ACKR3 (ackr3_rat)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors ACKR3
GENE
Ackr3 (Cmkor1, Cxcr7, Rdc1)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Atypical chemokine receptor 3, C-X-C chemokine receptor type 7, CXC-R7, CXCR-7, Chemokine orphan receptor 1, G-protein coupled receptor RDC1 homolog, RDC-1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
V
|
H
|
L
|
F
|
D
|
Y
|
V
|
E
|
10 |
P
|
G
|
N
|
Y
|
S
|
D
|
I
|
N
|
W
|
P
|
20 |
C
|
N
|
S
|
S
|
D
|
C
|
I
|
V
|
V
|
D
|
30 |
T
|
V
|
Q
|
C
|
P
|
A
|
M
|
P
|
N
|
K
|
40 |
TM1 | |||||||||
N
|
V
|
L
|
L
|
Y
|
T
|
L
|
S
|
F
|
I
|
50 |
Y
|
I
|
F
|
I
|
F
|
V
|
I
|
G
|
M
|
I
|
60 |
A
|
N
|
S
|
V
|
V
|
V
|
W
|
V
|
N
|
I
|
70 |
ICL1 | TM2 | ||||||||
Q
|
A
|
K
|
T
|
T
|
G
|
Y
|
D
|
T
|
H
|
80 |
C
|
Y
|
I
|
L
|
N
|
L
|
A
|
I
|
A
|
D
|
90 |
L
|
W
|
V
|
V
|
I
|
T
|
I
|
P
|
V
|
W
|
100 |
ECL1 | |||||||||
V
|
V
|
S
|
L
|
V
|
Q
|
H
|
N
|
Q
|
W
|
110 |
TM3 | |||||||||
P
|
M
|
G
|
E
|
L
|
T
|
C
|
K
|
I
|
T
|
120 |
H
|
L
|
I
|
F
|
S
|
I
|
N
|
L
|
F
|
G
|
130 |
S
|
I
|
F
|
F
|
L
|
A
|
C
|
M
|
S
|
V
|
140 |
D
|
R
|
Y
|
L
|
S
|
I
|
T
|
Y
|
F
|
T
|
150 |
ICL2 | |||||||||
S
|
T
|
S
|
S
|
Y
|
K
|
K
|
K
|
M
|
V
|
160 |
TM4 | |||||||||
R
|
R
|
V
|
V
|
C
|
V
|
L
|
V
|
W
|
L
|
170 |
L
|
A
|
F
|
F
|
V
|
S
|
L
|
P
|
D
|
T
|
180 |
ECL2 | |||||||||
Y
|
Y
|
L
|
K
|
T
|
V
|
T
|
S
|
A
|
S
|
190 |
N
|
N
|
E
|
T
|
Y
|
C
|
R
|
S
|
F
|
Y
|
200 |
TM5 | |||||||||
P
|
E
|
H
|
S
|
I
|
K
|
E
|
W
|
L
|
I
|
210 |
G
|
M
|
E
|
L
|
V
|
S
|
V
|
I
|
L
|
G
|
220 |
F
|
A
|
V
|
P
|
F
|
T
|
I
|
I
|
A
|
I
|
230 |
F
|
Y
|
F
|
L
|
L
|
A
|
R
|
A
|
M
|
S
|
240 |
ICL3 | TM6 | ||||||||
A
|
S
|
G
|
D
|
Q
|
E
|
K
|
H
|
S
|
S
|
250 |
R
|
K
|
I
|
I
|
F
|
S
|
Y
|
V
|
V
|
V
|
260 |
F
|
L
|
V
|
C
|
W
|
L
|
P
|
Y
|
H
|
F
|
270 |
V
|
V
|
L
|
L
|
D
|
I
|
F
|
S
|
I
|
L
|
280 |
ECL3 | TM7 | ||||||||
H
|
Y
|
I
|
P
|
F
|
T
|
C
|
Q
|
L
|
E
|
290 |
N
|
V
|
L
|
F
|
T
|
A
|
L
|
H
|
V
|
T
|
300 |
Q
|
C
|
L
|
S
|
L
|
V
|
H
|
C
|
C
|
V
|
310 |
H8 | |||||||||
N
|
P
|
V
|
L
|
Y
|
S
|
F
|
I
|
N
|
R
|
320 |
N
|
Y
|
R
|
Y
|
E
|
L
|
M
|
K
|
A
|
F
|
330 |
C-term | |||||||||
I
|
F
|
K
|
Y
|
S
|
A
|
K
|
T
|
G
|
L
|
340 |
T
|
K
|
L
|
I
|
D
|
A
|
S
|
R
|
V
|
S
|
350 |
E
|
T
|
E
|
Y
|
S
|
A
|
L
|
E
|
Q
|
N
|
360 |
T
|
K
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
adrenomedullin
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available