P2Y14 receptor (p2y14_rat)
FAMILY
Class A (Rhodopsin) Nucleotide receptors P2Y receptors P2Y14 receptor
GENE
P2ry14 (Gpr105)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
P2Y purinoceptor 14, P2Y14, G-protein coupled receptor 105, UDP-glucose receptor, VTR 15-20
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
N
|
T
|
T
|
T
|
T
|
E
|
P
|
P
|
10 |
TM1 | |||||||||
K
|
Q
|
P
|
C
|
T
|
R
|
N
|
T
|
L
|
I
|
20 |
T
|
Q
|
Q
|
I
|
I
|
P
|
M
|
L
|
Y
|
C
|
30 |
V
|
V
|
F
|
I
|
T
|
G
|
V
|
L
|
L
|
N
|
40 |
G
|
I
|
S
|
G
|
W
|
I
|
F
|
F
|
Y
|
V
|
50 |
ICL1 | TM2 | ||||||||
P
|
S
|
S
|
K
|
S
|
F
|
I
|
I
|
Y
|
L
|
60 |
K
|
N
|
I
|
V
|
V
|
A
|
D
|
F
|
L
|
M
|
70 |
G
|
L
|
T
|
F
|
P
|
F
|
K
|
V
|
L
|
S
|
80 |
ECL1 | TM3 | ||||||||
D
|
S
|
G
|
L
|
G
|
P
|
W
|
Q
|
L
|
N
|
90 |
V
|
F
|
V
|
F
|
R
|
V
|
S
|
A
|
V
|
I
|
100 |
F
|
Y
|
V
|
N
|
M
|
Y
|
V
|
S
|
I
|
A
|
110 |
F
|
F
|
G
|
L
|
I
|
S
|
F
|
D
|
R
|
Y
|
120 |
ICL2 | |||||||||
Y
|
K
|
I
|
V
|
K
|
P
|
L
|
L
|
V
|
S
|
130 |
TM4 | |||||||||
I
|
V
|
Q
|
S
|
V
|
N
|
Y
|
S
|
K
|
V
|
140 |
L
|
S
|
V
|
L
|
V
|
W
|
V
|
L
|
M
|
L
|
150 |
L
|
L
|
A
|
V
|
P
|
N
|
I
|
I
|
L
|
T
|
160 |
ECL2 | |||||||||
N
|
Q
|
S
|
V
|
K
|
D
|
V
|
T
|
N
|
I
|
170 |
TM5 | |||||||||
Q
|
C
|
M
|
E
|
L
|
K
|
N
|
E
|
L
|
G
|
180 |
R
|
K
|
W
|
H
|
K
|
A
|
S
|
N
|
Y
|
V
|
190 |
F
|
V
|
S
|
I
|
F
|
W
|
I
|
V
|
F
|
L
|
200 |
L
|
L
|
T
|
V
|
F
|
Y
|
M
|
A
|
I
|
T
|
210 |
R
|
K
|
I
|
F
|
K
|
S
|
H
|
L
|
K
|
S
|
220 |
TM6 | |||||||||
R
|
K
|
N
|
S
|
I
|
S
|
V
|
K
|
R
|
K
|
230 |
S
|
S
|
R
|
N
|
I
|
F
|
S
|
I
|
V
|
L
|
240 |
A
|
F
|
V
|
A
|
C
|
F
|
A
|
P
|
Y
|
H
|
250 |
V
|
A
|
R
|
I
|
P
|
Y
|
T
|
K
|
S
|
Q
|
260 |
ECL3 | TM7 | ||||||||
T
|
E
|
G
|
H
|
Y
|
S
|
C
|
Q
|
A
|
K
|
270 |
E
|
T
|
L
|
L
|
Y
|
T
|
K
|
E
|
F
|
T
|
280 |
L
|
L
|
L
|
S
|
A
|
A
|
N
|
V
|
C
|
L
|
290 |
H8 | |||||||||
D
|
P
|
I
|
S
|
I
|
S
|
S
|
Y
|
A
|
S
|
300 |
R
|
L
|
E
|
K
|
S
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
UDP N-acetyl-glucosamine, UDP, UDP-galactose, UDP-glucose, UDP-glucuronic acid
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available