BLT1 receptor (lt4r1_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Leukotriene receptors BLT1 receptor
GENE
LTB4R (BLT, BLT1, BLTR, CMKRL1, GPR16, P2RY7)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Leukotriene B4 receptor 1, LTB4-R 1, LTB4-R1, Chemoattractant receptor-like 1, G-protein coupled receptor 16, P2Y purinoceptor 7, P2Y7
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
T
|
T
|
S
|
S
|
A
|
A
|
P
|
P
|
10 |
TM1 | |||||||||
S
|
L
|
G
|
V
|
E
|
F
|
I
|
S
|
L
|
L
|
20 |
A
|
I
|
I
|
L
|
L
|
S
|
V
|
A
|
L
|
A
|
30 |
V
|
G
|
L
|
P
|
G
|
N
|
S
|
F
|
V
|
V
|
40 |
ICL1 | |||||||||
W
|
S
|
I
|
L
|
K
|
R
|
M
|
Q
|
K
|
R
|
50 |
TM2 | |||||||||
S
|
V
|
T
|
A
|
L
|
M
|
V
|
L
|
N
|
L
|
60 |
A
|
L
|
A
|
D
|
L
|
A
|
V
|
L
|
L
|
T
|
70 |
A
|
P
|
F
|
F
|
L
|
H
|
F
|
L
|
A
|
Q
|
80 |
ECL1 | TM3 | ||||||||
G
|
T
|
W
|
S
|
F
|
G
|
L
|
A
|
G
|
C
|
90 |
R
|
L
|
C
|
H
|
Y
|
V
|
C
|
G
|
V
|
S
|
100 |
M
|
Y
|
A
|
S
|
V
|
L
|
L
|
I
|
T
|
A
|
110 |
M
|
S
|
L
|
D
|
R
|
S
|
L
|
A
|
V
|
A
|
120 |
ICL2 | |||||||||
R
|
P
|
F
|
V
|
S
|
Q
|
K
|
L
|
R
|
T
|
130 |
TM4 | |||||||||
K
|
A
|
M
|
A
|
R
|
R
|
V
|
L
|
A
|
G
|
140 |
I
|
W
|
V
|
L
|
S
|
F
|
L
|
L
|
A
|
T
|
150 |
ECL2 | |||||||||
P
|
V
|
L
|
A
|
Y
|
R
|
T
|
V
|
V
|
P
|
160 |
W
|
K
|
T
|
N
|
M
|
S
|
L
|
C
|
F
|
P
|
170 |
TM5 | |||||||||
R
|
Y
|
P
|
S
|
E
|
G
|
H
|
R
|
A
|
F
|
180 |
H
|
L
|
I
|
F
|
E
|
A
|
V
|
T
|
G
|
F
|
190 |
L
|
L
|
P
|
F
|
L
|
A
|
V
|
V
|
A
|
S
|
200 |
Y
|
S
|
D
|
I
|
G
|
R
|
R
|
L
|
Q
|
A
|
210 |
ICL3 | TM6 | ||||||||
R
|
R
|
F
|
R
|
R
|
S
|
R
|
R
|
T
|
G
|
220 |
R
|
L
|
V
|
V
|
L
|
I
|
I
|
L
|
T
|
F
|
230 |
A
|
A
|
F
|
W
|
L
|
P
|
Y
|
H
|
V
|
V
|
240 |
N
|
L
|
A
|
E
|
A
|
G
|
R
|
A
|
L
|
A
|
250 |
ECL3 | TM7 | ||||||||
G
|
Q
|
A
|
A
|
G
|
L
|
G
|
L
|
V
|
G
|
260 |
K
|
R
|
L
|
S
|
L
|
A
|
R
|
N
|
V
|
L
|
270 |
I
|
A
|
L
|
A
|
F
|
L
|
S
|
S
|
S
|
V
|
280 |
N
|
P
|
V
|
L
|
Y
|
A
|
C
|
A
|
G
|
G
|
290 |
G
|
L
|
L
|
R
|
S
|
A
|
G
|
V
|
G
|
F
|
300 |
C-term | |||||||||
V
|
A
|
K
|
L
|
L
|
E
|
G
|
T
|
G
|
S
|
310 |
E
|
A
|
S
|
S
|
T
|
R
|
R
|
G
|
G
|
S
|
320 |
L
|
G
|
Q
|
T
|
A
|
R
|
S
|
G
|
P
|
A
|
330 |
A
|
L
|
E
|
P
|
G
|
P
|
S
|
E
|
S
|
L
|
340 |
T
|
A
|
S
|
S
|
P
|
L
|
K
|
L
|
N
|
E
|
350 |
L
|
N
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
12R-HETE, LTB4, 20-hydroxy-LTB4
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page