CXCR5 (cxcr5_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR5
GENE
CXCR5 (BLR1, MDR15)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15, CD185
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
Y
|
P
|
L
|
T
|
L
|
E
|
M
|
D
|
10 |
L
|
E
|
N
|
L
|
E
|
D
|
L
|
F
|
W
|
E
|
20 |
L
|
D
|
R
|
L
|
D
|
N
|
Y
|
N
|
D
|
T
|
30 |
S
|
L
|
V
|
E
|
N
|
H
|
L
|
C
|
P
|
A
|
40 |
TM1 | |||||||||
T
|
E
|
G
|
P
|
L
|
M
|
A
|
S
|
F
|
K
|
50 |
A
|
V
|
F
|
V
|
P
|
V
|
A
|
Y
|
S
|
L
|
60 |
I
|
F
|
L
|
L
|
G
|
V
|
I
|
G
|
N
|
V
|
70 |
L
|
V
|
L
|
V
|
I
|
L
|
E
|
R
|
H
|
R
|
80 |
ICL1 | TM2 | ||||||||
Q
|
T
|
R
|
S
|
S
|
T
|
E
|
T
|
F
|
L
|
90 |
F
|
H
|
L
|
A
|
V
|
A
|
D
|
L
|
L
|
L
|
100 |
V
|
F
|
I
|
L
|
P
|
F
|
A
|
V
|
A
|
E
|
110 |
ECL1 | TM3 | ||||||||
G
|
S
|
V
|
G
|
W
|
V
|
L
|
G
|
T
|
F
|
120 |
L
|
C
|
K
|
T
|
V
|
I
|
A
|
L
|
H
|
K
|
130 |
V
|
N
|
F
|
Y
|
C
|
S
|
S
|
L
|
L
|
L
|
140 |
A
|
C
|
I
|
A
|
V
|
D
|
R
|
Y
|
L
|
A
|
150 |
ICL2 | |||||||||
I
|
V
|
H
|
A
|
V
|
H
|
A
|
Y
|
R
|
H
|
160 |
TM4 | |||||||||
R
|
R
|
L
|
L
|
S
|
I
|
H
|
I
|
T
|
C
|
170 |
G
|
T
|
I
|
W
|
L
|
V
|
G
|
F
|
L
|
L
|
180 |
A
|
L
|
P
|
E
|
I
|
L
|
F
|
A
|
K
|
V
|
190 |
ECL2 | |||||||||
S
|
Q
|
G
|
H
|
H
|
N
|
N
|
S
|
L
|
P
|
200 |
R
|
C
|
T
|
F
|
S
|
Q
|
E
|
N
|
Q
|
A
|
210 |
TM5 | |||||||||
E
|
T
|
H
|
A
|
W
|
F
|
T
|
S
|
R
|
F
|
220 |
L
|
Y
|
H
|
V
|
A
|
G
|
F
|
L
|
L
|
P
|
230 |
M
|
L
|
V
|
M
|
G
|
W
|
C
|
Y
|
V
|
G
|
240 |
V
|
V
|
H
|
R
|
L
|
R
|
Q
|
A
|
Q
|
R
|
250 |
ICL3 | TM6 | ||||||||
R
|
P
|
Q
|
R
|
Q
|
K
|
A
|
V
|
R
|
V
|
260 |
A
|
I
|
L
|
V
|
T
|
S
|
I
|
F
|
F
|
L
|
270 |
C
|
W
|
S
|
P
|
Y
|
H
|
I
|
V
|
I
|
F
|
280 |
L
|
D
|
T
|
L
|
A
|
R
|
L
|
K
|
A
|
V
|
290 |
ECL3 | TM7 | ||||||||
D
|
N
|
T
|
C
|
K
|
L
|
N
|
G
|
S
|
L
|
300 |
P
|
V
|
A
|
I
|
T
|
M
|
C
|
E
|
F
|
L
|
310 |
G
|
L
|
A
|
H
|
C
|
C
|
L
|
N
|
P
|
M
|
320 |
H8 | |||||||||
L
|
Y
|
T
|
F
|
A
|
G
|
V
|
K
|
F
|
R
|
330 |
S
|
D
|
L
|
S
|
R
|
L
|
L
|
T
|
K
|
L
|
340 |
C-term | |||||||||
G
|
C
|
T
|
G
|
P
|
A
|
S
|
L
|
C
|
Q
|
350 |
L
|
F
|
P
|
S
|
W
|
R
|
R
|
S
|
S
|
L
|
360 |
S
|
E
|
S
|
E
|
N
|
A
|
T
|
S
|
L
|
T
|
370 |
T
|
F
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CXCL13
STRUCTURE MODELS
STRUCTURES
No structures available