Structure information

VPAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6VN7

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

R

PUBLICATION DATE

Sept. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PACAP D132 1.29x29 TM1 polar (hydrogen bond with backbone)
PACAP D132 1.29x29 TM1 polar (charge-charge)
PACAP T136 1.33x33 TM1 polar (hydrogen bond)
PACAP Y139 1.36x36 TM1 hydrophobic
PACAP V142 1.39x39 TM1 hydrophobic
PACAP Y146 1.43x43 TM1 hydrophobic
PACAP R188 2.60x60 TM2 polar (charge-charge)
PACAP F222 3.36x36 TM3 hydrophobic
PACAP Q223 3.37x37 TM3 polar (hydrogen bond)
PACAP V226 3.40x40 TM3 hydrophobic
PACAP D287 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
PACAP I289 ECL2 polar (hydrogen bond with backbone)
PACAP W294 5.36x37 TM5 hydrophobic
PACAP M370 7.39x38 TM7 hydrophobic
PACAP L374 7.43x42 TM7 hydrophobic

Ligands

PACAP

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Residue Diagrams

L L T A L S L G Y G I T Y G T K V S G Y 1 M H L F I S F I L R A A A V F I K D L A 2 V L L W F F N A M V C Y Q F F V M A A K 3 Y F W G Y I L G I W G V P S T F T M V W T 4 F L I F N V L I S T L I P G K I I W W L S 5 L L L I P L F G V H Y I M F A F F 6 I A V V F G Q F S G V V L E F V M K V 7
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ICL1 R K L H ICL1ECL1 F D S G E S D Q C S E G ECL1ICL2 S F F ICL2ECL2 D Y G C W D T I ECL2ICL3 R P P D I R K ICL3ECL3 P D N F K ECL3N-term M R P P S P L P A R W L C V L A G A L A W A L G P A G G Q A A R L Q E E C D Y V Q M I E V Q H K Q C L E E A Q L E N E T I G C S K M W D N L T C W P A T P R G Q V V V L A C P L I F K L F S S I Q G R N V S R S C T D E G W T H L E P G P Y P I A C G L D D K A N-termC-term Y R H P S G G S N G A T C S T Q V S M L T R V S P G A R R S S S F Q A E V S L V C-term A S L D E Q Q T M F Y G S V K T G Y T I G Y G L S L A T L L V A T A I L S L F C T R N Y I H M H L F I S F I L R A A A V F I K D L A L S V G C K A A M V F F Q Y C V M A N F F W L L V E G L Y L Y T L L A V S E R K Y F W G Y I L I G W G V P S T F T M V W T I A R I H F E N S S L W W I I K G P I L T S I L V N F I L F I C I I R I L L Q K L S D S S P Y S R L A R S T L L L I P L F G V H Y I M F A F F P E V K M V F E L V V G S F Q G F V V A I L Y C F L N G E L R R W H L G W N V Q A E K W R R Q G V L P K
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Residue Table


GPCRdb(A)
GPCRdb(B)
VPAC1 receptor
TM1
1x25 1.29x29 D132
1x29 1.33x33 T136
1x32 1.36x36 Y139
1x35 1.39x39 V142
1x39 1.43x43 Y146
TM2
2x53 2.60x60 R188
TM3
3x32 3.36x36 F222
3x33 3.37x37 Q223
3x36 3.40x40 V226
ECL2
45x52 45.52x52 D287
TM5
5x41 5.36x37 W294
TM7
7x34 7.39x38 M370
7x38 7.43x42 L374