GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
L-serine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem ,
LYSOPHOSPHATIDIC ACID - Agonist chembl_ligand pubchem
PHYSIOLOGICAL LIGANDS
lysophosphatidylserine
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 112 | 3x46 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | I | 112 | 3x46 | G.H5 | L | 394 | G.H5.26 |
Aromatic | ICL2 | F | 124 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 124 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 124 | - | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | F | 124 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 124 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 124 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | TM5 | L | 212 | 5x65 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | P | 123 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | H | 127 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | H | 127 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | H | 127 | - | G.hns1 | R | 38 | G.hns1.02 |
Ionic | TM6 | K | 225 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | K | 225 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | K | 225 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | K | 225 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | A | 228 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Ionic | ICL3 | D | 221 | - | G.H5 | R | 385 | G.H5.17 |
Polar | ICL3 | D | 221 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | D | 221 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | D | 221 | - | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | P | 123 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 123 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | P | 123 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 123 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | F | 126 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | F | 126 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | H | 127 | - | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM6 | E | 224 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | E | 224 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | E | 224 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | K | 225 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM2 | V | 55 | 2x40 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | V | 55 | 2x40 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | F | 124 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL2 | F | 124 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL3 | M | 218 | - | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | ICL3 | M | 218 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL1 | R | 53 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL1 | R | 53 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | D | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | D | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | D | 221 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL1 | A | 54 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL1 | A | 54 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | L | 222 | - | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | TM2 | M | 58 | 2x43 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | M | 58 | 2x43 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | Q | 220 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | Q | 220 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | Q | 220 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM5 | L | 212 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | L | 212 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | M | 121 | 3x55 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | Q | 220 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | H8 | N | 297 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | N | 297 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 297 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | L | 222 | - | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | ICL1 | R | 53 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL1 | R | 53 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL1 | R | 53 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | TM1 | Y | 47 | 1x60 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM6 | E | 224 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Polar | TM2 | I | 56 | 2x41 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM1 | Y | 47 | 1x60 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | D | 128 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | D | 128 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | TM5 | S | 211 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | S | 211 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Aromatic | ICL2 | F | 126 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 126 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | F | 126 | - | G.H5 | Y | 391 | G.H5.23 |
Ionic | ICL2 | D | 128 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | D | 128 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | D | 128 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | D | 128 | - | G.hns1 | R | 38 | G.hns1.02 |
Ionic | TM6 | E | 224 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | E | 224 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | E | 224 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | R | 116 | 3x50 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | R | 116 | 3x50 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM6 | E | 224 | 6x29 | G.H5 | R | 389 | G.H5.21 |
Polar | TM6 | E | 224 | 6x29 | G.H5 | R | 389 | G.H5.21 |
Polar | H8 | E | 298 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | C | 129 | - | G.HN | K | 34 | G.HN.51 |
Polar | TM3 | F | 119 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | F | 119 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | F | 119 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | M | 58 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | C | 129 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | C | 129 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | C | 129 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM6 | K | 225 | 6x30 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | K | 225 | 6x30 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | C | 129 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM1 | F | 44 | 1x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | F | 57 | 2x42 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | M | 218 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | ICL3 | M | 218 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | H8 | T | 296 | 8x47 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | F | 119 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | F | 119 | 3x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | F | 124 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 124 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | F | 119 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 124 | - | G.S3 | F | 219 | G.S3.03 |
Polar | ICL2 | Q | 131 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | Q | 131 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | F | 299 | 8x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | H8 | E | 298 | 8x49 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 123 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | H8 | T | 296 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | T | 296 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Ionic | ICL3 | D | 214 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM3 | R | 115 | 3x49 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | R | 115 | 3x49 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | F | 124 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | L | 120 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | L | 120 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | L | 120 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 120 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM2 | V | 55 | 2x40 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | V | 55 | 2x40 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | V | 55 | 2x40 | G.H5 | L | 394 | G.H5.26 |