mGlu2 receptor - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

2

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8JD3

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

L-glutamic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem ,

JNJ-40411813 - PAM pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 S 601 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 K 599 - G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 599 - G.H5 L 353 G.H5.25
Hydrophobic TM3 I 657 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 660 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 664 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 664 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 756 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 F 756 - G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 668 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 668 - G.H5 I 343 G.H5.15
Hydrophobic ICL1 K 599 - G.H5 G 352 G.H5.24
Van-der-waals ICL1 K 599 - G.H5 G 352 G.H5.24
Hydrophobic ICL1 K 599 - G.H5 F 354 G.H5.26
Van-der-waals ICL1 K 599 - G.H5 F 354 G.H5.26
Hydrophobic ICL1 G 602 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 F 756 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 F 756 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 660 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 660 3x57 G.H5 L 348 G.H5.20
Hydrophobic ICL2 I 674 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 674 - G.H5 C 351 G.H5.23
Hydrophobic TM3 F 661 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 660 3x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 668 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 G 667 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 667 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 668 - G.hns1 A 31 G.hns1.02
Hydrophobic TM4 P 676 4x29 G.H5 C 351 G.H5.23
Polar ICL2 A 668 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 668 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 668 - G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 660 3x57 G.H5 L 353 G.H5.25
Polar TM3 R 656 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 656 3x53 G.H5 C 351 G.H5.23
Polar ICL1 A 600 - G.H5 L 353 G.H5.25
Hydrophobic ICL1 A 600 - G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 600 - G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 671 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 671 - G.H5 N 347 G.H5.19
Ionic ICL2 R 670 - G.H5 D 350 G.H5.22
Polar ICL2 R 670 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 670 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 670 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 A 668 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 A 664 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 664 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 Q 669 - G.hns1 A 31 G.hns1.02