MC1 receptor (mshr_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor
GENE
MC1R (MSHR)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
V
|
Q
|
G
|
S
|
Q
|
R
|
R
|
L
|
10 |
L
|
G
|
S
|
L
|
N
|
S
|
T
|
P
|
T
|
A
|
20 |
I
|
P
|
Q
|
L
|
G
|
L
|
A
|
A
|
N
|
Q
|
30 |
T
|
G
|
A
|
R
|
C
|
L
|
E
|
V
|
S
|
I
|
40 |
TM1 | |||||||||
S
|
D
|
G
|
L
|
F
|
L
|
S
|
L
|
G
|
L
|
50 |
V
|
S
|
L
|
V
|
E
|
N
|
A
|
L
|
V
|
V
|
60 |
ICL1 | |||||||||
A
|
T
|
I
|
A
|
K
|
N
|
R
|
N
|
L
|
H
|
70 |
TM2 | |||||||||
S
|
P
|
M
|
Y
|
C
|
F
|
I
|
C
|
C
|
L
|
80 |
A
|
L
|
S
|
D
|
L
|
L
|
V
|
S
|
G
|
S
|
90 |
N
|
V
|
L
|
E
|
T
|
A
|
V
|
I
|
L
|
L
|
100 |
ECL1 | |||||||||
L
|
E
|
A
|
G
|
A
|
L
|
V
|
A
|
R
|
A
|
110 |
TM3 | |||||||||
A
|
V
|
L
|
Q
|
Q
|
L
|
D
|
N
|
V
|
I
|
120 |
D
|
V
|
I
|
T
|
C
|
S
|
S
|
M
|
L
|
S
|
130 |
S
|
L
|
C
|
F
|
L
|
G
|
A
|
I
|
A
|
V
|
140 |
D
|
R
|
Y
|
I
|
S
|
I
|
F
|
Y
|
A
|
L
|
150 |
ICL2 | TM4 | ||||||||
R
|
Y
|
H
|
S
|
I
|
V
|
T
|
L
|
P
|
R
|
160 |
A
|
R
|
R
|
A
|
V
|
A
|
A
|
I
|
W
|
V
|
170 |
A
|
S
|
V
|
V
|
F
|
S
|
T
|
L
|
F
|
I
|
180 |
ECL2 | TM5 | ||||||||
A
|
Y
|
Y
|
D
|
H
|
V
|
A
|
V
|
L
|
L
|
190 |
C
|
L
|
V
|
V
|
F
|
F
|
L
|
A
|
M
|
L
|
200 |
V
|
L
|
M
|
A
|
V
|
L
|
Y
|
V
|
H
|
M
|
210 |
L
|
A
|
R
|
A
|
C
|
Q
|
H
|
A
|
Q
|
G
|
220 |
ICL3 | |||||||||
I
|
A
|
R
|
L
|
H
|
K
|
R
|
Q
|
R
|
P
|
230 |
TM6 | |||||||||
V
|
H
|
Q
|
G
|
F
|
G
|
L
|
K
|
G
|
A
|
240 |
V
|
T
|
L
|
T
|
I
|
L
|
L
|
G
|
I
|
F
|
250 |
F
|
L
|
C
|
W
|
G
|
P
|
F
|
F
|
L
|
H
|
260 |
L
|
T
|
L
|
I
|
V
|
L
|
C
|
P
|
E
|
H
|
270 |
ECL3 | |||||||||
P
|
T
|
C
|
G
|
C
|
I
|
F
|
K
|
N
|
F
|
280 |
TM7 | |||||||||
N
|
L
|
F
|
L
|
A
|
L
|
I
|
I
|
C
|
N
|
290 |
A
|
I
|
I
|
D
|
P
|
L
|
I
|
Y
|
A
|
F
|
300 |
H8 | |||||||||
H
|
S
|
Q
|
E
|
L
|
R
|
R
|
T
|
L
|
K
|
310 |
C-term | ||||||
E
|
V
|
L
|
T
|
C
|
S
|
W
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
γ-MSH, β-MSH, α-MSH, ACTH
STRUCTURE MODELS
STRUCTURES
Found 4 structure(s) - view all details on the Structures page