Structure information

mGlu2 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

8JD3

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

2

REFERENCE

10.1038/S41422-023-00830-2

PUBLICATION DATE

June 21, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JNJ-40411813 L639 3.36x36 TM3 hydrophobic
JNJ-40411813 F643 3.40x40 TM3 hydrophobic
JNJ-40411813 Y647 3.44x44 TM3 hydrophobic
JNJ-40411813 A726 5.38x38 TM5 hydrophobic
JNJ-40411813 M728 5.40x40 TM5 hydrophobic
JNJ-40411813 L732 5.44x44 TM5 hydrophobic
JNJ-40411813 N735 5.47x47 TM5 polar (hydrogen bond)
JNJ-40411813 N735 5.47x47 TM5 Van der Waals
JNJ-40411813 I739 5.51x51 TM5 Van der Waals
JNJ-40411813 W773 6.50x50 TM6 aromatic (face-to-edge)
JNJ-40411813 W773 6.50x50 TM6 Van der Waals
JNJ-40411813 F776 6.53x53 TM6 Van der Waals
JNJ-40411813 F776 6.53x53 TM6 hydrophobic
JNJ-40411813 F780 6.57x57 TM6 Van der Waals
JNJ-40411813 F780 6.57x57 TM6 hydrophobic

Ligands

JNJ-40411813

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Residue Diagrams

L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
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ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
3x40 3.44x44 Y647
TM5
5x38 5.38x38 A726
5x40 5.40x40 M728
5x44 5.44x44 L732
5x47 5.47x47 N735
5x51 5.51x51 I739
TM6
6x48 6.50x50 W773
6x51 6.53x53 F776
6x55 6.57x57 F780