LPA4 receptor (lpar4_mouse)

FAMILY

Class A (Rhodopsin) Lipid receptors Lysophospholipid (LPA) receptors LPA4 receptor

GENE

Lpar4 (Gpr23, Lpa4, P2y9)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Lysophosphatidic acid receptor 4, LPA receptor 4, LPA-4, G-protein coupled receptor 23, P2Y purinoceptor 9, P2Y9, Purinergic receptor 9

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
G
D
R
R
F
I
D
F
Q
10
                   
F
Q
D
L
N
S
S
L
R
P
20
                   
R
L
G
N
A
T
A
N
N
T
30
            TM1  
C
I
V
D
D
S
F
K
Y
N
40
                   
L
N
G
A
V
Y
S
V
V
F
50
                   
I
L
G
L
I
T
N
S
A
S
60
                   
L
F
V
F
C
F
R
M
K
M
70
ICL1 TM2      
R
S
E
T
A
I
F
I
T
N
80
                   
L
A
L
S
D
L
L
F
V
C
90
                   
T
L
P
F
K
I
F
Y
N
F
100
  ECL1   TM3  
N
R
H
W
P
F
G
D
T
L
110
                   
C
K
I
S
G
T
A
F
L
T
120
                   
N
I
Y
G
S
M
L
F
L
T
130
                   
C
I
S
V
D
R
F
L
A
I
140
    ICL2        
V
Y
P
F
R
S
R
T
I
R
150
TM4              
T
R
R
N
S
A
I
V
C
A
160
                   
G
V
W
I
L
V
L
S
G
G
170
                   
I
S
A
S
L
F
S
T
T
N
180
ECL2            
V
N
N
A
T
T
T
C
F
E
190
          TM5    
G
F
S
K
R
V
W
K
T
Y
200
                   
L
S
K
I
T
I
F
I
E
V
210
                   
V
G
F
I
I
P
L
I
L
N
220
                   
V
S
C
S
S
V
V
L
R
T
230
        ICL3 TM6
L
R
K
P
A
T
L
S
Q
I
240
                 
G
T
N
K
K
K
V
L
K
M
250
                   
I
T
V
H
M
A
V
F
V
V
260
                   
C
F
V
P
Y
N
S
V
L
F
270
                   
L
Y
A
L
V
R
S
Q
A
I
280
ECL3 TM7      
T
N
C
L
L
E
R
F
A
K
290
                   
I
M
Y
P
I
T
L
C
L
A
300
                   
T
L
N
C
C
F
D
P
F
I
310
        H8        
Y
Y
F
T
L
E
S
F
Q
K
320
                   
S
F
Y
I
N
T
H
I
R
M
330
C-term        
E
S
L
F
K
T
E
T
P
L
340
                   
T
P
K
P
S
L
P
A
I
Q
350
                   
E
E
V
S
D
Q
T
T
N
N
360
                   
G
G
E
L
M
L
E
S
T
F
370

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 M K M R ICL1ECL1 R H W P F ECL1ICL2 P F R S R T I R ICL2ECL2 T T N V N N A T T T C F E G F S K R ECL2ICL3 A T L ICL3ECL3 A I T ECL3N-term M G D R R F I D F Q F Q D L N S S L R P R L G N A T A N N T C I V D D S N-termC-term I R M E S L F K T E T P L T P K P S L P A I Q E E V S D Q T T N N G G E L M L E S T F C-term F K Y N L N G A V Y S V V F I L G L I T N S A S L F V F C F R S E T A I F I T N L A L S D L L F V C T L P F K I F Y N F N G D T L C K I S G T A F L T N I Y G S M L F L T C I S V D R F L A I V Y T R R N S A I V C A G V W I L V L S G G I S A S L F S V W K T Y L S K I T I F I E V V G F I I P L I L N V S C S S V V L R T L R K P S Q I G T N K K K V L K M I T V H M A V F V V C F V P Y N S V L F L Y A L V R S Q N C L L E R F A K I M Y P I T L C L A T L N C C F D P F I Y Y F T L E S F Y I F Q K S N T H
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N T I L G L I F V V S Y V A G N L N Y 1 T N L A L S D L L F V C T L P F K I F Y 2 C T L F L M S G Y I N T L F A T G S I K 3 S A I V C A G V W I L V L S G G I S A S 4 S C S V N L I L P I I F G V V E I F I T I 5 T V H M A V F V V C F V P Y N S V L F L 6 F P D F C C N L T A L C L T I P Y M I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, LYSOPHOSPHATIDIC ACID

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available