ACKR4 (ackr4_human)
FAMILY
Class A (Rhodopsin) Protein receptors Chemokine receptors ACKR4
GENE
ACKR4 (CCBP2, CCR11, CCRL1, VSHK1)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Atypical chemokine receptor 4, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
L
|
E
|
Q
|
N
|
Q
|
S
|
T
|
D
|
10 |
Y
|
Y
|
Y
|
E
|
E
|
N
|
E
|
M
|
N
|
G
|
20 |
T
|
Y
|
D
|
Y
|
S
|
Q
|
Y
|
E
|
L
|
I
|
30 |
TM1 | |||||||||
C
|
I
|
K
|
E
|
D
|
V
|
R
|
E
|
F
|
A
|
40 |
K
|
V
|
F
|
L
|
P
|
V
|
F
|
L
|
T
|
I
|
50 |
V
|
F
|
V
|
I
|
G
|
L
|
A
|
G
|
N
|
S
|
60 |
M
|
V
|
V
|
A
|
I
|
Y
|
A
|
Y
|
Y
|
K
|
70 |
ICL1 | TM2 | ||||||||
K
|
Q
|
R
|
T
|
K
|
T
|
D
|
V
|
Y
|
I
|
80 |
L
|
N
|
L
|
A
|
V
|
A
|
D
|
L
|
L
|
L
|
90 |
L
|
F
|
T
|
L
|
P
|
F
|
W
|
A
|
V
|
N
|
100 |
ECL1 | TM3 | ||||||||
A
|
V
|
H
|
G
|
W
|
V
|
L
|
G
|
K
|
I
|
110 |
M
|
C
|
K
|
I
|
T
|
S
|
A
|
L
|
Y
|
T
|
120 |
L
|
N
|
F
|
V
|
S
|
G
|
M
|
Q
|
F
|
L
|
130 |
A
|
C
|
I
|
S
|
I
|
D
|
R
|
Y
|
V
|
A
|
140 |
ICL2 | |||||||||
V
|
T
|
K
|
V
|
P
|
S
|
Q
|
S
|
G
|
V
|
150 |
TM4 | |||||||||
G
|
K
|
P
|
C
|
W
|
I
|
I
|
C
|
F
|
C
|
160 |
V
|
W
|
M
|
A
|
A
|
I
|
L
|
L
|
S
|
I
|
170 |
ECL2 | |||||||||
P
|
Q
|
L
|
V
|
F
|
Y
|
T
|
V
|
N
|
D
|
180 |
N
|
A
|
R
|
C
|
I
|
P
|
I
|
F
|
P
|
R
|
190 |
TM5 | |||||||||
Y
|
L
|
G
|
T
|
S
|
M
|
K
|
A
|
L
|
I
|
200 |
Q
|
M
|
L
|
E
|
I
|
C
|
I
|
G
|
F
|
V
|
210 |
V
|
P
|
F
|
L
|
I
|
M
|
G
|
V
|
C
|
Y
|
220 |
F
|
I
|
T
|
A
|
R
|
T
|
L
|
M
|
K
|
M
|
230 |
ICL3 | TM6 | ||||||||
P
|
N
|
I
|
K
|
I
|
S
|
R
|
P
|
L
|
K
|
240 |
V
|
L
|
L
|
T
|
V
|
V
|
I
|
V
|
F
|
I
|
250 |
V
|
T
|
Q
|
L
|
P
|
Y
|
N
|
I
|
V
|
K
|
260 |
F
|
C
|
R
|
A
|
I
|
D
|
I
|
I
|
Y
|
S
|
270 |
ECL3 | TM7 | ||||||||
L
|
I
|
T
|
S
|
C
|
N
|
M
|
S
|
K
|
R
|
280 |
M
|
D
|
I
|
A
|
I
|
Q
|
V
|
T
|
E
|
S
|
290 |
I
|
A
|
L
|
F
|
H
|
S
|
C
|
L
|
N
|
P
|
300 |
H8 | |||||||||
I
|
L
|
Y
|
V
|
F
|
M
|
G
|
A
|
S
|
F
|
310 |
K
|
N
|
Y
|
V
|
M
|
K
|
V
|
A
|
K
|
K
|
320 |
Y
|
G
|
S
|
W
|
R
|
R
|
Q
|
R
|
Q
|
S
|
330 |
C-term | |||||||||
V
|
E
|
E
|
F
|
P
|
F
|
D
|
S
|
E
|
G
|
340 |
P
|
T
|
E
|
P
|
T
|
S
|
T
|
F
|
S
|
I
|
350 |
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL21, CCL25, CCL19
STRUCTURE MODELS
STRUCTURES
No structures available