GPR17 (gpr17_mouse)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans GPR17

GENE

Gpr17

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Uracil nucleotide/cysteinyl leukotriene receptor, UDP/CysLT receptor, G-protein coupled receptor 17

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
G
L
E
A
A
L
P
S
10
                   
L
T
D
N
S
S
L
A
Y
S
20
      TM1        
E
Q
C
G
Q
E
T
P
L
E
30
                   
N
M
L
F
A
C
F
Y
L
L
40
                   
D
F
I
L
A
F
V
G
N
A
50
                   
L
A
L
W
L
F
I
W
D
H
60
ICL1 TM2      
K
S
G
T
P
A
N
V
F
L
70
                   
M
H
L
A
V
A
D
L
S
C
80
                   
V
L
V
L
P
T
R
L
V
Y
90
        ECL1    
H
F
S
G
N
H
W
P
F
G
100
TM3              
E
I
P
C
R
L
T
G
F
L
110
                   
F
Y
L
N
M
Y
A
S
I
Y
120
                   
F
L
T
C
I
S
A
D
R
F
130
          ICL2  
L
A
I
V
H
P
V
K
S
L
140
      TM4        
K
L
R
R
P
L
Y
A
H
L
150
                   
A
C
A
F
L
W
I
V
V
A
160
                   
V
A
M
A
P
L
L
V
S
P
170
ECL2            
Q
T
V
Q
T
N
H
T
V
V
180
        TM5      
C
L
Q
L
Y
R
E
K
A
S
190
                   
H
H
A
L
A
S
L
A
V
A
200
                   
F
T
F
P
F
I
T
T
V
T
210
                   
C
Y
L
L
I
I
R
S
L
R
220
  ICL3 TM6    
Q
G
P
R
I
E
K
H
L
K
230
                   
N
K
A
V
R
M
I
A
M
V
240
                   
L
A
I
F
L
I
C
F
V
P
250
                   
Y
H
I
H
R
S
V
Y
V
L
260
        ECL3 TM7
H
Y
R
G
G
G
T
S
C
A
270
                 
A
Q
R
A
L
A
L
G
N
R
280
                   
I
T
S
C
L
T
S
L
N
G
290
                   
A
L
D
P
V
M
Y
F
F
V
300
H8                
A
E
K
F
R
H
A
L
C
N
310
        C-term
L
L
C
S
K
R
L
T
G
P
320
                   
P
P
S
F
E
G
K
T
N
E
330
                 
S
S
L
S
A
R
S
E
L

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 H K S G ICL1ECL1 N H W P F ECL1ICL2 P V K S L K L R ICL2ECL2 P Q T V Q T N H T V V C L Q L ECL2ICL3 G P R I ICL3ECL3 G G T ECL3N-term M N G L E A A L P S L T D N S S L A Y S E Q C N-termC-term K R L T G P P P S F E G K T N E S S L S A R S E L C-term G Q E T P L E N M L F A C F Y L L D F I L A F V G N A L A L W L F I W D T P A N V F L M H L A V A D L S C V L V L P T R L V Y H F S G G E I P C R L T G F L F Y L N M Y A S I Y F L T C I S A D R F L A I V H R P L Y A H L A C A F L W I V V A V A M A P L L V S Y R E K A S H H A L A S L A V A F T F P F I T T V T C Y L L I I R S L R Q E K H L K N K A V R M I A M V L A I F L I C F V P Y H I H R S V Y V L H Y R G S C A A Q R A L A L G N R I T S C L T S L N G A L D P V M Y F F V A E K L C N F R H A L L C S
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

A N G V F A L I F D L L Y F C A F L M N 1 M H L A V A D L S C V L V L P T R L V Y 2 C T L F Y I S A Y M N L Y F L F G T L R 3 A H L A C A F L W I V V A V A M A P L 4 Y C T V T T I F P F T F A V A L S A L A H 5 A M V L A I F L I C F V P Y H I H R S V 6 V P D L A G N L S T L C S T I R N G L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

LTD4, UDP-galactose, LTC4, UDP-glucose, LTE4

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available