GHRH receptor (ghrhr_human)
FAMILY
Class B1 (Secretin) Peptide receptors Glucagon receptor family GHRH receptor
GENE
GHRHR
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
R
|
R
|
M
|
W
|
G
|
A
|
H
|
V
|
10 |
F
|
C
|
V
|
L
|
S
|
P
|
L
|
P
|
T
|
V
|
20 |
L
|
G
|
H
|
M
|
H
|
P
|
E
|
C
|
D
|
F
|
30 |
I
|
T
|
Q
|
L
|
R
|
E
|
D
|
E
|
S
|
A
|
40 |
C
|
L
|
Q
|
A
|
A
|
E
|
E
|
M
|
P
|
N
|
50 |
T
|
T
|
L
|
G
|
C
|
P
|
A
|
T
|
W
|
D
|
60 |
G
|
L
|
L
|
C
|
W
|
P
|
T
|
A
|
G
|
S
|
70 |
G
|
E
|
W
|
V
|
T
|
L
|
P
|
C
|
P
|
D
|
80 |
F
|
F
|
S
|
H
|
F
|
S
|
S
|
E
|
S
|
G
|
90 |
A
|
V
|
K
|
R
|
D
|
C
|
T
|
I
|
T
|
G
|
100 |
W
|
S
|
E
|
P
|
F
|
P
|
P
|
Y
|
P
|
V
|
110 |
TM1 | |||||||||
A
|
C
|
P
|
V
|
P
|
L
|
E
|
L
|
L
|
A
|
120 |
E
|
E
|
E
|
S
|
Y
|
F
|
S
|
T
|
V
|
K
|
130 |
I
|
I
|
Y
|
T
|
V
|
G
|
H
|
S
|
I
|
S
|
140 |
I
|
V
|
A
|
L
|
F
|
V
|
A
|
I
|
T
|
I
|
150 |
ICL1 | |||||||||
L
|
V
|
A
|
L
|
R
|
R
|
L
|
H
|
C
|
P
|
160 |
TM2 | |||||||||
R
|
N
|
Y
|
V
|
H
|
T
|
Q
|
L
|
F
|
T
|
170 |
T
|
F
|
I
|
L
|
K
|
A
|
G
|
A
|
V
|
F
|
180 |
L
|
K
|
D
|
A
|
A
|
L
|
F
|
H
|
S
|
D
|
190 |
ECL1 | |||||||||
D
|
T
|
D
|
H
|
C
|
S
|
F
|
S
|
T
|
V
|
200 |
TM3 | |||||||||
L
|
C
|
K
|
V
|
S
|
V
|
A
|
A
|
S
|
H
|
210 |
F
|
A
|
T
|
M
|
T
|
N
|
F
|
S
|
W
|
L
|
220 |
L
|
A
|
E
|
A
|
V
|
Y
|
L
|
N
|
C
|
L
|
230 |
ICL2 | |||||||||
L
|
A
|
S
|
T
|
S
|
P
|
S
|
S
|
R
|
R
|
240 |
TM4 | |||||||||
A
|
F
|
W
|
W
|
L
|
V
|
L
|
A
|
G
|
W
|
250 |
G
|
L
|
P
|
V
|
L
|
F
|
T
|
G
|
T
|
W
|
260 |
V
|
S
|
C
|
K
|
L
|
A
|
F
|
E
|
D
|
I
|
270 |
ECL2 | |||||||||
A
|
C
|
W
|
D
|
L
|
D
|
D
|
T
|
S
|
P
|
280 |
TM5 | |||||||||
Y
|
W
|
W
|
I
|
I
|
K
|
G
|
P
|
I
|
V
|
290 |
L
|
S
|
V
|
G
|
V
|
N
|
F
|
G
|
L
|
F
|
300 |
L
|
N
|
I
|
I
|
R
|
I
|
L
|
V
|
R
|
K
|
310 |
ICL3 | |||||||||
L
|
E
|
P
|
A
|
Q
|
G
|
S
|
L
|
H
|
T
|
320 |
TM6 | |||||||||
Q
|
S
|
Q
|
Y
|
W
|
R
|
L
|
S
|
K
|
S
|
330 |
T
|
L
|
F
|
L
|
I
|
P
|
L
|
F
|
G
|
I
|
340 |
H
|
Y
|
I
|
I
|
F
|
N
|
F
|
L
|
P
|
D
|
350 |
ECL3 | TM7 | ||||||||
N
|
A
|
G
|
L
|
G
|
I
|
R
|
L
|
P
|
L
|
360 |
E
|
L
|
G
|
L
|
G
|
S
|
F
|
Q
|
G
|
F
|
370 |
I
|
V
|
A
|
I
|
L
|
Y
|
C
|
F
|
L
|
N
|
380 |
H8 | |||||||||
Q
|
E
|
V
|
R
|
T
|
E
|
I
|
S
|
R
|
K
|
390 |
W
|
H
|
G
|
H
|
D
|
P
|
E
|
L
|
L
|
P
|
400 |
A
|
W
|
R
|
T
|
R
|
A
|
K
|
W
|
T
|
T
|
410 |
C-term | |||||||||
P
|
S
|
R
|
S
|
A
|
A
|
K
|
V
|
L
|
T
|
420 |
S
|
M
|
C
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
GHRH
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page