
|
A
|
F
|
210 |
A
|
C
|
L
|
G
|
L
|
L
|
A
|
L
|
V
|
V
|
220 |
T
|
F
|
A
|
C
|
N
|
L
|
A
|
T
|
I
|
K
|
230 |
A
|
L
|
V
|
S
|
R
|
C
|
R
|
A
|
K
|
A
|
240 |
ICL3 | TM6 | ||||||||
A
|
V
|
S
|
Q
|
S
|
S
|
A
|
Q
|
W
|
G
|
250 |
R
|
I
|
T
|
T
|
E
|
T
|
A
|
I
|
Q
|
L
|
260 |
M
|
G
|
I
|
M
|
C
|
V
|
L
|
S
|
V
|
C
|
270 |
W
|
S
|
P
|
L
|
L
|
I
|
M
|
M
|
L
|
K
|
280 |
M
|
I
|
F
|
N
|
Q
|
M
|
S
|
V
|
E
|
Q
|
290 |
ECL3 | TM7 | ||||||||
C
|
K
|
T
|
Q
|
M
|
G
|
K
|
E
|
K
|
E
|
300 |
C
|
N
|
S
|
F
|
L
|
I
|
A
|
V
|
R
|
L
|
310 |
A
|
S
|
L
|
N
|
Q
|
I
|
L
|
D
|
P
|
W
|
320 |
H8 | |||||||||
V
|
Y
|
L
|
L
|
L
|
R
|
K
|
I
|
L
|
L
|
330 |
R
|
K
|
F
|
C
|
Q
|
I
|
R
|
D
|
H
|
T
|
340 |
N
|
Y
|
A
|
S
|
S
|
S
|
T
|
S
|
L
|
P
|
350 |
C-term | |||||||||
C
|
P
|
G
|
S
|
S
|
A
|
L
|
M
|
W
|
S
|
360 |
D
|
Q
|
L
|
E
|
R
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGE2, PGE1, PGD2
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available