5-HT4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

5-hydroxytryptamine - Agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 L 260 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 260 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 I 214 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 214 5x61 G.H5 L 353 G.H5.25
Polar TM6 A 256 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 256 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 126 - G.H5 I 343 G.H5.15
Hydrophobic TM5 H 221 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 H 221 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 N 130 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 N 130 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 126 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 126 - G.S3 L 194 G.S3.01
Polar TM3 R 117 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 120 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 259 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 121 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 117 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 117 3x50 G.H5 L 353 G.H5.25
Van-der-waals ICL2 V 127 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 121 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 121 3x54 G.H5 C 351 G.H5.23
Hydrophobic H8 N 315 8x47 G.H5 G 352 G.H5.24
Polar TM3 A 120 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 120 3x53 G.H5 N 347 G.H5.19
Ionic ICL2 K 131 - G.HN E 28 G.HN.52
Polar ICL2 K 131 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 131 - G.HN E 28 G.HN.52
Van-der-waals ICL2 K 131 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 121 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 121 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 218 5x65 G.H5 L 348 G.H5.20
Polar ICL2 P 125 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 125 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 125 - G.H5 N 347 G.H5.19
Hydrophobic TM5 H 221 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 221 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 126 - G.S1 V 34 G.S1.02
Polar TM5 H 221 5x68 G.H5 T 340 G.H5.12