C5a1 receptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.3 Å

REFERENCE

PUBLICATION DATE

Oct. 18, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

C5a des-Arg - Agonist gtoplig

PHYSIOLOGICAL LIGANDS

ribosomal protein S19, C3a, C5a, C5a des-Arg



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E12G.h4s6C23G.H5GproteinA-R3x50N2x39GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM2TM3ICL3

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x545x656x326x336x367x567x57G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.S6.02G.h4s6.12G.S3.01G.hns1.03Res. Pos.C5a1 (8JZZ)- (8JZZ)-----------NRLVTKTVAGNRLVTKTVAGICNILGLYFTDIALYEK

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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