TAAR2 (taar2_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans TAAR2
GENE
TAAR2 (GPR58)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Trace amine-associated receptor 2, TaR-2, Trace amine receptor 2, G-protein coupled receptor 58
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
V
|
S
|
S
|
E
|
Q
|
H
|
E
|
L
|
10 |
S
|
H
|
F
|
K
|
R
|
T
|
Q
|
T
|
K
|
K
|
20 |
E
|
K
|
F
|
N
|
C
|
S
|
E
|
Y
|
G
|
N
|
30 |
R
|
S
|
C
|
P
|
E
|
N
|
E
|
R
|
S
|
L
|
40 |
TM1 | |||||||||
G
|
V
|
R
|
V
|
A
|
M
|
Y
|
S
|
F
|
M
|
50 |
A
|
G
|
S
|
I
|
F
|
I
|
T
|
I
|
F
|
G
|
60 |
N
|
L
|
A
|
M
|
I
|
I
|
S
|
I
|
S
|
Y
|
70 |
ICL1 | TM2 | ||||||||
F
|
K
|
Q
|
L
|
H
|
T
|
P
|
T
|
N
|
F
|
80 |
L
|
I
|
L
|
S
|
M
|
A
|
I
|
T
|
D
|
F
|
90 |
L
|
L
|
G
|
F
|
T
|
I
|
M
|
P
|
Y
|
S
|
100 |
M
|
I
|
R
|
S
|
V
|
E
|
N
|
C
|
W
|
Y
|
110 |
ECL1 | TM3 | ||||||||
F
|
G
|
L
|
T
|
F
|
C
|
K
|
I
|
Y
|
Y
|
120 |
S
|
F
|
D
|
L
|
M
|
L
|
S
|
I
|
T
|
S
|
130 |
I
|
F
|
H
|
L
|
C
|
S
|
V
|
A
|
I
|
D
|
140 |
R
|
F
|
Y
|
A
|
I
|
C
|
Y
|
P
|
L
|
L
|
150 |
ICL2 | TM4 | ||||||||
Y
|
S
|
T
|
K
|
I
|
T
|
I
|
P
|
V
|
I
|
160 |
K
|
R
|
L
|
L
|
L
|
L
|
C
|
W
|
S
|
V
|
170 |
P
|
G
|
A
|
F
|
A
|
F
|
G
|
V
|
V
|
F
|
180 |
ECL2 | |||||||||
S
|
E
|
A
|
Y
|
A
|
D
|
G
|
I
|
E
|
G
|
190 |
Y
|
D
|
I
|
L
|
V
|
A
|
C
|
S
|
S
|
S
|
200 |
TM5 | |||||||||
C
|
P
|
V
|
M
|
F
|
N
|
K
|
L
|
W
|
G
|
210 |
T
|
T
|
L
|
F
|
M
|
A
|
G
|
F
|
F
|
T
|
220 |
P
|
G
|
S
|
M
|
M
|
V
|
G
|
I
|
Y
|
G
|
230 |
K
|
I
|
F
|
A
|
V
|
S
|
R
|
K
|
H
|
A
|
240 |
ICL3 | |||||||||
H
|
A
|
I
|
N
|
N
|
L
|
R
|
E
|
N
|
Q
|
250 |
TM6 | |||||||||
N
|
N
|
Q
|
V
|
K
|
K
|
D
|
K
|
K
|
A
|
260 |
A
|
K
|
T
|
L
|
G
|
I
|
V
|
I
|
G
|
V
|
270 |
F
|
L
|
L
|
C
|
W
|
F
|
P
|
C
|
F
|
F
|
280 |
T
|
I
|
L
|
L
|
D
|
P
|
F
|
L
|
N
|
F
|
290 |
ECL3 | TM7 | ||||||||
S
|
T
|
P
|
V
|
V
|
L
|
F
|
D
|
A
|
L
|
300 |
T
|
W
|
F
|
G
|
Y
|
F
|
N
|
S
|
T
|
C
|
310 |
H8 | |||||||||
N
|
P
|
L
|
I
|
Y
|
G
|
F
|
F
|
Y
|
P
|
320 |
W
|
F
|
R
|
R
|
A
|
L
|
K
|
Y
|
I
|
L
|
330 |
C-term | |||||||||
L
|
G
|
K
|
I
|
F
|
S
|
S
|
C
|
F
|
H
|
340 |
N
|
T
|
I
|
L
|
C
|
M
|
Q
|
K
|
E
|
S
|
350 |
E
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
β-phenylethylamine, tryptamine
STRUCTURE MODELS
STRUCTURES
No structures available