EP2 receptor (pe2r2_mouse)
FAMILY
Class A (Rhodopsin) Lipid receptors Prostanoid receptors EP2 receptor
GENE
Ptger2 (Ptgerep2)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Prostaglandin E2 receptor EP2 subtype, PGE receptor EP2 subtype, PGE2 receptor EP2 subtype, Prostanoid EP2 receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
N
|
F
|
L
|
N
|
D
|
S
|
K
|
L
|
10 |
M
|
E
|
D
|
C
|
K
|
S
|
R
|
Q
|
W
|
L
|
20 |
TM1 | |||||||||
L
|
S
|
G
|
E
|
S
|
P
|
A
|
I
|
S
|
S
|
30 |
V
|
M
|
F
|
S
|
A
|
G
|
V
|
L
|
G
|
N
|
40 |
L
|
I
|
A
|
L
|
A
|
L
|
L
|
A
|
R
|
R
|
50 |
ICL1 | |||||||||
W
|
R
|
G
|
D
|
T
|
G
|
C
|
S
|
A
|
G
|
60 |
TM2 | |||||||||
S
|
R
|
T
|
S
|
I
|
S
|
L
|
F
|
H
|
V
|
70 |
L
|
V
|
T
|
E
|
L
|
V
|
L
|
T
|
D
|
L
|
80 |
L
|
G
|
T
|
C
|
L
|
I
|
S
|
P
|
V
|
V
|
90 |
L
|
A
|
S
|
Y
|
S
|
R
|
N
|
Q
|
T
|
L
|
100 |
ECL1 | TM3 | ||||||||
V
|
A
|
L
|
A
|
P
|
E
|
S
|
H
|
A
|
C
|
110 |
T
|
Y
|
F
|
A
|
F
|
T
|
M
|
T
|
F
|
F
|
120 |
S
|
L
|
A
|
T
|
M
|
L
|
M
|
L
|
F
|
A
|
130 |
M
|
A
|
L
|
E
|
R
|
Y
|
L
|
S
|
I
|
G
|
140 |
ICL2 | |||||||||
Y
|
P
|
Y
|
F
|
Y
|
R
|
R
|
H
|
L
|
S
|
150 |
TM4 | |||||||||
R
|
R
|
G
|
G
|
L
|
A
|
V
|
L
|
P
|
V
|
160 |
I
|
Y
|
G
|
A
|
S
|
L
|
L
|
F
|
C
|
S
|
170 |
ECL2 | |||||||||
L
|
P
|
L
|
L
|
N
|
Y
|
G
|
E
|
Y
|
V
|
180 |
Q
|
Y
|
C
|
P
|
G
|
T
|
W
|
C
|
F
|
I
|
190 |
TM5 | |||||||||
R
|
H
|
G
|
R
|
T
|
A
|
Y
|
L
|
Q
|
L
|
200 |
Y
|
A
|
T
|
M
|
L
|
L
|
L
|
L
|
I
|
V
|
210 |
A
|
V
|
L
|
A
|
C
|
N
|
I
|
S
|
V
|
I
|
220 |
L
|
N
|
L
|
I
|
R
|
M
|
H
|
R
|
R
|
S
|
230 |
ICL3 | |||||||||
R
|
R
|
S
|
R
|
C
|
G
|
L
|
S
|
G
|
S
|
240 |
S
|
L
|
R
|
G
|
P
|
G
|
S
|
R
|
R
|
R
|
250 |
TM6 | |||||||||
G
|
E
|
R
|
T
|
S
|
M
|
A
|
E
|
E
|
T
|
260 |
D
|
H
|
L
|
I
|
L
|
L
|
A
|
I
|
M
|
T
|
270 |
I
|
T
|
F
|
A
|
I
|
C
|
S
|
L
|
P
|
F
|
280 |
ECL3 | |||||||||
T
|
I
|
F
|
A
|
Y
|
M
|
D
|
E
|
T
|
S
|
290 |
TM7 | |||||||||
S
|
L
|
K
|
E
|
K
|
W
|
D
|
L
|
R
|
A
|
300 |
L
|
R
|
F
|
L
|
S
|
V
|
N
|
S
|
I
|
I
|
310 |
H8 | |||||||||
D
|
P
|
W
|
V
|
F
|
A
|
I
|
L
|
R
|
P
|
320 |
P
|
V
|
L
|
R
|
L
|
M
|
R
|
S
|
V
|
L
|
330 |
C-term | |||||||||
C
|
C
|
R
|
T
|
S
|
L
|
R
|
T
|
Q
|
E
|
340 |
A
|
Q
|
Q
|
T
|
S
|
C
|
S
|
T
|
Q
|
S
|
350 |
S
|
A
|
S
|
K
|
Q
|
T
|
D
|
L
|
C
|
G
|
360 |
Q
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PGE2, PGE1
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available