GPR174 (gp174_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR174
GENE
GPR174 (FKSG79, GPCR17)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Probable G-protein coupled receptor 174
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
P
|
A
|
N
|
Y
|
T
|
C
|
T
|
R
|
P
|
10 |
TM1 | |||||||||
D
|
G
|
D
|
N
|
T
|
D
|
F
|
R
|
Y
|
F
|
20 |
I
|
Y
|
A
|
V
|
T
|
Y
|
T
|
V
|
I
|
L
|
30 |
V
|
P
|
G
|
L
|
I
|
G
|
N
|
I
|
L
|
A
|
40 |
L
|
W
|
V
|
F
|
Y
|
G
|
Y
|
M
|
K
|
E
|
50 |
ICL1 | TM2 | ||||||||
T
|
K
|
R
|
A
|
V
|
I
|
F
|
M
|
I
|
N
|
60 |
L
|
A
|
I
|
A
|
D
|
L
|
L
|
Q
|
V
|
L
|
70 |
S
|
L
|
P
|
L
|
R
|
I
|
F
|
Y
|
Y
|
L
|
80 |
ECL1 | TM3 | ||||||||
N
|
H
|
D
|
W
|
P
|
F
|
G
|
P
|
G
|
L
|
90 |
C
|
M
|
F
|
C
|
F
|
Y
|
L
|
K
|
Y
|
V
|
100 |
N
|
M
|
Y
|
A
|
S
|
I
|
Y
|
F
|
L
|
V
|
110 |
C
|
I
|
S
|
V
|
R
|
R
|
F
|
W
|
F
|
L
|
120 |
ICL2 | |||||||||
M
|
Y
|
P
|
F
|
R
|
F
|
H
|
D
|
C
|
K
|
130 |
TM4 | |||||||||
Q
|
K
|
Y
|
D
|
L
|
Y
|
I
|
S
|
I
|
A
|
140 |
G
|
W
|
L
|
I
|
I
|
C
|
L
|
A
|
C
|
V
|
150 |
ECL2 | |||||||||
L
|
F
|
P
|
L
|
L
|
R
|
T
|
S
|
D
|
D
|
160 |
T
|
S
|
G
|
N
|
R
|
T
|
K
|
C
|
F
|
V
|
170 |
TM5 | |||||||||
D
|
L
|
P
|
T
|
R
|
N
|
V
|
N
|
L
|
A
|
180 |
Q
|
S
|
V
|
V
|
M
|
M
|
T
|
I
|
G
|
E
|
190 |
L
|
I
|
G
|
F
|
V
|
T
|
P
|
L
|
L
|
I
|
200 |
V
|
L
|
Y
|
C
|
T
|
W
|
K
|
T
|
V
|
L
|
210 |
ICL3 | |||||||||
S
|
L
|
Q
|
D
|
K
|
Y
|
P
|
M
|
A
|
Q
|
220 |
TM6 | |||||||||
D
|
L
|
G
|
E
|
K
|
Q
|
K
|
A
|
L
|
K
|
230 |
M
|
I
|
L
|
T
|
C
|
A
|
G
|
V
|
F
|
L
|
240 |
I
|
C
|
F
|
A
|
P
|
Y
|
H
|
F
|
S
|
F
|
250 |
P
|
L
|
D
|
F
|
L
|
V
|
K
|
S
|
N
|
E
|
260 |
ECL3 | TM7 | ||||||||
I
|
K
|
S
|
C
|
L
|
A
|
R
|
R
|
V
|
I
|
270 |
L
|
I
|
F
|
H
|
S
|
V
|
A
|
L
|
C
|
L
|
280 |
A
|
S
|
L
|
N
|
S
|
C
|
L
|
D
|
P
|
V
|
290 |
H8 | |||||||||
I
|
Y
|
Y
|
F
|
S
|
T
|
N
|
E
|
F
|
R
|
300 |
R
|
R
|
L
|
S
|
R
|
Q
|
D
|
L
|
H
|
D
|
310 |
C-term | |||||||||
S
|
I
|
Q
|
L
|
H
|
A
|
K
|
S
|
F
|
V
|
320 |
S
|
N
|
H
|
T
|
A
|
S
|
T
|
M
|
T
|
P
|
330 |
E
|
L
|
C
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
lysophosphatidylserine
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page