MC1 receptor (mshr_mouse)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC1 receptor

GENE

Mc1r (Msh-r)

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
S
T
Q
E
P
Q
K
S
L
10
                   
L
G
S
L
N
S
N
A
T
S
20
                   
H
L
G
L
A
T
N
Q
S
E
30
                   
P
W
C
L
Y
V
S
I
P
D
40
TM1              
G
L
F
L
S
L
G
L
V
S
50
                   
L
V
E
N
V
L
V
V
I
A
60
        ICL1    
I
T
K
N
R
N
L
H
S
P
70
TM2              
M
Y
Y
F
I
C
C
L
A
L
80
                   
S
D
L
M
V
S
V
S
I
V
90
                   
L
E
T
T
I
I
L
L
L
E
100
    ECL1 TM3  
A
G
I
L
V
A
R
V
A
L
110
                   
V
Q
Q
L
D
N
L
I
D
V
120
                   
L
I
C
G
S
M
V
S
S
L
130
                   
C
F
L
G
I
I
A
I
D
R
140
            ICL2
Y
I
S
I
F
Y
A
L
R
Y
150
        TM4      
H
S
I
V
T
L
P
R
A
R
160
                   
R
A
V
V
G
I
W
M
V
S
170
                   
I
V
S
S
T
L
F
I
T
Y
180
ECL2 TM5      
Y
K
H
T
A
V
L
L
C
L
190
                   
V
T
F
F
L
A
M
L
A
L
200
                   
M
A
I
L
Y
A
H
M
F
T
210
                   
R
A
C
Q
H
A
Q
G
I
A
220
        ICL3    
Q
L
H
K
R
R
R
S
I
R
230
TM6              
Q
G
F
C
L
K
G
A
A
T
240
                   
L
T
I
L
L
G
I
F
F
L
250
                   
C
W
G
P
F
F
L
H
L
L
260
          ECL3  
L
I
V
L
C
P
Q
H
P
T
270
            TM7  
C
S
C
I
F
K
N
F
N
L
280
                   
F
L
L
L
I
V
L
S
S
T
290
                   
V
D
P
L
I
Y
A
F
R
S
300
H8                
Q
E
L
R
M
T
L
K
E
V
310
C-term
L
L
C
S
W

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R N L H ICL1ECL1 I L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y K ECL2ICL3 R R R S I R ICL3ECL3 P Q H P T C S C I F K ECL3N-term M S T Q E P Q K S L L G S L N S N A T S H L G L A T N Q S E P W C L Y V S I N-termC-term L K E V L L C S W C-term P D G L F L S L G L V S L V E N V L V V I A I T K N S P M Y Y F I C C L A L S D L M V S V S I V L E T T I I L L L E A G R V A L V Q Q L D N L I D V L I C G S M V S S L C F L G I I A I D R Y I S I F Y T L P R A R R A V V G I W M V S I V S S T L F I T Y H T A V L L C L V T F F L A M L A L M A I L Y A H M F T R A C Q H A Q G I A Q L H K Q G F C L K G A A T L T I L L G I F F L C W G P F F L H L L L I V L C N F N L F L L L I V L S S T V D P L I Y A F R S Q E L R M T
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N E V L S V L G L S L F L G D P 1 C C L A L S D L M V S V S I V L E T T I 2 I G L F C L S S V M S G C I L V D I L N 3 A R R A V V G I W M V S I V S S T L F I 4 Y L I A M L A L M A L F F T V L C L L V 5 T I L L G I F F L C W G P F F L H L L L 6 L P D V T S S L V I L L L F L N F N 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

8 mutation data points available.

PHYSIOLOGICAL LIGANDS

agouti

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available