IP receptor (pi2r_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors IP receptor
GENE
Ptgir
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
M
|
A
|
S
|
D
|
G
|
H
|
P
|
G
|
P
|
10 |
P
|
S
|
V
|
T
|
P
|
G
|
S
|
P
|
L
|
S
|
20 |
A
|
G
|
G
|
R
|
E
|
W
|
Q
|
G
|
M
|
A
|
30 |
G
|
S
|
C
|
W
|
N
|
I
|
T
|
Y
|
V
|
Q
|
40 |
TM1 | |||||||||
D
|
S
|
V
|
G
|
P
|
A
|
T
|
S
|
T
|
L
|
50 |
M
|
F
|
V
|
A
|
G
|
V
|
V
|
G
|
N
|
G
|
60 |
L
|
A
|
L
|
G
|
I
|
L
|
G
|
A
|
R
|
R
|
70 |
ICL1 | TM2 | ||||||||
R
|
S
|
H
|
P
|
S
|
A
|
F
|
A
|
V
|
L
|
80 |
V
|
T
|
G
|
L
|
A
|
V
|
T
|
D
|
L
|
L
|
90 |
G
|
T
|
C
|
F
|
L
|
S
|
P
|
A
|
V
|
F
|
100 |
ECL1 | |||||||||
V
|
A
|
Y
|
A
|
R
|
N
|
S
|
S
|
L
|
L
|
110 |
TM3 | |||||||||
G
|
L
|
A
|
H
|
G
|
G
|
T
|
M
|
L
|
C
|
120 |
D
|
T
|
F
|
A
|
F
|
A
|
M
|
T
|
F
|
F
|
130 |
G
|
L
|
A
|
S
|
T
|
L
|
I
|
L
|
F
|
A
|
140 |
M
|
A
|
V
|
E
|
R
|
C
|
L
|
A
|
L
|
S
|
150 |
ICL2 | |||||||||
H
|
P
|
Y
|
L
|
Y
|
A
|
Q
|
L
|
D
|
G
|
160 |
TM4 | |||||||||
P
|
R
|
C
|
A
|
R
|
F
|
A
|
L
|
P
|
S
|
170 |
I
|
Y
|
A
|
F
|
C
|
C
|
L
|
F
|
C
|
S
|
180 |
ECL2 | |||||||||
L
|
P
|
L
|
L
|
G
|
L
|
G
|
E
|
H
|
Q
|
190 |
Q
|
Y
|
C
|
P
|
G
|
S
|
W
|
C
|
F
|
I
|
200 |
R
|
M
|
R
|
S
|
A
|
Q
|
P
|
G
|
G
|
C
|
210 |
TM5 | |||||||||
A
|
F
|
S
|
L
|
A
|
Y
|
A
|
S
|
L
|
M
|
220 |
A
|
L
|
L
|
V
|
T
|
S
|
I
|
F
|
F
|
C
|
230 |
N
|
G
|
S
|
V
|
T
|
L
|
S
|
L
|
Y
|
H
|
240 |
M
|
Y
|
R
|
Q
|
Q
|
R
|
R
|
H
|
H
|
G
|
250 |
ICL3 | TM6 | ||||||||
S
|
F
|
V
|
P
|
T
|
S
|
R
|
A
|
R
|
E
|
260 |
D
|
E
|
V
|
Y
|
H
|
L
|
I
|
L
|
L
|
A
|
270 |
L
|
M
|
T
|
V
|
I
|
M
|
A
|
V
|
C
|
S
|
280 |
L
|
P
|
L
|
M
|
I
|
R
|
G
|
F
|
T
|
Q
|
290 |
ECL3 | TM7 | ||||||||
A
|
I
|
A
|
P
|
D
|
S
|
R
|
E
|
M
|
G
|
300 |
D
|
L
|
L
|
A
|
F
|
R
|
F
|
N
|
A
|
F
|
310 |
N
|
P
|
I
|
L
|
D
|
P
|
W
|
V
|
F
|
I
|
320 |
H8 | |||||||||
L
|
F
|
R
|
K
|
A
|
V
|
F
|
Q
|
R
|
L
|
330 |
K
|
F
|
W
|
L
|
C
|
C
|
L
|
C
|
A
|
R
|
340 |
C-term | |||||||||
S
|
V
|
H
|
G
|
D
|
L
|
Q
|
A
|
P
|
L
|
350 |
S
|
R
|
P
|
A
|
S
|
G
|
R
|
R
|
D
|
P
|
360 |
P
|
A
|
P
|
T
|
S
|
L
|
Q
|
A
|
K
|
E
|
370 |
G
|
S
|
W
|
V
|
P
|
L
|
S
|
S
|
W
|
G
|
380 |
T
|
G
|
Q
|
V
|
A
|
P
|
L
|
T
|
A
|
V
|
390 |
P
|
L
|
T
|
G
|
G
|
D
|
G
|
C
|
S
|
V
|
400 |
G
|
M
|
P
|
S
|
K
|
S
|
E
|
A
|
I
|
A
|
410 |
A
|
C
|
S
|
L
|
C
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGE1
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available