D4 receptor (drd4_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Dopamine receptors D4 receptor
GENE
DRD4
ORGANISM
Human (Homo sapiens)
ALT. NAMES
D(4) dopamine receptor, D(2C) dopamine receptor, Dopamine D4 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
N
|
R
|
S
|
T
|
A
|
D
|
A
|
D
|
10 |
G
|
L
|
L
|
A
|
G
|
R
|
G
|
P
|
A
|
A
|
20 |
G
|
A
|
S
|
A
|
G
|
A
|
S
|
A
|
G
|
L
|
30 |
TM1 | |||||||||
A
|
G
|
Q
|
G
|
A
|
A
|
A
|
L
|
V
|
G
|
40 |
G
|
V
|
L
|
L
|
I
|
G
|
A
|
V
|
L
|
A
|
50 |
G
|
N
|
S
|
L
|
V
|
C
|
V
|
S
|
V
|
A
|
60 |
ICL1 | TM2 | ||||||||
T
|
E
|
R
|
A
|
L
|
Q
|
T
|
P
|
T
|
N
|
70 |
S
|
F
|
I
|
V
|
S
|
L
|
A
|
A
|
A
|
D
|
80 |
L
|
L
|
L
|
A
|
L
|
L
|
V
|
L
|
P
|
L
|
90 |
F
|
V
|
Y
|
S
|
E
|
V
|
Q
|
G
|
G
|
A
|
100 |
ECL1 | TM3 | ||||||||
W
|
L
|
L
|
S
|
P
|
R
|
L
|
C
|
D
|
A
|
110 |
L
|
M
|
A
|
M
|
D
|
V
|
M
|
L
|
C
|
T
|
120 |
A
|
S
|
I
|
F
|
N
|
L
|
C
|
A
|
I
|
S
|
130 |
V
|
D
|
R
|
F
|
V
|
A
|
V
|
A
|
V
|
P
|
140 |
ICL2 | TM4 | ||||||||
L
|
R
|
Y
|
N
|
R
|
Q
|
G
|
G
|
S
|
R
|
150 |
R
|
Q
|
L
|
L
|
L
|
I
|
G
|
A
|
T
|
W
|
160 |
L
|
L
|
S
|
A
|
A
|
V
|
A
|
A
|
P
|
V
|
170 |
ECL2 | |||||||||
L
|
C
|
G
|
L
|
N
|
D
|
V
|
R
|
G
|
R
|
180 |
D
|
P
|
A
|
V
|
C
|
R
|
L
|
E
|
D
|
R
|
190 |
TM5 | |||||||||
D
|
Y
|
V
|
V
|
Y
|
S
|
S
|
V
|
C
|
S
|
200 |
F
|
F
|
L
|
P
|
C
|
P
|
L
|
M
|
L
|
L
|
210 |
L
|
Y
|
W
|
A
|
T
|
F
|
R
|
G
|
L
|
Q
|
220 |
R
|
W
|
E
|
V
|
A
|
R
|
R
|
A
|
K
|
L
|
230 |
ICL3 | |||||||||
H
|
G
|
R
|
A
|
P
|
R
|
R
|
P
|
S
|
G
|
240 |
P
|
G
|
P
|
P
|
S
|
P
|
T
|
P
|
P
|
A
|
250 |
P
|
R
|
L
|
P
|
Q
|
D
|
P
|
C
|
G
|
P
|
260 |
D
|
C
|
A
|
P
|
P
|
A
|
P
|
G
|
L
|
P
|
270 |
R
|
G
|
P
|
C
|
G
|
P
|
D
|
C
|
A
|
P
|
280 |
A
|
A
|
P
|
S
|
L
|
P
|
Q
|
D
|
P
|
C
|
290 |
G
|
P
|
D
|
C
|
A
|
P
|
P
|
A
|
P
|
G
|
300 |
L
|
P
|
P
|
D
|
P
|
C
|
G
|
S
|
N
|
C
|
310 |
A
|
P
|
P
|
D
|
A
|
V
|
R
|
A
|
A
|
A
|
320 |
L
|
P
|
P
|
Q
|
T
|
P
|
P
|
Q
|
T
|
R
|
330 |
TM6 | |||||||||
R
|
R
|
R
|
R
|
A
|
K
|
I
|
T
|
G
|
R
|
340 |
E
|
R
|
K
|
A
|
M
|
R
|
V
|
L
|
P
|
V
|
350 |
V
|
V
|
G
|
A
|
F
|
L
|
L
|
C
|
W
|
T
|
360 |
P
|
F
|
F
|
V
|
V
|
H
|
I
|
T
|
Q
|
A
|
370 |
ECL3 | TM7 | ||||||||
L
|
C
|
P
|
A
|
C
|
S
|
V
|
P
|
P
|
R
|
380 |
L
|
V
|
S
|
A
|
V
|
T
|
W
|
L
|
G
|
Y
|
390 |
V
|
N
|
S
|
A
|
L
|
N
|
P
|
V
|
I
|
Y
|
400 |
H8 | |||||||||
T
|
V
|
F
|
N
|
A
|
E
|
F
|
R
|
N
|
V
|
410 |
F
|
R
|
K
|
A
|
L
|
R
|
A
|
C
|
C
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
dopamine
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page