Structure information

GPR174

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8KH5

SPECIES

Homo sapiens

RESOLUTION

2.830

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-023-41654-3

PUBLICATION DATE

Oct. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysophosphotidylserine Y22 1.35x35 TM1 hydrophobic
Lysophosphotidylserine Y26 1.39x39 TM1 polar (hydrogen bond)
Lysophosphotidylserine Y26 1.39x39 TM1 Van der Waals
Lysophosphotidylserine R75 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Lysophosphotidylserine Y79 2.64x64 TM2 Van der Waals
Lysophosphotidylserine Y79 2.64x64 TM2 polar (hydrogen bond)
Lysophosphotidylserine F95 3.29x29 TM3 Van der Waals
Lysophosphotidylserine F95 3.29x29 TM3 hydrophobic
Lysophosphotidylserine K98 3.32x32 TM3 Van der Waals
Lysophosphotidylserine Y99 3.33x33 TM3 polar (hydrogen bond)
Lysophosphotidylserine Y99 3.33x33 TM3 polar (hydrogen bond)
Lysophosphotidylserine Y103 3.37x37 TM3 hydrophobic
Lysophosphotidylserine Y103 3.37x37 TM3 Van der Waals
Lysophosphotidylserine I145 4.53x53 TM4 Van der Waals
Lysophosphotidylserine I145 4.53x53 TM4 hydrophobic
Lysophosphotidylserine A148 4.56x56 TM4 hydrophobic
Lysophosphotidylserine A148 4.56x56 TM4 Van der Waals
Lysophosphotidylserine L151 4.59x59 TM4 Van der Waals
Lysophosphotidylserine L151 4.59x59 TM4 hydrophobic
Lysophosphotidylserine F152 4.60x60 TM4 Van der Waals
Lysophosphotidylserine F152 4.60x60 TM4 hydrophobic
Lysophosphotidylserine L155 4.63x63 TM4 Van der Waals
Lysophosphotidylserine L155 4.63x63 TM4 hydrophobic
Lysophosphotidylserine R156 ECL2 polar (charge-assisted hydrogen bond)
Lysophosphotidylserine F169 45.51x51 ECL2 Van der Waals
Lysophosphotidylserine V170 45.52x52 ECL2 Van der Waals
Lysophosphotidylserine M185 5.38x39 TM5 Van der Waals
Lysophosphotidylserine G189 5.42x43 TM5 Van der Waals
Lysophosphotidylserine F250 6.55x55 TM6 hydrophobic
Lysophosphotidylserine F250 6.55x55 TM6 Van der Waals
Lysophosphotidylserine D253 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Lysophosphotidylserine F254 6.59x59 TM6 Van der Waals
Lysophosphotidylserine K257 6.62x62 TM6 polar (charge-assisted hydrogen bond)
Lysophosphotidylserine H274 7.35x34 TM7 polar (hydrogen bond)
Lysophosphotidylserine H274 7.35x34 TM7 Van der Waals
Lysophosphotidylserine L278 7.39x38 TM7 hydrophobic
Lysophosphotidylserine L278 7.39x38 TM7 Van der Waals

Ligands

Lysophosphotidylserine

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Residue Diagrams

I N G I L G P V L I V T Y T V A Y I F Y 1 I N L A I A D L L Q V L S L P L R I F Y 2 C V L F Y I S A Y M N V Y K L Y F C F M 3 D L Y I S I A G W L I I C L A C V L F P 4 T C Y L V I L L P T V F G I L E G I T M M 5 L T C A G V F L I C F A P Y H F S F P L 6 V P D L C S N L S A L C L A V S H F I 7
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ICL1 K R A ICL1ECL1 D W P F ECL1ICL2 P F R F H D C ICL2ECL2 T S D D T S G N R T K C F V D L P T R N V ECL2ICL3 Q D K Y P M A Q D L ICL3ECL3 E I K ECL3N-term M P A N Y T C T R P D G D N T D N-termC-term H D S I Q L H A K S F V S N H T A S T M T P E L C C-term F R Y F I Y A V T Y T V I L V P G L I G N I L A L W V F Y G Y M K E T V I F M I N L A I A D L L Q V L S L P L R I F Y Y L N H G P G L C M F C F Y L K Y V N M Y A S I Y F L V C I S V R R F W F L M Y K Q K Y D L Y I S I A G W L I I C L A C V L F P L L R N L A Q S V V M M T I G E L I G F V T P L L I V L Y C T W K T V L S L G E K Q K A L K M I L T C A G V F L I C F A P Y H F S F P L D F L V K S N S C L A R R V I L I F H S V A L C L A S L N S C L D P V I Y Y F S T N E L S R F R R R Q D L
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR174
TM1
1x35 1.35x35 Y22
1x39 1.39x39 Y26
TM2
2x60 2.60x60 R75
2x64 2.64x64 Y79
TM3
3x29 3.29x29 F95
3x32 3.32x32 K98
3x33 3.33x33 Y99
3x37 3.37x37 Y103
TM4
4x53 4.53x53 I145
4x56 4.56x56 A148
4x59 4.59x59 L151
4x60 4.60x60 F152
4x63 4.63x63 L155
ECL2
45x51 45.51x51 F169
45x52 45.52x52 V170
TM5
5x39 5.38x39 M185
5x43 5.42x43 G189
TM6
6x55 6.55x55 F250
6x58 6.58x58 D253
6x59 6.59x59 F254
6x62 6.62x62 K257
TM7
7x34 7.35x34 H274
7x38 7.39x38 L278