CCR3 (ccr3_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCR3
GENE
CCR3 (CMKBR3)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor type 3, C C CKR3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR 3, CKR3, Eosinophil eotaxin receptor, CD193
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
T
|
S
|
L
|
D
|
T
|
V
|
E
|
T
|
10 |
F
|
G
|
T
|
T
|
S
|
Y
|
Y
|
D
|
D
|
V
|
20 |
TM1 | |||||||||
G
|
L
|
L
|
C
|
E
|
K
|
A
|
D
|
T
|
R
|
30 |
A
|
L
|
M
|
A
|
Q
|
F
|
V
|
P
|
P
|
L
|
40 |
Y
|
S
|
L
|
V
|
F
|
T
|
V
|
G
|
L
|
L
|
50 |
G
|
N
|
V
|
V
|
V
|
V
|
M
|
I
|
L
|
I
|
60 |
ICL1 | TM2 | ||||||||
K
|
Y
|
R
|
R
|
L
|
R
|
I
|
M
|
T
|
N
|
70 |
I
|
Y
|
L
|
L
|
N
|
L
|
A
|
I
|
S
|
D
|
80 |
L
|
L
|
F
|
L
|
V
|
T
|
L
|
P
|
F
|
W
|
90 |
I
|
H
|
Y
|
V
|
R
|
G
|
H
|
N
|
W
|
V
|
100 |
ECL1 | TM3 | ||||||||
F
|
G
|
H
|
G
|
M
|
C
|
K
|
L
|
L
|
S
|
110 |
G
|
F
|
Y
|
H
|
T
|
G
|
L
|
Y
|
S
|
E
|
120 |
I
|
F
|
F
|
I
|
I
|
L
|
L
|
T
|
I
|
D
|
130 |
R
|
Y
|
L
|
A
|
I
|
V
|
H
|
A
|
V
|
F
|
140 |
ICL2 | TM4 | ||||||||
A
|
L
|
R
|
A
|
R
|
T
|
V
|
T
|
F
|
G
|
150 |
V
|
I
|
T
|
S
|
I
|
V
|
T
|
W
|
G
|
L
|
160 |
A
|
V
|
L
|
A
|
A
|
L
|
P
|
E
|
F
|
I
|
170 |
ECL2 | |||||||||
F
|
Y
|
E
|
T
|
E
|
E
|
L
|
F
|
E
|
E
|
180 |
T
|
L
|
C
|
S
|
A
|
L
|
Y
|
P
|
E
|
D
|
190 |
TM5 | |||||||||
T
|
V
|
Y
|
S
|
W
|
R
|
H
|
F
|
H
|
T
|
200 |
L
|
R
|
M
|
T
|
I
|
F
|
C
|
L
|
V
|
L
|
210 |
P
|
L
|
L
|
V
|
M
|
A
|
I
|
C
|
Y
|
T
|
220 |
G
|
I
|
I
|
K
|
T
|
L
|
L
|
R
|
C
|
P
|
230 |
ICL3 | TM6 | ||||||||
S
|
K
|
K
|
K
|
Y
|
K
|
A
|
I
|
R
|
L
|
240 |
I
|
F
|
V
|
I
|
M
|
A
|
V
|
F
|
F
|
I
|
250 |
F
|
W
|
T
|
P
|
Y
|
N
|
V
|
A
|
I
|
L
|
260 |
L
|
S
|
S
|
Y
|
Q
|
S
|
I
|
L
|
F
|
G
|
270 |
ECL3 | TM7 | ||||||||
N
|
D
|
C
|
E
|
R
|
S
|
K
|
H
|
L
|
D
|
280 |
L
|
V
|
M
|
L
|
V
|
T
|
E
|
V
|
I
|
A
|
290 |
Y
|
S
|
H
|
C
|
C
|
M
|
N
|
P
|
V
|
I
|
300 |
H8 | |||||||||
Y
|
A
|
F
|
V
|
G
|
E
|
R
|
F
|
R
|
K
|
310 |
Y
|
L
|
R
|
H
|
F
|
F
|
H
|
R
|
H
|
L
|
320 |
C-term | |||||||||
L
|
M
|
H
|
L
|
G
|
R
|
Y
|
I
|
P
|
F
|
330 |
L
|
P
|
S
|
E
|
K
|
L
|
E
|
R
|
T
|
S
|
340 |
S
|
V
|
S
|
P
|
S
|
T
|
A
|
E
|
P
|
E
|
350 |
L
|
S
|
I
|
V
|
F
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL11, CXCL10, CCL28, CCL15, CCL2, CCL8, CXCL11, CCL5, CCL24, CCL13, CXCL9, CCL7, CCL26
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7X9Y