VPAC1 receptor (vipr1_human)
FAMILY
Class B1 (Secretin) Peptide receptors VIP and PACAP receptors VPAC1 receptor
GENE
VIPR1
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Vasoactive intestinal polypeptide receptor 1, VIP-R-1, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, PACAP-R-2, PACAP-R2, VPAC1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
P
|
P
|
S
|
P
|
L
|
P
|
A
|
R
|
10 |
W
|
L
|
C
|
V
|
L
|
A
|
G
|
A
|
L
|
A
|
20 |
W
|
A
|
L
|
G
|
P
|
A
|
G
|
G
|
Q
|
A
|
30 |
A
|
R
|
L
|
Q
|
E
|
E
|
C
|
D
|
Y
|
V
|
40 |
Q
|
M
|
I
|
E
|
V
|
Q
|
H
|
K
|
Q
|
C
|
50 |
L
|
E
|
E
|
A
|
Q
|
L
|
E
|
N
|
E
|
T
|
60 |
I
|
G
|
C
|
S
|
K
|
M
|
W
|
D
|
N
|
L
|
70 |
T
|
C
|
W
|
P
|
A
|
T
|
P
|
R
|
G
|
Q
|
80 |
V
|
V
|
V
|
L
|
A
|
C
|
P
|
L
|
I
|
F
|
90 |
K
|
L
|
F
|
S
|
S
|
I
|
Q
|
G
|
R
|
N
|
100 |
V
|
S
|
R
|
S
|
C
|
T
|
D
|
E
|
G
|
W
|
110 |
T
|
H
|
L
|
E
|
P
|
G
|
P
|
Y
|
P
|
I
|
120 |
A
|
C
|
G
|
L
|
D
|
D
|
K
|
A
|
A
|
S
|
130 |
TM1 | |||||||||
L
|
D
|
E
|
Q
|
Q
|
T
|
M
|
F
|
Y
|
G
|
140 |
S
|
V
|
K
|
T
|
G
|
Y
|
T
|
I
|
G
|
Y
|
150 |
G
|
L
|
S
|
L
|
A
|
T
|
L
|
L
|
V
|
A
|
160 |
T
|
A
|
I
|
L
|
S
|
L
|
F
|
R
|
K
|
L
|
170 |
ICL1 | TM2 | ||||||||
H
|
C
|
T
|
R
|
N
|
Y
|
I
|
H
|
M
|
H
|
180 |
L
|
F
|
I
|
S
|
F
|
I
|
L
|
R
|
A
|
A
|
190 |
A
|
V
|
F
|
I
|
K
|
D
|
L
|
A
|
L
|
F
|
200 |
ECL1 | |||||||||
D
|
S
|
G
|
E
|
S
|
D
|
Q
|
C
|
S
|
E
|
210 |
TM3 | |||||||||
G
|
S
|
V
|
G
|
C
|
K
|
A
|
A
|
M
|
V
|
220 |
F
|
F
|
Q
|
Y
|
C
|
V
|
M
|
A
|
N
|
F
|
230 |
F
|
W
|
L
|
L
|
V
|
E
|
G
|
L
|
Y
|
L
|
240 |
ICL2 | |||||||||
Y
|
T
|
L
|
L
|
A
|
V
|
S
|
F
|
F
|
S
|
250 |
TM4 | |||||||||
E
|
R
|
K
|
Y
|
F
|
W
|
G
|
Y
|
I
|
L
|
260 |
I
|
G
|
W
|
G
|
V
|
P
|
S
|
T
|
F
|
T
|
270 |
M
|
V
|
W
|
T
|
I
|
A
|
R
|
I
|
H
|
F
|
280 |
ECL2 | |||||||||
E
|
D
|
Y
|
G
|
C
|
W
|
D
|
T
|
I
|
N
|
290 |
TM5 | |||||||||
S
|
S
|
L
|
W
|
W
|
I
|
I
|
K
|
G
|
P
|
300 |
I
|
L
|
T
|
S
|
I
|
L
|
V
|
N
|
F
|
I
|
310 |
L
|
F
|
I
|
C
|
I
|
I
|
R
|
I
|
L
|
L
|
320 |
ICL3 | |||||||||
Q
|
K
|
L
|
R
|
P
|
P
|
D
|
I
|
R
|
K
|
330 |
TM6 | |||||||||
S
|
D
|
S
|
S
|
P
|
Y
|
S
|
R
|
L
|
A
|
340 |
R
|
S
|
T
|
L
|
L
|
L
|
I
|
P
|
L
|
F
|
350 |
G
|
V
|
H
|
Y
|
I
|
M
|
F
|
A
|
F
|
F
|
360 |
ECL3 | TM7 | ||||||||
P
|
D
|
N
|
F
|
K
|
P
|
E
|
V
|
K
|
M
|
370 |
V
|
F
|
E
|
L
|
V
|
V
|
G
|
S
|
F
|
Q
|
380 |
G
|
F
|
V
|
V
|
A
|
I
|
L
|
Y
|
C
|
F
|
390 |
H8 | |||||||||
L
|
N
|
G
|
E
|
V
|
Q
|
A
|
E
|
L
|
R
|
400 |
R
|
K
|
W
|
R
|
R
|
W
|
H
|
L
|
Q
|
G
|
410 |
V
|
L
|
G
|
W
|
N
|
P
|
K
|
Y
|
R
|
H
|
420 |
C-term | |||||||||
P
|
S
|
G
|
G
|
S
|
N
|
G
|
A
|
T
|
C
|
430 |
S
|
T
|
Q
|
V
|
S
|
M
|
L
|
T
|
R
|
V
|
440 |
S
|
P
|
G
|
A
|
R
|
R
|
S
|
S
|
S
|
F
|
450 |
Q
|
A
|
E
|
V
|
S
|
L
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PHM, GHRH, VIP, PACAP-27, PHI, secretin, PACAP-38
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page