CXCR6 (cxcr6_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR6
GENE
CXCR6 (BONZO, STRL33, TYMSTR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-X-C chemokine receptor type 6, CXC-R6, CXCR-6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo, CD186
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
E
|
H
|
D
|
Y
|
H
|
E
|
D
|
Y
|
10 |
G
|
F
|
S
|
S
|
F
|
N
|
D
|
S
|
S
|
Q
|
20 |
TM1 | |||||||||
E
|
E
|
H
|
Q
|
D
|
F
|
L
|
Q
|
F
|
S
|
30 |
K
|
V
|
F
|
L
|
P
|
C
|
M
|
Y
|
L
|
V
|
40 |
V
|
F
|
V
|
C
|
G
|
L
|
V
|
G
|
N
|
S
|
50 |
L
|
V
|
L
|
V
|
I
|
S
|
I
|
F
|
Y
|
H
|
60 |
ICL1 | TM2 | ||||||||
K
|
L
|
Q
|
S
|
L
|
T
|
D
|
V
|
F
|
L
|
70 |
V
|
N
|
L
|
P
|
L
|
A
|
D
|
L
|
V
|
F
|
80 |
V
|
C
|
T
|
L
|
P
|
F
|
W
|
A
|
Y
|
A
|
90 |
ECL1 | TM3 | ||||||||
G
|
I
|
H
|
E
|
W
|
V
|
F
|
G
|
Q
|
V
|
100 |
M
|
C
|
K
|
S
|
L
|
L
|
G
|
I
|
Y
|
T
|
110 |
I
|
N
|
F
|
Y
|
T
|
S
|
M
|
L
|
I
|
L
|
120 |
T
|
C
|
I
|
T
|
V
|
D
|
R
|
F
|
I
|
V
|
130 |
ICL2 | |||||||||
V
|
V
|
K
|
A
|
T
|
K
|
A
|
Y
|
N
|
Q
|
140 |
TM4 | |||||||||
Q
|
A
|
K
|
R
|
M
|
T
|
W
|
G
|
K
|
V
|
150 |
T
|
S
|
L
|
L
|
I
|
W
|
V
|
I
|
S
|
L
|
160 |
L
|
V
|
S
|
L
|
P
|
Q
|
I
|
I
|
Y
|
G
|
170 |
ECL2 | |||||||||
N
|
V
|
F
|
N
|
L
|
D
|
K
|
L
|
I
|
C
|
180 |
TM5 | |||||||||
G
|
Y
|
H
|
D
|
E
|
A
|
I
|
S
|
T
|
V
|
190 |
V
|
L
|
A
|
T
|
Q
|
M
|
T
|
L
|
G
|
F
|
200 |
F
|
L
|
P
|
L
|
L
|
T
|
M
|
I
|
V
|
C
|
210 |
Y
|
S
|
V
|
I
|
I
|
K
|
T
|
L
|
L
|
H
|
220 |
ICL3 | TM6 | ||||||||
A
|
G
|
G
|
F
|
Q
|
K
|
H
|
R
|
S
|
L
|
230 |
K
|
I
|
I
|
F
|
L
|
V
|
M
|
A
|
V
|
F
|
240 |
L
|
L
|
T
|
Q
|
M
|
P
|
F
|
N
|
L
|
M
|
250 |
K
|
F
|
I
|
R
|
S
|
T
|
H
|
W
|
E
|
Y
|
260 |
TM7 | |||||||||
Y
|
A
|
M
|
T
|
S
|
F
|
H
|
Y
|
T
|
I
|
270 |
M
|
V
|
T
|
E
|
A
|
I
|
A
|
Y
|
L
|
R
|
280 |
A
|
C
|
L
|
N
|
P
|
V
|
L
|
Y
|
A
|
F
|
290 |
H8 | |||||||||
V
|
S
|
L
|
K
|
F
|
R
|
K
|
N
|
F
|
W
|
300 |
K
|
L
|
V
|
K
|
D
|
I
|
G
|
C
|
L
|
P
|
310 |
C-term | |||||||||
Y
|
L
|
G
|
V
|
S
|
H
|
Q
|
W
|
K
|
S
|
320 |
S
|
E
|
D
|
N
|
S
|
K
|
T
|
F
|
S
|
A
|
330 |
S
|
H
|
N
|
V
|
E
|
A
|
T
|
S
|
M
|
F
|
340 |
Q
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CXCL16
STRUCTURE MODELS
STRUCTURES
No structures available