CCR6 (ccr6_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CCR6
GENE
CCR6 (CKRL3, CMKBR6, GPR29, STRL22)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-C chemokine receptor type 6, C-C CKR-6, CC-CKR-6, CCR-6, Chemokine receptor-like 3, CKR-L3, DRY6, G-protein coupled receptor 29, GPR-CY4, GPRCY4, LARC receptor, CD196
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
G
|
E
|
S
|
M
|
N
|
F
|
S
|
D
|
10 |
V
|
F
|
D
|
S
|
S
|
E
|
D
|
Y
|
F
|
V
|
20 |
S
|
V
|
N
|
T
|
S
|
Y
|
Y
|
S
|
V
|
D
|
30 |
S
|
E
|
M
|
L
|
L
|
C
|
S
|
L
|
Q
|
E
|
40 |
TM1 | |||||||||
V
|
R
|
Q
|
F
|
S
|
R
|
L
|
F
|
V
|
P
|
50 |
I
|
A
|
Y
|
S
|
L
|
I
|
C
|
V
|
F
|
G
|
60 |
L
|
L
|
G
|
N
|
I
|
L
|
V
|
V
|
I
|
T
|
70 |
ICL1 | |||||||||
F
|
A
|
F
|
Y
|
K
|
K
|
A
|
R
|
S
|
M
|
80 |
TM2 | |||||||||
T
|
D
|
V
|
Y
|
L
|
L
|
N
|
M
|
A
|
I
|
90 |
A
|
D
|
I
|
L
|
F
|
V
|
L
|
T
|
L
|
P
|
100 |
F
|
W
|
A
|
V
|
S
|
H
|
A
|
T
|
G
|
A
|
110 |
ECL1 | TM3 | ||||||||
W
|
V
|
F
|
S
|
N
|
A
|
T
|
C
|
K
|
L
|
120 |
L
|
K
|
G
|
I
|
Y
|
A
|
I
|
N
|
F
|
N
|
130 |
C
|
G
|
M
|
L
|
L
|
L
|
T
|
C
|
I
|
S
|
140 |
M
|
D
|
R
|
Y
|
I
|
A
|
I
|
V
|
Q
|
A
|
150 |
ICL2 | |||||||||
T
|
K
|
S
|
F
|
R
|
L
|
R
|
S
|
R
|
T
|
160 |
TM4 | |||||||||
L
|
P
|
R
|
S
|
K
|
I
|
I
|
C
|
L
|
V
|
170 |
V
|
W
|
G
|
L
|
S
|
V
|
I
|
I
|
S
|
S
|
180 |
ECL2 | |||||||||
S
|
T
|
F
|
V
|
F
|
N
|
Q
|
K
|
Y
|
N
|
190 |
T
|
Q
|
G
|
S
|
D
|
V
|
C
|
E
|
P
|
K
|
200 |
TM5 | |||||||||
Y
|
Q
|
T
|
V
|
S
|
E
|
P
|
I
|
R
|
W
|
210 |
K
|
L
|
L
|
M
|
L
|
G
|
L
|
E
|
L
|
L
|
220 |
F
|
G
|
F
|
F
|
I
|
P
|
L
|
M
|
F
|
M
|
230 |
I
|
F
|
C
|
Y
|
T
|
F
|
I
|
V
|
K
|
T
|
240 |
ICL3 | TM6 | |||||||||
L
|
V
|
Q
|
A
|
Q
|
N
|
S
|
K
|
R
|
H
|
|
250 |
K
|
A
|
I
|
R
|
V
|
I
|
I
|
A
|
V
|
V
|
260 |
L
|
V
|
F
|
L
|
A
|
C
|
Q
|
I
|
P
|
H
|
270 |
N
|
M
|
V
|
L
|
L
|
V
|
T
|
A
|
A
|
N
|
280 |
ECL3 | TM7 | |||||||||
L
|
G
|
K
|
M
|
N
|
R
|
S
|
C
|
Q
|
S
|
|
290 |
E
|
K
|
L
|
I
|
G
|
Y
|
T
|
K
|
T
|
V
|
300 |
T
|
E
|
V
|
L
|
A
|
F
|
L
|
H
|
C
|
C
|
310 |
L
|
N
|
P
|
V
|
L
|
Y
|
A
|
F
|
I
|
G
|
320 |
H8 | |||||||||
Q
|
K
|
F
|
R
|
N
|
Y
|
F
|
L
|
K
|
I
|
330 |
L
|
K
|
D
|
L
|
W
|
C
|
V
|
R
|
R
|
K
|
340 |
C-term | |||||||||
Y
|
K
|
S
|
S
|
G
|
F
|
S
|
C
|
A
|
G
|
350 |
R
|
Y
|
S
|
E
|
N
|
I
|
S
|
R
|
Q
|
T
|
360 |
S
|
E
|
T
|
A
|
D
|
N
|
D
|
N
|
A
|
S
|
370 |
S
|
F
|
T
|
M
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL20, beta-defensin 4A
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 6WWZ