A2A receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

April 9, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

adenosine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 Q 207 5x68 G.H5 D 371 G.H5.13
Polar TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Van-der-waals TM5 Q 207 5x68 G.H5 R 375 G.H5.17
Ionic H8 R 296 8x51 G.H5 E 382 G.H5.24
Polar TM3 A 105 3x53 G.H5 H 377 G.H5.19
Hydrophobic TM3 A 105 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 109 - G.H5 Q 374 G.H5.16
Van-der-waals ICL2 P 109 - G.H5 Q 374 G.H5.16
Hydrophobic ICL2 L 110 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 110 - G.H5 I 373 G.H5.15
Hydrophobic TM5 Q 207 5x68 G.H5 L 378 G.H5.20
Hydrophobic ICL3 E 212 - G.H5 R 375 G.H5.17
Van-der-waals ICL3 E 212 - G.H5 R 375 G.H5.17
Aromatic ICL2 Y 112 - G.H5 H 377 G.H5.19
Hydrophobic ICL2 Y 112 - G.H5 H 377 G.H5.19
Polar ICL2 N 113 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 N 113 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 N 113 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 I 106 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 110 - G.H5 C 369 G.H5.11
Hydrophobic TM5 A 204 5x65 G.H5 L 383 G.H5.25
Hydrophobic TM3 I 106 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 I 106 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM5 R 206 5x67 G.H5 Q 374 G.H5.16
Polar TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 I 106 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 I 106 3x54 G.H5 H 377 G.H5.19
Van-der-waals TM3 I 106 3x54 G.H5 H 377 G.H5.19
Hydrophobic ICL2 L 110 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 110 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 L 110 - G.H5 R 370 G.H5.12
Aromatic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 102 3x50 G.H5 Y 381 G.H5.23
Polar ICL2 L 110 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 110 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 110 - G.S1 H 41 G.S1.02
Hydrophobic TM6 A 231 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 231 6x33 G.H5 L 383 G.H5.25
Hydrophobic ICL2 R 111 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 208 5x69 G.H5 L 384 G.H5.26
Van-der-waals TM5 L 208 5x69 G.H5 L 384 G.H5.26
Van-der-waals TM5 Q 207 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM5 Q 207 5x68 G.H5 L 384 G.H5.26
Van-der-waals TM5 Q 207 5x68 G.H5 L 384 G.H5.26
Hydrophobic TM5 A 204 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 A 204 5x65 G.H5 L 378 G.H5.20
Polar ICL3 E 212 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL3 E 212 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 E 212 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals TM5 A 204 5x65 G.H5 L 384 G.H5.26
Hydrophobic TM6 L 235 6x37 G.H5 L 383 G.H5.25
Van-der-waals TM6 L 235 6x37 G.H5 L 383 G.H5.25
Hydrophobic ICL2 L 110 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 110 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 P 109 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 109 - G.H5 I 373 G.H5.15