S1P4 receptor (s1pr4_human)
FAMILY
Class A (Rhodopsin) Lipid receptors Lysophospholipid (S1P) receptors S1P4 receptor
GENE
S1PR4 (EDG6)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Sphingosine 1-phosphate receptor 4, S1P receptor 4, S1P4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6, S1P receptor Edg-6
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
A
|
T
|
G
|
T
|
P
|
V
|
A
|
P
|
10 |
E
|
S
|
C
|
Q
|
Q
|
L
|
A
|
A
|
G
|
G
|
20 |
H
|
S
|
R
|
L
|
I
|
V
|
L
|
H
|
Y
|
N
|
30 |
H
|
S
|
G
|
R
|
L
|
A
|
G
|
R
|
G
|
G
|
40 |
TM1 | |||||||||
P
|
E
|
D
|
G
|
G
|
L
|
G
|
A
|
L
|
R
|
50 |
G
|
L
|
S
|
V
|
A
|
A
|
S
|
C
|
L
|
V
|
60 |
V
|
L
|
E
|
N
|
L
|
L
|
V
|
L
|
A
|
A
|
70 |
ICL1 | |||||||||
I
|
T
|
S
|
H
|
M
|
R
|
S
|
R
|
R
|
W
|
80 |
TM2 | |||||||||
V
|
Y
|
Y
|
C
|
L
|
V
|
N
|
I
|
T
|
L
|
90 |
S
|
D
|
L
|
L
|
T
|
G
|
A
|
A
|
Y
|
L
|
100 |
ECL1 | |||||||||
A
|
N
|
V
|
L
|
L
|
S
|
G
|
A
|
R
|
T
|
110 |
TM3 | |||||||||
F
|
R
|
L
|
A
|
P
|
A
|
Q
|
W
|
F
|
L
|
120 |
R
|
E
|
G
|
L
|
L
|
F
|
T
|
A
|
L
|
A
|
130 |
A
|
S
|
T
|
F
|
S
|
L
|
L
|
F
|
T
|
A
|
140 |
G
|
E
|
R
|
F
|
A
|
T
|
M
|
V
|
R
|
P
|
150 |
ICL2 | TM4 | ||||||||
V
|
A
|
E
|
S
|
G
|
A
|
T
|
K
|
T
|
S
|
160 |
R
|
V
|
Y
|
G
|
F
|
I
|
G
|
L
|
C
|
W
|
170 |
L
|
L
|
A
|
A
|
L
|
L
|
G
|
M
|
L
|
P
|
180 |
ECL2 | |||||||||
L
|
L
|
G
|
W
|
N
|
C
|
L
|
C
|
A
|
F
|
190 |
D
|
R
|
C
|
S
|
S
|
L
|
L
|
P
|
L
|
Y
|
200 |
TM5 | |||||||||
S
|
K
|
R
|
Y
|
I
|
L
|
F
|
C
|
L
|
V
|
210 |
I
|
F
|
A
|
G
|
V
|
L
|
A
|
T
|
I
|
M
|
220 |
G
|
L
|
Y
|
G
|
A
|
I
|
F
|
R
|
L
|
V
|
230 |
ICL3 | |||||||||
Q
|
A
|
S
|
G
|
Q
|
K
|
A
|
P
|
R
|
P
|
240 |
TM6 | |||||||||
A
|
A
|
R
|
R
|
K
|
A
|
R
|
R
|
L
|
L
|
250 |
K
|
T
|
V
|
L
|
M
|
I
|
L
|
L
|
A
|
F
|
260 |
L
|
V
|
C
|
W
|
G
|
P
|
L
|
F
|
G
|
L
|
270 |
L
|
L
|
A
|
D
|
V
|
F
|
G
|
S
|
N
|
L
|
280 |
ECL3 | TM7 | ||||||||
W
|
A
|
Q
|
E
|
Y
|
L
|
R
|
G
|
M
|
D
|
290 |
W
|
I
|
L
|
A
|
L
|
A
|
V
|
L
|
N
|
S
|
300 |
A
|
V
|
N
|
P
|
I
|
I
|
Y
|
S
|
F
|
R
|
310 |
H8 | |||||||||
S
|
R
|
E
|
V
|
C
|
R
|
A
|
V
|
L
|
S
|
320 |
C-term | |||||||||
F
|
L
|
C
|
C
|
G
|
C
|
L
|
R
|
L
|
G
|
330 |
M
|
R
|
G
|
P
|
G
|
D
|
C
|
L
|
A
|
R
|
340 |
A
|
V
|
E
|
A
|
H
|
S
|
G
|
A
|
S
|
T
|
350 |
T
|
D
|
S
|
S
|
L
|
R
|
P
|
R
|
D
|
S
|
360 |
F
|
R
|
G
|
S
|
R
|
S
|
L
|
S
|
F
|
R
|
370 |
M
|
R
|
E
|
P
|
L
|
S
|
S
|
I
|
S
|
S
|
380 |
V
|
R
|
S
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosine 1-phosphate, dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine
STRUCTURE MODELS
STRUCTURES
No structures available