MC1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K3P

RESOLUTION

3.0 Å

REFERENCE

10.1016/J.STR.2025.03.004

PUBLICATION DATE

Aug. 6, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

ACTH (Human), ACTH (Mouse), β-MSH (Human), α-MSH (Human), β-MSH (Mouse), γ-MSH (Human), β-MSH (Rat)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 221 5x72 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 151 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 146 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 146 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 146 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 224 5x75 G.S6 P 361 G.S6.03
Hydrophobic ICL2 L 150 - G.H5 C 379 G.H5.11
Polar TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 - G.S3 V 217 G.S3.01
Polar TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 R 385 G.H5.17
Ionic ICL4 H 301 - G.H5 E 392 G.H5.24
Polar ICL4 H 301 - G.H5 E 392 G.H5.24
Hydrophobic ICL4 H 301 - G.H5 E 392 G.H5.24
Polar TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 L 150 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 150 - G.H5 I 383 G.H5.15
Polar ICL2 H 153 - G.hns1 R 38 G.hns1.02
Aromatic ICL2 H 153 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 153 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 153 - G.hns1 R 38 G.hns1.02
Hydrophobic TM5 H 217 5x68 G.H5 L 394 G.H5.26
Van-der-waals TM5 H 217 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 224 5x75 G.H4 L 346 G.H4.16
Hydrophobic TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 214 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM2 M 73 2x39 G.H5 Y 391 G.H5.23
Polar TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM2 M 73 2x39 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 225 5x76 G.h4s6 T 350 G.h4s6.03
Polar ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 150 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 149 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 A 149 - G.H5 I 383 G.H5.15
Hydrophobic TM5 M 210 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 210 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 R 223 5x74 G.hgh4 D 323 G.hgh4.13
Polar ICL2 H 153 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 H 153 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 H 153 - G.HN Q 35 G.HN.52
Polar TM6 G 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 221 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 R 385 G.H5.17
Hydrophobic ICL2 L 150 - G.H5 R 380 G.H5.12
Hydrophobic TM5 A 214 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 A 214 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 H 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals ICL2 S 154 - G.hns1 A 39 G.hns1.03
Polar ICL2 R 151 - G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 151 - G.s2s3 D 215 G.s2s3.01
Polar TM6 T 242 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 242 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 242 6x36 G.H5 L 393 G.H5.25
Polar TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 150 - G.S3 F 219 G.S3.03
Polar TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Polar ICL2 S 154 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 A 149 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 - G.H5 F 376 G.H5.08