GHRH receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.6 Å

REFERENCE

PUBLICATION DATE

April 6, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

GHRH



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM5 K 246 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 K 246 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 172 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 P 172 - G.S1 H 41 G.S1.02
Hydrophobic TM5 I 242 5x60 G.H5 L 388 G.H5.20
Hydrophobic TM3 L 163 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 393 G.H5.25
Polar TM5 K 246 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 246 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 246 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 F 269 6x44 G.H5 L 393 G.H5.25
Ionic TM5 K 246 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 246 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 246 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 246 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM2 H 101 2x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 167 3x58 G.H5 H 387 G.H5.19
Hydrophobic TM5 K 246 5x64 G.H5 L 394 G.H5.26
Hydrophobic TM6 F 269 6x44 G.H5 E 392 G.H5.24
Polar TM3 E 159 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 159 3x50 G.H5 Y 391 G.H5.23
Polar H8 Q 317 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 317 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 317 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 S 173 - G.hns1 A 39 G.hns1.03
Polar TM6 R 262 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 262 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 162 3x53 G.H5 Y 391 G.H5.23
Polar TM3 L 166 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 166 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 166 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 166 3x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 172 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 T 170 - G.H5 F 376 G.H5.08
Hydrophobic TM5 L 247 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 247 5x65 G.H5 L 394 G.H5.26
Polar TM3 A 168 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 168 3x59 G.H5 R 380 G.H5.12
Polar TM5 K 246 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 246 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 246 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM6 R 262 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 167 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 167 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 L 270 6x45 G.H5 L 393 G.H5.25
Polar TM2 R 97 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 97 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 97 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM5 L 243 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 243 5x61 G.H5 L 393 G.H5.25
Hydrophobic H8 N 316 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 316 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 T 170 - G.H5 R 380 G.H5.12
Hydrophobic ICL2 T 170 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 170 - G.S3 V 217 G.S3.01
Hydrophobic TM5 L 243 5x61 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 243 5x61 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 163 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 163 3x54 G.H5 Y 391 G.H5.23
Aromatic TM2 R 97 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 97 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 97 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 239 5x57 G.H5 L 393 G.H5.25
Polar TM6 R 262 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 262 6x37 G.H5 E 392 G.H5.24
Polar TM3 L 167 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 167 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 167 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 243 5x61 G.H5 L 388 G.H5.20
Polar TM6 S 266 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 266 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 266 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 273 6x48 G.H5 Y 391 G.H5.23