ETA receptor (ednra_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Endothelin receptors ETA receptor
GENE
EDNRA (ETA, ETRA)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Endothelin-1 receptor, Endothelin receptor type A, ET-A, ETA-R, hET-AR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
T
|
L
|
C
|
L
|
R
|
A
|
S
|
F
|
10 |
W
|
L
|
A
|
L
|
V
|
G
|
C
|
V
|
I
|
S
|
20 |
D
|
N
|
P
|
E
|
R
|
Y
|
S
|
T
|
N
|
L
|
30 |
S
|
N
|
H
|
V
|
D
|
D
|
F
|
T
|
T
|
F
|
40 |
R
|
G
|
T
|
E
|
L
|
S
|
F
|
L
|
V
|
T
|
50 |
T
|
H
|
Q
|
P
|
T
|
N
|
L
|
V
|
L
|
P
|
60 |
S
|
N
|
G
|
S
|
M
|
H
|
N
|
Y
|
C
|
P
|
70 |
TM1 | |||||||||
Q
|
Q
|
T
|
K
|
I
|
T
|
S
|
A
|
F
|
K
|
80 |
Y
|
I
|
N
|
T
|
V
|
I
|
S
|
C
|
T
|
I
|
90 |
F
|
I
|
V
|
G
|
M
|
V
|
G
|
N
|
A
|
T
|
100 |
L
|
L
|
R
|
I
|
I
|
Y
|
Q
|
N
|
K
|
C
|
110 |
ICL1 | TM2 | ||||||||
M
|
R
|
N
|
G
|
P
|
N
|
A
|
L
|
I
|
A
|
120 |
S
|
L
|
A
|
L
|
G
|
D
|
L
|
I
|
Y
|
V
|
130 |
V
|
I
|
D
|
L
|
P
|
I
|
N
|
V
|
F
|
K
|
140 |
ECL1 | |||||||||
L
|
L
|
A
|
G
|
R
|
W
|
P
|
F
|
D
|
H
|
150 |
TM3 | |||||||||
N
|
D
|
F
|
G
|
V
|
F
|
L
|
C
|
K
|
L
|
160 |
F
|
P
|
F
|
L
|
Q
|
K
|
S
|
S
|
V
|
G
|
170 |
I
|
T
|
V
|
L
|
N
|
L
|
C
|
A
|
L
|
S
|
180 |
V
|
D
|
R
|
Y
|
R
|
A
|
V
|
A
|
S
|
W
|
190 |
ICL2 | TM4 | ||||||||
S
|
R
|
V
|
Q
|
G
|
I
|
G
|
I
|
P
|
L
|
200 |
V
|
T
|
A
|
I
|
E
|
I
|
V
|
S
|
I
|
W
|
210 |
I
|
L
|
S
|
F
|
I
|
L
|
A
|
I
|
P
|
E
|
220 |
ECL2 | |||||||||
A
|
I
|
G
|
F
|
V
|
M
|
V
|
P
|
F
|
E
|
230 |
Y
|
R
|
G
|
E
|
Q
|
H
|
K
|
T
|
C
|
M
|
240 |
TM5 | |||||||||
L
|
N
|
A
|
T
|
S
|
K
|
F
|
M
|
E
|
F
|
250 |
Y
|
Q
|
D
|
V
|
K
|
D
|
W
|
W
|
L
|
F
|
260 |
G
|
F
|
Y
|
F
|
C
|
M
|
P
|
L
|
V
|
C
|
270 |
T
|
A
|
I
|
F
|
Y
|
T
|
L
|
M
|
T
|
C
|
280 |
E
|
M
|
L
|
N
|
R
|
R
|
N
|
G
|
S
|
L
|
290 |
ICL3 | TM6 | ||||||||
R
|
I
|
A
|
L
|
S
|
E
|
H
|
L
|
K
|
Q
|
300 |
R
|
R
|
E
|
V
|
A
|
K
|
T
|
V
|
F
|
C
|
310 |
L
|
V
|
V
|
I
|
F
|
A
|
L
|
C
|
W
|
F
|
320 |
P
|
L
|
H
|
L
|
S
|
R
|
I
|
L
|
K
|
K
|
330 |
ECL3 | |||||||||
T
|
V
|
Y
|
N
|
E
|
M
|
D
|
K
|
N
|
R
|
340 |
TM7 | |||||||||
C
|
E
|
L
|
L
|
S
|
F
|
L
|
L
|
L
|
M
|
350 |
D
|
Y
|
I
|
G
|
I
|
N
|
L
|
A
|
T
|
M
|
360 |
N
|
S
|
C
|
I
|
N
|
P
|
I
|
A
|
L
|
Y
|
370 |
H8 | |||||||||
F
|
V
|
S
|
K
|
K
|
F
|
K
|
N
|
C
|
F
|
380 |
Q
|
S
|
C
|
L
|
C
|
C
|
C
|
C
|
Y
|
Q
|
390 |
C-term | |||||||||
S
|
K
|
S
|
L
|
M
|
T
|
S
|
V
|
P
|
M
|
400 |
N
|
G
|
T
|
S
|
I
|
Q
|
W
|
K
|
N
|
H
|
410 |
D
|
Q
|
N
|
N
|
H
|
N
|
T
|
D
|
R
|
S
|
420 |
S
|
H
|
K
|
D
|
S
|
M
|
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
endothelin-2, endothelin-3, endothelin-1
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8HCQ