VPAC1 receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6VN7

RESOLUTION

3.2 Å

REFERENCE

10.1038/S41467-020-17933-8

PUBLICATION DATE

Sept. 2, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

57 interactions (Click to see)

LIGANDS

[Ac-His1]PACAP-27 - Agonist gtoplig chembl_ligand pubchem

ENDOGENOUS LIGANDS

VIP, PACAP-27, secretin, PHI, PHM, GHRH, PACAP-38



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 248 - G.S3 F 219 G.S3.03
Polar TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 244 3x58 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 248 - G.H5 R 380 G.H5.12
Hydrophobic TM3 L 243 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 S 247 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 S 247 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 244 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM5 L 319 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 322 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 248 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 248 - G.S3 V 217 G.S3.01
Aromatic ICL2 F 248 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 248 - G.H5 F 376 G.H5.08
Hydrophobic TM6 R 338 6x37 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 248 - G.H5 C 379 G.H5.11
Hydrophobic ICL2 S 247 - G.H5 Q 384 G.H5.16
Aromatic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 174 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 322 5x64 G.H5 L 388 G.H5.20
Ionic TM5 K 322 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 322 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 322 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 322 5x64 G.H5 D 381 G.H5.13
Polar TM3 A 245 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 245 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 243 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 319 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 323 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 323 5x65 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 240 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 319 5x61 G.H5 L 394 G.H5.26
Aromatic ICL2 F 248 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 248 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 248 - G.S1 H 41 G.S1.02
Polar TM6 S 342 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 342 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 342 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 239 3x53 G.H5 Y 391 G.H5.23
Polar TM5 K 322 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 322 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 322 5x64 G.H5 R 385 G.H5.17