CXCR2 (cxcr2_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors CXCR2
GENE
CXCR2 (IL8RB)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CDw128b, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8R B, IL-8 receptor type 2, CD182
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
E
|
D
|
F
|
N
|
M
|
E
|
S
|
D
|
S
|
10 |
F
|
E
|
D
|
F
|
W
|
K
|
G
|
E
|
D
|
L
|
20 |
S
|
N
|
Y
|
S
|
Y
|
S
|
S
|
T
|
L
|
P
|
30 |
P
|
F
|
L
|
L
|
D
|
A
|
A
|
P
|
C
|
E
|
40 |
TM1 | |||||||||
P
|
E
|
S
|
L
|
E
|
I
|
N
|
K
|
Y
|
F
|
50 |
V
|
V
|
I
|
I
|
Y
|
A
|
L
|
V
|
F
|
L
|
60 |
L
|
S
|
L
|
L
|
G
|
N
|
S
|
L
|
V
|
M
|
70 |
ICL1 | |||||||||
L
|
V
|
I
|
L
|
Y
|
S
|
R
|
V
|
G
|
R
|
80 |
TM2 | |||||||||
S
|
V
|
T
|
D
|
V
|
Y
|
L
|
L
|
N
|
L
|
90 |
A
|
L
|
A
|
D
|
L
|
L
|
F
|
A
|
L
|
T
|
100 |
L
|
P
|
I
|
W
|
A
|
A
|
S
|
K
|
V
|
N
|
110 |
ECL1 | TM3 | ||||||||
G
|
W
|
I
|
F
|
G
|
T
|
F
|
L
|
C
|
K
|
120 |
V
|
V
|
S
|
L
|
L
|
K
|
E
|
V
|
N
|
F
|
130 |
Y
|
S
|
G
|
I
|
L
|
L
|
L
|
A
|
C
|
I
|
140 |
S
|
V
|
D
|
R
|
Y
|
L
|
A
|
I
|
V
|
H
|
150 |
ICL2 | |||||||||
A
|
T
|
R
|
T
|
L
|
T
|
Q
|
K
|
R
|
Y
|
160 |
TM4 | |||||||||
L
|
V
|
K
|
F
|
I
|
C
|
L
|
S
|
I
|
W
|
170 |
G
|
L
|
S
|
L
|
L
|
L
|
A
|
L
|
P
|
V
|
180 |
ECL2 | |||||||||
L
|
L
|
F
|
R
|
R
|
T
|
V
|
Y
|
S
|
S
|
190 |
N
|
V
|
S
|
P
|
A
|
C
|
Y
|
E
|
D
|
M
|
200 |
TM5 | |||||||||
G
|
N
|
N
|
T
|
A
|
N
|
W
|
R
|
M
|
L
|
210 |
L
|
R
|
I
|
L
|
P
|
Q
|
S
|
F
|
G
|
F
|
220 |
I
|
V
|
P
|
L
|
L
|
I
|
M
|
L
|
F
|
C
|
230 |
Y
|
G
|
F
|
T
|
L
|
R
|
T
|
L
|
F
|
K
|
240 |
ICL3 | TM6 | ||||||||
A
|
H
|
M
|
G
|
Q
|
K
|
H
|
R
|
A
|
M
|
250 |
R
|
V
|
I
|
F
|
A
|
V
|
V
|
L
|
I
|
F
|
260 |
L
|
L
|
C
|
W
|
L
|
P
|
Y
|
N
|
L
|
V
|
270 |
L
|
L
|
A
|
D
|
T
|
L
|
M
|
R
|
T
|
Q
|
280 |
ECL3 | TM7 | ||||||||
V
|
I
|
Q
|
E
|
T
|
C
|
E
|
R
|
R
|
N
|
290 |
H
|
I
|
D
|
R
|
A
|
L
|
D
|
A
|
T
|
E
|
300 |
I
|
L
|
G
|
I
|
L
|
H
|
S
|
C
|
L
|
N
|
310 |
H8 | |||||||||
P
|
L
|
I
|
Y
|
A
|
F
|
I
|
G
|
Q
|
K
|
320 |
F
|
R
|
H
|
G
|
L
|
L
|
K
|
I
|
L
|
A
|
330 |
C-term | |||||||||
I
|
H
|
G
|
L
|
I
|
S
|
K
|
D
|
S
|
L
|
340 |
P
|
K
|
D
|
S
|
R
|
P
|
S
|
F
|
V
|
G
|
350 |
S
|
S
|
S
|
G
|
H
|
T
|
S
|
T
|
T
|
L
|
360 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CXCL3, CXCL8, CXCL7, CXCL2, CXCL1, CXCL6, CXCL5
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page