BLT1 receptor (lt4r1_human)

FAMILY

Class A (Rhodopsin) Lipid receptors Leukotriene receptors BLT1 receptor

GENE

LTB4R (BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Leukotriene B4 receptor 1, LTB4-R 1, LTB4-R1, Chemoattractant receptor-like 1, G-protein coupled receptor 16, P2Y purinoceptor 7, P2Y7

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
T
T
S
S
A
A
P
P
10
    TM1          
S
L
G
V
E
F
I
S
L
L
20
                   
A
I
I
L
L
S
V
A
L
A
30
                   
V
G
L
P
G
N
S
F
V
V
40
            ICL1
W
S
I
L
K
R
M
Q
K
R
50
TM2              
S
V
T
A
L
M
V
L
N
L
60
                   
A
L
A
D
L
A
V
L
L
T
70
                   
A
P
F
F
L
H
F
L
A
Q
80
  ECL1 TM3    
G
T
W
S
F
G
L
A
G
C
90
                   
R
L
C
H
Y
V
C
G
V
S
100
                   
M
Y
A
S
V
L
L
I
T
A
110
                   
M
S
L
D
R
S
L
A
V
A
120
  ICL2          
R
P
F
V
S
Q
K
L
R
T
130
TM4              
K
A
M
A
R
R
V
L
A
G
140
                   
I
W
V
L
S
F
L
L
A
T
150
            ECL2
P
V
L
A
Y
R
T
V
V
P
160
                   
W
K
T
N
M
S
L
C
F
P
170
      TM5        
R
Y
P
S
E
G
H
R
A
F
180
                   
H
L
I
F
E
A
V
T
G
F
190
                   
L
L
P
F
L
A
V
V
A
S
200
                   
Y
S
D
I
G
R
R
L
Q
A
210
  ICL3 TM6    
R
R
F
R
R
S
R
R
T
G
220
                   
R
L
V
V
L
I
I
L
T
F
230
                   
A
A
F
W
L
P
Y
H
V
V
240
                   
N
L
A
E
A
G
R
A
L
A
250
  ECL3   TM7  
G
Q
A
A
G
L
G
L
V
G
260
                   
K
R
L
S
L
A
R
N
V
L
270
                   
I
A
L
A
F
L
S
S
S
V
280
                   
N
P
V
L
Y
A
C
A
G
G
290
                   
G
L
L
R
S
A
G
V
G
F
300
C-term        
V
A
K
L
L
E
G
T
G
S
310
                   
E
A
S
S
T
R
R
G
G
S
320
                   
L
G
Q
T
A
R
S
G
P
A
330
                   
A
L
E
P
G
P
S
E
S
L
340
                   
T
A
S
S
P
L
K
L
N
E
350
   
L
N

LINKS

DIAGRAMS

ICL1 M Q K R ICL1ECL1 T W S F ECL1ICL2 P F V S Q K L R ICL2ECL2 T V V P W K T N M S L C F P R Y P ECL2ICL3 R F R R ICL3ECL3 Q A A G L ECL3N-term M N T T S S A A P P S L N-termC-term G V G F V A K L L E G T G S E A S S T R R G G S L G Q T A R S G P A A L E P G P S E S L T A S S P L K L N E L N C-term G V E F I S L L A I I L L S V A L A V G L P G N S F V V W S I L K R S V T A L M V L N L A L A D L A V L L T A P F F L H F L A Q G G L A G C R L C H Y V C G V S M Y A S V L L I T A M S L D R S L A V A R T K A M A R R V L A G I W V L S F L L A T P V L A Y R S E G H R A F H L I F E A V T G F L L P F L A V V A S Y S D I G R R L Q A R S R R T G R L V V L I I L T F A A F W L P Y H V V N L A E A G R A L A G G L V G K R L S L A R N V L I A L A F L S S S V N P V L Y A C A G G G L L R S A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N G P L G V A L A V S L L I I A L L S 1 L N L A L A D L A V L L T A P F F L H F 2 A T I L L V S A Y M S V G C V Y H C L R 3 A R R V L A G I W V L S F L L A T P V 4 Y S A V V A L F P L L F G T V A E F I L H 5 V L I I L T F A A F W L P Y H V V N L A 6 V P N V S S S L F A L A I L V N R A L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

12R-HETE, LTB4, 20-hydroxy-LTB4

STRUCTURE MODELS

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 7K15, 7VKT