MC1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7F4I

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41422-021-00557-Y

PUBLICATION DATE

Sept. 8, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

58 interactions (Click to see)

LIGANDS

bremelanotide - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

γ-MSH, β-MSH, α-MSH, ACTH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 M 73 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 151 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM7 H 301 7x56 G.H5 Y 391 G.H5.23
Aromatic ICL2 H 153 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 153 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 152 34x53 G.H5 H 387 G.H5.19
Polar TM5 H 217 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 217 5x68 G.H5 R 385 G.H5.17
Polar TM3 S 145 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 145 3x53 G.H5 H 387 G.H5.19
Polar ICL2 L 150 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 150 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 150 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 H 225 5x76 G.h4s6 T 350 G.h4s6.03
Polar TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 213 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 146 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 150 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 150 34x51 G.H5 I 383 G.H5.15
Ionic TM6 K 238 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 238 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 E 392 G.H5.24
Polar ICL2 R 151 34x52 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 151 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 R 213 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM7 H 301 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 H 301 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 217 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 217 5x68 G.H5 Q 384 G.H5.16
Polar TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 217 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 221 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 224 5x75 G.H4 L 346 G.H4.16
Polar TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 221 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 L 150 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 224 5x75 G.S6 P 361 G.S6.03
Polar TM6 K 238 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 L 394 G.H5.26
Hydrophobic ICL2 L 150 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 150 34x51 G.H5 F 376 G.H5.08
Van-der-waals TM7 H 301 7x56 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 A 149 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM5 H 217 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 217 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 242 6x36 G.H5 L 393 G.H5.25
Ionic TM5 R 213 5x64 G.H5 D 381 G.H5.13
Polar TM5 R 213 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 146 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM3 I 146 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 A 214 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 149 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 150 34x51 G.H5 C 379 G.H5.11
Aromatic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 Y 391 G.H5.23
Polar TM6 G 239 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 239 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 239 6x33 G.H5 L 393 G.H5.25
Polar ICL2 H 153 34x54 G.HN Q 35 G.HN.52
Van-der-waals ICL2 H 153 34x54 G.HN Q 35 G.HN.52
Hydrophobic TM5 A 214 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 211 5x62 G.H5 L 393 G.H5.25
Hydrophobic TM5 A 214 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 Y 391 G.H5.23
Polar TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 145 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 210 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 M 210 5x61 G.H5 L 393 G.H5.25