GPR174 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8KH5

RESOLUTION

2.8 Å

REFERENCE

10.1038/S41467-023-41654-3

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

68 interactions (Click to see)

LIGANDS

Lysophosphotidylserine - Agonist pubchem

ENDOGENOUS LIGANDS

lysophosphatidylserine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 F 57 2x42 G.H5 L 394 G.H5.26
Hydrophobic TM2 F 57 2x42 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 124 34x51 G.H5 C 379 G.H5.11
Polar ICL2 H 127 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 127 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 H 127 34x54 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 H 127 34x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 212 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 123 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 123 34x50 G.H5 Q 384 G.H5.16
Polar TM2 I 56 2x41 G.H5 L 394 G.H5.26
Ionic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar TM6 K 225 6x30 G.H5 D 381 G.H5.13
Hydrophobic TM6 K 225 6x30 G.H5 D 381 G.H5.13
Van-der-waals TM6 K 225 6x30 G.H5 D 381 G.H5.13
Polar ICL3 L 222 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 L 222 - G.h4s6 Y 358 G.h4s6.20
Aromatic ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 126 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL3 L 222 - G.h4s6 G 355 G.h4s6.11
Polar TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 120 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 M 218 - G.H5 N 377 G.H5.09
Ionic ICL3 D 221 - G.H5 R 385 G.H5.17
Polar ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 D 221 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 D 221 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 123 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM2 V 55 2x40 G.H5 L 394 G.H5.26
Van-der-waals TM2 V 55 2x40 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 218 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 M 218 - G.H5 D 381 G.H5.13
Aromatic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 124 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 P 123 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 123 34x50 G.H5 I 383 G.H5.15
Ionic TM6 E 224 6x29 G.H5 R 389 G.H5.21
Ionic TM6 E 224 6x29 G.H5 R 385 G.H5.17
Polar TM6 E 224 6x29 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 224 6x29 G.H5 R 385 G.H5.17
Hydrophobic ICL3 A 219 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 A 219 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 Q 220 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM7 Y 293 7x54 G.H5 L 393 G.H5.25
Hydrophobic TM1 Y 47 1x60 G.H5 L 393 G.H5.25
Hydrophobic TM1 F 44 1x57 G.H5 L 393 G.H5.25
Van-der-waals TM1 F 44 1x57 G.H5 L 393 G.H5.25
Polar ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 R 53 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 R 53 - G.H5 Q 390 G.H5.22
Hydrophobic TM2 M 58 2x43 G.H5 L 394 G.H5.26
Van-der-waals TM2 M 58 2x43 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 120 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 D 221 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic H8 E 298 8x49 G.H5 L 393 G.H5.25
Van-der-waals H8 E 298 8x49 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 225 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Q 131 - G.H5 Y 391 G.H5.23
Hydrophobic ICL3 M 218 - G.S6 Y 360 G.S6.02
Hydrophobic TM3 F 119 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 F 119 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM2 M 58 2x43 G.H5 L 393 G.H5.25
Van-der-waals TM2 M 58 2x43 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 124 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 124 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 R 115 3x49 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 115 3x49 G.H5 L 394 G.H5.26
Polar H8 E 298 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 298 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL3 L 222 - G.h4s6 D 354 G.h4s6.10
Hydrophobic TM3 I 112 3x46 G.H5 L 394 G.H5.26
Polar ICL3 A 219 - G.H5 R 385 G.H5.17
Polar TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 E 224 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM3 F 119 3x53 G.H5 L 394 G.H5.26
Van-der-waals TM3 F 119 3x53 G.H5 L 394 G.H5.26
Polar TM3 M 121 3x55 G.H5 R 380 G.H5.12
Polar H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 T 296 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 296 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 F 299 8x50 G.H5 L 393 G.H5.25
Van-der-waals H8 F 299 8x50 G.H5 L 393 G.H5.25
Hydrophobic H8 T 296 8x47 G.H5 L 393 G.H5.25
Van-der-waals H8 T 296 8x47 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 116 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 R 116 3x50 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 225 6x30 G.H5 R 385 G.H5.17
Hydrophobic ICL2 F 124 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 124 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 124 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 124 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 124 34x51 G.S3 V 217 G.S3.01
Aromatic ICL2 F 126 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 F 126 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 F 126 34x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 120 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 120 3x54 G.H5 L 388 G.H5.20
Polar ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 123 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL3 A 219 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 A 219 - G.h4s6 Y 358 G.h4s6.20
Polar TM1 Y 47 1x60 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 D 128 34x55 G.H5 Y 391 G.H5.23
Polar TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Van-der-waals TM6 K 225 6x30 G.H5 Q 384 G.H5.16
Polar H8 N 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 N 297 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 N 297 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 228 6x33 G.H5 L 388 G.H5.20
Van-der-waals TM6 A 228 6x33 G.H5 L 388 G.H5.20
Aromatic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 119 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 V 55 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 V 55 2x40 G.H5 L 393 G.H5.25