CCR3 - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7X9Y

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41421-022-00403-4

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

CCL28, CCL8, CXCL11, CCL13, CCL15, CXCL9, CXCL10, CCL7, CCL2, CCL5, CCL11, CCL24, CCL26



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 142 34x54 G.S3 L 602 G.S3.01
Hydrophobic TM5 L 226 5x65 G.H5 L 756 G.H5.20
Van-der-waals TM5 L 226 5x65 G.H5 L 756 G.H5.20
Polar H8 G 337 8x47 G.H5 G 760 G.H5.24
Hydrophobic H8 G 337 8x47 G.H5 G 760 G.H5.24
Van-der-waals H8 G 337 8x47 G.H5 G 760 G.H5.24
Polar H8 E 338 8x48 G.H5 F 762 G.H5.26
Hydrophobic ICL3 P 230 - G.S6 Y 728 G.S6.02
Polar TM2 T 69 2x39 G.H5 C 759 G.H5.23
Hydrophobic TM2 T 69 2x39 G.H5 C 759 G.H5.23
Polar TM3 R 131 3x50 G.H5 C 759 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 C 759 G.H5.23
Van-der-waals TM3 R 131 3x50 G.H5 C 759 G.H5.23
Hydrophobic TM3 A 134 3x53 G.H5 I 752 G.H5.16
Van-der-waals TM3 A 134 3x53 G.H5 I 752 G.H5.16
Hydrophobic TM6 I 241 6x37 G.H5 L 761 G.H5.25
Van-der-waals TM6 I 241 6x37 G.H5 L 761 G.H5.25
Polar ICL2 L 142 34x54 G.hns1 R 38 G.hns1.03
Hydrophobic H8 R 339 8x49 G.H5 K 757 G.H5.21
Polar TM3 A 134 3x53 G.H5 N 755 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 755 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 755 G.H5.19
Hydrophobic ICL2 L 142 34x54 G.H5 I 751 G.H5.15
Hydrophobic TM3 I 135 3x54 G.H5 I 752 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 I 752 G.H5.16
Hydrophobic ICL2 A 138 34x50 G.H5 I 751 G.H5.15
Hydrophobic TM3 R 131 3x50 G.H5 L 761 G.H5.25
Van-der-waals TM3 R 131 3x50 G.H5 L 761 G.H5.25
Hydrophobic TM5 L 226 5x65 G.H5 I 752 G.H5.16
Hydrophobic ICL2 V 139 34x51 G.S3 L 602 G.S3.01
Hydrophobic ICL2 R 143 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 V 139 34x51 G.H5 F 744 G.H5.08
Van-der-waals ICL2 V 139 34x51 G.H5 F 744 G.H5.08
Hydrophobic TM6 A 237 6x33 G.H5 L 756 G.H5.20
Hydrophobic TM3 I 135 3x54 G.H5 L 761 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 L 756 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 756 G.H5.20
Polar ICL3 S 231 - G.h4s6 E 726 G.h4s6.12
Hydrophobic ICL3 S 231 - G.h4s6 E 726 G.h4s6.12
Van-der-waals ICL3 S 231 - G.h4s6 E 726 G.h4s6.12
Ionic H8 R 339 8x49 G.H5 D 758 G.H5.22
Polar H8 R 339 8x49 G.H5 D 758 G.H5.22
Van-der-waals H8 R 339 8x49 G.H5 D 758 G.H5.22
Polar TM6 A 237 6x33 G.H5 L 761 G.H5.25
Hydrophobic TM6 A 237 6x33 G.H5 L 761 G.H5.25
Van-der-waals TM6 A 237 6x33 G.H5 L 761 G.H5.25
Polar H8 R 339 8x49 G.H5 N 754 G.H5.18
Hydrophobic TM6 K 233 6x29 G.H5 F 762 G.H5.26
Van-der-waals TM6 K 233 6x29 G.H5 F 762 G.H5.26
Hydrophobic ICL2 A 138 34x50 G.H5 I 752 G.H5.16
Van-der-waals ICL2 A 138 34x50 G.H5 I 752 G.H5.16
Hydrophobic TM2 T 69 2x39 G.H5 D 758 G.H5.22
Hydrophobic H8 G 337 8x47 G.H5 F 762 G.H5.26
Hydrophobic ICL4 V 336 - G.H5 G 760 G.H5.24
Van-der-waals ICL4 V 336 - G.H5 G 760 G.H5.24
Ionic ICL1 R 66 - G.HN E 34 G.HN.52
Polar ICL1 R 66 - G.HN E 34 G.HN.52
Van-der-waals ICL1 R 66 - G.HN E 34 G.HN.52