FFA1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8EIT

RESOLUTION

2.8 Å

REFERENCE

10.1073/PNAS.2219569120

PUBLICATION DATE

May 24, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

15 interactions (Click to see)

LIGANDS

docosahexaenoic acid - Agonist pubchem gtoplig chembl_ligand drug_central drugbank pubchem

PHYSIOLOGICAL LIGANDS

oleic acid, α-linolenic acid, myristic acid, docosahexaenoic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 G 107 3x53 G.H5 N 231 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 231 G.H5.19
Polar TM6 A 222 6x34 G.H5 L 237 G.H5.25
Hydrophobic TM6 A 222 6x34 G.H5 L 237 G.H5.25
Van-der-waals TM6 A 222 6x34 G.H5 L 237 G.H5.25
Hydrophobic TM6 A 226 6x38 G.H5 L 237 G.H5.25
Hydrophobic TM6 V 225 6x37 G.H5 L 237 G.H5.25
Polar TM6 R 218 6x30 G.h4s6 D 198 G.h4s6.10
Polar ICL2 A 116 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 116 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 A 108 3x54 G.H5 L 228 G.H5.16
Hydrophobic ICL2 Q 115 34x54 G.H5 I 227 G.H5.15
Aromatic ICL2 F 117 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 117 34x56 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 F 117 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 214 - G.H5 Q 229 G.H5.17
Van-der-waals ICL3 L 214 - G.H5 Q 229 G.H5.17
Polar ICL2 P 111 34x50 G.H5 N 231 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 N 231 G.H5.19
Polar TM6 R 218 6x30 G.h4s6 G 199 G.h4s6.11
Hydrophobic TM6 R 218 6x30 G.h4s6 G 199 G.h4s6.11
Hydrophobic TM6 R 218 6x30 G.s4h3 V 238 G.s4h3.07
Hydrophobic ICL2 L 112 34x51 G.S1 L 34 G.S1.02
Hydrophobic ICL2 Y 114 34x53 G.H5 N 231 G.H5.19
Van-der-waals ICL2 Y 114 34x53 G.H5 N 231 G.H5.19
Hydrophobic ICL2 L 112 34x51 G.S3 V 71 G.S3.01
Hydrophobic TM3 L 100 3x46 G.H5 Y 235 G.H5.23
Hydrophobic TM5 L 209 5x65 G.H5 L 232 G.H5.20
Ionic TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar TM4 R 119 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 V 225 6x37 G.H5 N 236 G.H5.24
Van-der-waals TM6 V 225 6x37 G.H5 N 236 G.H5.24
Polar TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Hydrophobic TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Van-der-waals TM3 G 103 3x49 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 L 112 34x51 G.H5 K 224 G.H5.12
Hydrophobic TM5 S 212 5x68 G.H5 L 228 G.H5.16
Van-der-waals TM5 S 212 5x68 G.H5 L 228 G.H5.16
Polar C-term Y 278 - G.s4h3 E 234 G.s4h3.03
Hydrophobic TM3 R 104 3x50 G.H5 L 237 G.H5.25
Van-der-waals TM3 R 104 3x50 G.H5 L 237 G.H5.25
Hydrophobic TM3 R 104 3x50 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 P 111 34x50 G.H5 K 224 G.H5.12
Hydrophobic TM3 G 107 3x53 G.H5 L 228 G.H5.16
Van-der-waals TM3 G 107 3x53 G.H5 L 228 G.H5.16
Hydrophobic ICL2 P 111 34x50 G.H5 L 228 G.H5.16
Hydrophobic TM2 S 41 2x39 G.H5 Y 235 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 Y 235 G.H5.23
Hydrophobic TM2 T 39 2x37 G.s4h3 E 234 G.s4h3.03
Van-der-waals TM2 T 39 2x37 G.s4h3 E 234 G.s4h3.03
Hydrophobic ICL2 P 111 34x50 G.H5 I 227 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 227 G.H5.15
Hydrophobic ICL2 L 112 34x51 G.H5 F 220 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 220 G.H5.08
Polar ICL2 R 118 34x57 G.hns1 R 31 G.hns1.02
Polar ICL2 Q 115 34x54 G.hns1 R 31 G.hns1.02
Ionic ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Polar ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Hydrophobic ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Van-der-waals ICL2 R 118 34x57 G.s4h3 E 234 G.s4h3.03
Hydrophobic C-term Y 278 - G.H5 N 236 G.H5.24
Polar ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Van-der-waals ICL2 Y 114 34x53 G.H5 Y 235 G.H5.23
Hydrophobic ICL2 L 112 34x51 G.H5 I 227 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 227 G.H5.15
Polar ICL2 Q 115 34x54 G.H5 N 231 G.H5.19
Van-der-waals ICL2 Q 115 34x54 G.H5 N 231 G.H5.19