GPR183 (gp183_human)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans GPR183

GENE

GPR183 (EBI2)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

G-protein coupled receptor 183, Epstein-Barr virus-induced G-protein coupled receptor 2, EBI2, EBV-induced G-protein coupled receptor 2, hEBI2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
D
I
Q
M
A
N
N
F
T
10
                   
P
P
S
A
T
P
Q
G
N
D
20
          TM1    
C
D
L
Y
A
H
H
S
T
A
30
                   
R
I
V
M
P
L
H
Y
S
L
40
                   
V
F
I
I
G
L
V
G
N
L
50
                   
L
A
L
V
V
I
V
Q
N
R
60
ICL1 TM2      
K
K
I
N
S
T
T
L
Y
S
70
                   
T
N
L
V
I
S
D
I
L
F
80
                   
T
T
A
L
P
T
R
I
A
Y
90
        ECL1    
Y
A
M
G
F
D
W
R
I
G
100
TM3              
D
A
L
C
R
I
T
A
L
V
110
                   
F
Y
I
N
T
Y
A
G
V
N
120
                   
F
M
T
C
L
S
I
D
R
F
130
          ICL2  
I
A
V
V
H
P
L
R
Y
N
140
      TM4        
K
I
K
R
I
E
H
A
K
G
150
                   
V
C
I
F
V
W
I
L
V
F
160
                   
A
Q
T
L
P
L
L
I
N
P
170
ECL2            
M
S
K
Q
E
A
E
R
I
T
180
                   
C
M
E
Y
P
N
F
E
E
T
190
  TM5            
K
S
L
P
W
I
L
L
G
A
200
                   
C
F
I
G
Y
V
L
P
L
I
210
                   
I
I
L
I
C
Y
S
Q
I
C
220
                   
C
K
L
F
R
T
A
K
Q
N
230
ICL3     TM6  
P
L
T
E
K
S
G
V
N
K
240
                   
K
A
L
N
T
I
I
L
I
I
250
                   
V
V
F
V
L
C
F
T
P
Y
260
                   
H
V
A
I
I
Q
H
M
I
K
270
        ECL3    
K
L
R
F
S
N
F
L
E
C
280
TM7              
S
Q
R
H
S
F
Q
I
S
L
290
                   
H
F
T
V
C
L
M
N
F
N
300
                   
C
C
M
D
P
F
I
Y
F
F
310
  H8              
A
C
K
G
Y
K
R
K
V
M
320
                   
R
M
L
K
R
Q
V
S
V
S
330
C-term        
I
S
S
A
V
K
S
A
P
E
340
                   
E
N
S
R
E
M
T
E
T
Q
350
                   
M
M
I
H
S
K
S
S
N
G
360
 
K

LINKS

DIAGRAMS

ICL1 R K K I ICL1ECL1 F D W R I ECL1ICL2 P L R Y N K I K ICL2ECL2 M S K Q E A E R I T C M E Y P N F E E T K ECL2ICL3 P L T E K S ICL3ECL3 S N F L E C ECL3N-term M D I Q M A N N F T P P S A T P Q G N D C D L Y A N-termC-term Q V S V S I S S A V K S A P E E N S R E M T E T Q M M I H S K S S N G K C-term H H S T A R I V M P L H Y S L V F I I G L V G N L L A L V V I V Q N N S T T L Y S T N L V I S D I L F T T A L P T R I A Y Y A M G G D A L C R I T A L V F Y I N T Y A G V N F M T C L S I D R F I A V V H R I E H A K G V C I F V W I L V F A Q T L P L L I N P S L P W I L L G A C F I G Y V L P L I I I L I C Y S Q I C C K L F R T A K Q N G V N K K A L N T I I L I I V V F V L C F T P Y H V A I I Q H M I K K L R F S Q R H S F Q I S L H F T V C L M N F N C C M D P F I Y F F A C K G V M R Y K R K M L K R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N G V L G I I F V L S Y H L P M V I R 1 T N L V I S D I L F T T A L P T R I A Y 2 C T M F N V G A Y T N I Y F V L A T I R 3 A K G V C I F V W I L V F A Q T L P L 4 Y C I L I I I L P L V Y G I F C A G L L I 5 I L I I V V F V L C F T P Y H V A I I Q 6 F P D M C C N F N M L C V T F H L S I 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

27-hydroxycholesterol, 25-hydroxycholesterol, 7α,27-dihydroxycholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, 7β, 25-dihydroxycholesterol, 7α,25-dihydroxycholesterol, 7β, 27-dihydroxycholesterol

STRUCTURE MODELS

STRUCTURES

Found 2 structure(s) - view all details on the Structures page

PDBs: 7TUY, 7TUZ