GPR183 (gp183_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR183
GENE
GPR183 (EBI2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
G-protein coupled receptor 183, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2, hEBI2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
I
|
Q
|
M
|
A
|
N
|
N
|
F
|
T
|
10 |
P
|
P
|
S
|
A
|
T
|
P
|
Q
|
G
|
N
|
D
|
20 |
TM1 | |||||||||
C
|
D
|
L
|
Y
|
A
|
H
|
H
|
S
|
T
|
A
|
30 |
R
|
I
|
V
|
M
|
P
|
L
|
H
|
Y
|
S
|
L
|
40 |
V
|
F
|
I
|
I
|
G
|
L
|
V
|
G
|
N
|
L
|
50 |
L
|
A
|
L
|
V
|
V
|
I
|
V
|
Q
|
N
|
R
|
60 |
ICL1 | TM2 | ||||||||
K
|
K
|
I
|
N
|
S
|
T
|
T
|
L
|
Y
|
S
|
70 |
T
|
N
|
L
|
V
|
I
|
S
|
D
|
I
|
L
|
F
|
80 |
T
|
T
|
A
|
L
|
P
|
T
|
R
|
I
|
A
|
Y
|
90 |
ECL1 | |||||||||
Y
|
A
|
M
|
G
|
F
|
D
|
W
|
R
|
I
|
G
|
100 |
TM3 | |||||||||
D
|
A
|
L
|
C
|
R
|
I
|
T
|
A
|
L
|
V
|
110 |
F
|
Y
|
I
|
N
|
T
|
Y
|
A
|
G
|
V
|
N
|
120 |
F
|
M
|
T
|
C
|
L
|
S
|
I
|
D
|
R
|
F
|
130 |
ICL2 | |||||||||
I
|
A
|
V
|
V
|
H
|
P
|
L
|
R
|
Y
|
N
|
140 |
TM4 | |||||||||
K
|
I
|
K
|
R
|
I
|
E
|
H
|
A
|
K
|
G
|
150 |
V
|
C
|
I
|
F
|
V
|
W
|
I
|
L
|
V
|
F
|
160 |
A
|
Q
|
T
|
L
|
P
|
L
|
L
|
I
|
N
|
P
|
170 |
ECL2 | |||||||||
M
|
S
|
K
|
Q
|
E
|
A
|
E
|
R
|
I
|
T
|
180 |
C
|
M
|
E
|
Y
|
P
|
N
|
F
|
E
|
E
|
T
|
190 |
TM5 | |||||||||
K
|
S
|
L
|
P
|
W
|
I
|
L
|
L
|
G
|
A
|
200 |
C
|
F
|
I
|
G
|
Y
|
V
|
L
|
P
|
L
|
I
|
210 |
I
|
I
|
L
|
I
|
C
|
Y
|
S
|
Q
|
I
|
C
|
220 |
C
|
K
|
L
|
F
|
R
|
T
|
A
|
K
|
Q
|
N
|
230 |
ICL3 | TM6 | ||||||||
P
|
L
|
T
|
E
|
K
|
S
|
G
|
V
|
N
|
K
|
240 |
K
|
A
|
L
|
N
|
T
|
I
|
I
|
L
|
I
|
I
|
250 |
V
|
V
|
F
|
V
|
L
|
C
|
F
|
T
|
P
|
Y
|
260 |
H
|
V
|
A
|
I
|
I
|
Q
|
H
|
M
|
I
|
K
|
270 |
ECL3 | |||||||||
K
|
L
|
R
|
F
|
S
|
N
|
F
|
L
|
E
|
C
|
280 |
TM7 | |||||||||
S
|
Q
|
R
|
H
|
S
|
F
|
Q
|
I
|
S
|
L
|
290 |
H
|
F
|
T
|
V
|
C
|
L
|
M
|
N
|
F
|
N
|
300 |
C
|
C
|
M
|
D
|
P
|
F
|
I
|
Y
|
F
|
F
|
310 |
H8 | |||||||||
A
|
C
|
K
|
G
|
Y
|
K
|
R
|
K
|
V
|
M
|
320 |
R
|
M
|
L
|
K
|
R
|
Q
|
V
|
S
|
V
|
S
|
330 |
C-term | |||||||||
I
|
S
|
S
|
A
|
V
|
K
|
S
|
A
|
P
|
E
|
340 |
E
|
N
|
S
|
R
|
E
|
M
|
T
|
E
|
T
|
Q
|
350 |
M
|
M
|
I
|
H
|
S
|
K
|
S
|
S
|
N
|
G
|
360 |
K
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
27-hydroxycholesterol, 25-hydroxycholesterol, 7α,27-dihydroxycholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, 7β, 25-dihydroxycholesterol, 7α,25-dihydroxycholesterol, 7β, 27-dihydroxycholesterol
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page