MC1 receptor (mshr_human)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

MC1R (MSHR)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
V
Q
G
S
Q
R
R
L
10
                   
L
G
S
L
N
S
T
P
T
A
20
                   
I
P
Q
L
G
L
A
A
N
Q
30
                   
T
G
A
R
C
L
E
V
S
I
40
TM1              
S
D
G
L
F
L
S
L
G
L
50
                   
V
S
L
V
E
N
A
L
V
V
60
            ICL1
A
T
I
A
K
N
R
N
L
H
70
TM2              
S
P
M
Y
C
F
I
C
C
L
80
                   
A
L
S
D
L
L
V
S
G
S
90
                   
N
V
L
E
T
A
V
I
L
L
100
        ECL1    
L
E
A
G
A
L
V
A
R
A
110
TM3              
A
V
L
Q
Q
L
D
N
V
I
120
                   
D
V
I
T
C
S
S
M
L
S
130
                   
S
L
C
F
L
G
A
I
A
V
140
                   
D
R
Y
I
S
I
F
Y
A
L
150
ICL2     TM4  
R
Y
H
S
I
V
T
L
P
R
160
                   
A
R
R
A
V
A
A
I
W
V
170
                   
A
S
V
V
F
S
T
L
F
I
180
    ECL2 TM5  
A
Y
Y
D
H
V
A
V
L
L
190
                   
C
L
V
V
F
F
L
A
M
L
200
                   
V
L
M
A
V
L
Y
V
H
M
210
                   
L
A
R
A
C
Q
H
A
Q
G
220
            ICL3
I
A
R
L
H
K
R
Q
R
P
230
    TM6          
V
H
Q
G
F
G
L
K
G
A
240
                   
V
T
L
T
I
L
L
G
I
F
250
                   
F
L
C
W
G
P
F
F
L
H
260
                   
L
T
L
I
V
L
C
P
E
H
270
ECL3            
P
T
C
G
C
I
F
K
N
F
280
TM7              
N
L
F
L
A
L
I
I
C
N
290
                   
A
I
I
D
P
L
I
Y
A
F
300
  H8              
H
S
Q
E
L
R
R
T
L
K
310
C-term  
E
V
L
T
C
S
W

LINKS

DIAGRAMS

ICL1 R N L H ICL1ECL1 A L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R Q R P V H ICL3ECL3 P E H P T C G C I F K ECL3N-term M A V Q G S Q R R L L G S L N S T P T A I P Q L G L A A N Q T G A R C L E V S I N-termC-term L K E V L T C S W C-term S D G L F L S L G L V S L V E N A L V V A T I A K N S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y T L P R A R R A V A A I W V A S V V F S T L F I A Y H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K Q G F G L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N E V L S V L G L S L F L G D S 1 C C L A L S D L L V S G S N V L E T A V 2 A G L F C L S S L M S S C T I V D I V N 3 A R R A V A A I W V A S V V F S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L H L T L 6 L P D I I A N C I I L A L F L N F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

γ-MSH, β-MSH, α-MSH, ACTH

STRUCTURE MODELS

STRUCTURES

Found 4 structure(s) - view all details on the Structures page

PDBs: 7F4D, 7F4F, 7F4H, 7F4I