EP4 receptor (pe2r4_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP4 receptor
GENE
PTGER4 (PTGER2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
S
|
T
|
P
|
G
|
V
|
N
|
S
|
S
|
A
|
10 |
TM1 | |||||||||
S
|
L
|
S
|
P
|
D
|
R
|
L
|
N
|
S
|
P
|
20 |
V
|
T
|
I
|
P
|
A
|
V
|
M
|
F
|
I
|
F
|
30 |
G
|
V
|
V
|
G
|
N
|
L
|
V
|
A
|
I
|
V
|
40 |
ICL1 | |||||||||
V
|
L
|
C
|
K
|
S
|
R
|
K
|
E
|
Q
|
K
|
50 |
TM2 | |||||||||
E
|
T
|
T
|
F
|
Y
|
T
|
L
|
V
|
C
|
G
|
60 |
L
|
A
|
V
|
T
|
D
|
L
|
L
|
G
|
T
|
L
|
70 |
L
|
V
|
S
|
P
|
V
|
T
|
I
|
A
|
T
|
Y
|
80 |
ECL1 | TM3 | ||||||||
M
|
K
|
G
|
Q
|
W
|
P
|
G
|
G
|
Q
|
P
|
90 |
L
|
C
|
E
|
Y
|
S
|
T
|
F
|
I
|
L
|
L
|
100 |
F
|
F
|
S
|
L
|
S
|
G
|
L
|
S
|
I
|
I
|
110 |
C
|
A
|
M
|
S
|
V
|
E
|
R
|
Y
|
L
|
A
|
120 |
ICL2 | |||||||||
I
|
N
|
H
|
A
|
Y
|
F
|
Y
|
S
|
H
|
Y
|
130 |
TM4 | |||||||||
V
|
D
|
K
|
R
|
L
|
A
|
G
|
L
|
T
|
L
|
140 |
F
|
A
|
V
|
Y
|
A
|
S
|
N
|
V
|
L
|
F
|
150 |
C
|
A
|
L
|
P
|
N
|
M
|
G
|
L
|
G
|
S
|
160 |
ECL2 | |||||||||
S
|
R
|
L
|
Q
|
Y
|
P
|
D
|
T
|
W
|
C
|
170 |
TM5 | |||||||||
F
|
I
|
D
|
W
|
T
|
T
|
N
|
V
|
T
|
A
|
180 |
H
|
A
|
A
|
Y
|
S
|
Y
|
M
|
Y
|
A
|
G
|
190 |
F
|
S
|
S
|
F
|
L
|
I
|
L
|
A
|
T
|
V
|
200 |
L
|
C
|
N
|
V
|
L
|
V
|
C
|
G
|
A
|
L
|
210 |
L
|
R
|
M
|
H
|
R
|
Q
|
F
|
M
|
R
|
R
|
220 |
ICL3 | |||||||||
T
|
S
|
L
|
G
|
T
|
E
|
Q
|
H
|
H
|
A
|
230 |
A
|
A
|
A
|
A
|
S
|
V
|
A
|
S
|
R
|
G
|
240 |
H
|
P
|
A
|
A
|
S
|
P
|
A
|
L
|
P
|
R
|
250 |
L
|
S
|
D
|
F
|
R
|
R
|
R
|
R
|
S
|
F
|
260 |
TM6 | |||||||||
R
|
R
|
I
|
A
|
G
|
A
|
E
|
I
|
Q
|
M
|
270 |
V
|
I
|
L
|
L
|
I
|
A
|
T
|
S
|
L
|
V
|
280 |
V
|
L
|
I
|
C
|
S
|
I
|
P
|
L
|
V
|
V
|
290 |
R
|
V
|
F
|
V
|
N
|
Q
|
L
|
Y
|
Q
|
P
|
300 |
ECL3 | |||||||||
S
|
L
|
E
|
R
|
E
|
V
|
S
|
K
|
N
|
P
|
310 |
TM7 | |||||||||
D
|
L
|
Q
|
A
|
I
|
R
|
I
|
A
|
S
|
V
|
320 |
N
|
P
|
I
|
L
|
D
|
P
|
W
|
I
|
Y
|
I
|
330 |
H8 | |||||||||
L
|
L
|
R
|
K
|
T
|
V
|
L
|
S
|
K
|
A
|
340 |
I
|
E
|
K
|
I
|
K
|
C
|
L
|
F
|
C
|
R
|
350 |
C-term | |||||||||
I
|
G
|
G
|
S
|
R
|
R
|
E
|
R
|
S
|
G
|
360 |
Q
|
H
|
C
|
S
|
D
|
S
|
Q
|
R
|
T
|
S
|
370 |
S
|
A
|
M
|
S
|
G
|
H
|
S
|
R
|
S
|
F
|
380 |
I
|
S
|
R
|
E
|
L
|
K
|
E
|
I
|
S
|
S
|
390 |
T
|
S
|
Q
|
T
|
L
|
L
|
P
|
D
|
L
|
S
|
400 |
L
|
P
|
D
|
L
|
S
|
E
|
N
|
G
|
L
|
G
|
410 |
G
|
R
|
N
|
L
|
L
|
P
|
G
|
V
|
P
|
G
|
420 |
M
|
G
|
L
|
A
|
Q
|
E
|
D
|
T
|
T
|
S
|
430 |
L
|
R
|
T
|
L
|
R
|
I
|
S
|
E
|
T
|
S
|
440 |
D
|
S
|
S
|
Q
|
G
|
Q
|
D
|
S
|
E
|
S
|
450 |
V
|
L
|
L
|
V
|
D
|
E
|
A
|
G
|
G
|
S
|
460 |
G
|
R
|
A
|
G
|
P
|
A
|
P
|
K
|
G
|
S
|
470 |
S
|
L
|
Q
|
V
|
T
|
F
|
P
|
S
|
E
|
T
|
480 |
L
|
N
|
L
|
S
|
E
|
K
|
C
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGF2α, PGI2, PGD2, thromboxane A2, PGE1, PGE2