VPAC1 receptor (vipr1_rat)
FAMILY
Class B1 (Secretin) Peptide receptors VIP and PACAP receptors VPAC1 receptor
GENE
Vipr1
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Vasoactive intestinal polypeptide receptor 1, VIP-R-1, Pituitary adenylate cyclase-activating polypeptide type II receptor, PACAP type II receptor, PACAP-R-2, PACAP-R2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
R
|
P
|
P
|
S
|
P
|
P
|
H
|
V
|
R
|
10 |
W
|
L
|
C
|
V
|
L
|
A
|
G
|
A
|
L
|
A
|
20 |
C
|
A
|
L
|
R
|
P
|
A
|
G
|
S
|
Q
|
A
|
30 |
A
|
S
|
P
|
Q
|
H
|
E
|
C
|
E
|
Y
|
L
|
40 |
Q
|
L
|
I
|
E
|
I
|
Q
|
R
|
Q
|
Q
|
C
|
50 |
L
|
E
|
E
|
A
|
Q
|
L
|
E
|
N
|
E
|
T
|
60 |
T
|
G
|
C
|
S
|
K
|
M
|
W
|
D
|
N
|
L
|
70 |
T
|
C
|
W
|
P
|
T
|
T
|
P
|
R
|
G
|
Q
|
80 |
A
|
V
|
V
|
L
|
D
|
C
|
P
|
L
|
I
|
F
|
90 |
Q
|
L
|
F
|
A
|
P
|
I
|
H
|
G
|
Y
|
N
|
100 |
I
|
S
|
R
|
S
|
C
|
T
|
E
|
E
|
G
|
W
|
110 |
S
|
Q
|
L
|
E
|
P
|
G
|
P
|
Y
|
H
|
I
|
120 |
A
|
C
|
G
|
L
|
N
|
D
|
R
|
A
|
S
|
S
|
130 |
TM1 | |||||||||
L
|
D
|
E
|
Q
|
Q
|
Q
|
T
|
K
|
F
|
Y
|
140 |
N
|
T
|
V
|
K
|
T
|
G
|
Y
|
T
|
I
|
G
|
150 |
Y
|
S
|
L
|
S
|
L
|
A
|
S
|
L
|
L
|
V
|
160 |
A
|
M
|
A
|
I
|
L
|
S
|
L
|
F
|
R
|
K
|
170 |
ICL1 | TM2 | ||||||||
L
|
H
|
C
|
T
|
R
|
N
|
Y
|
I
|
H
|
M
|
180 |
H
|
L
|
F
|
M
|
S
|
F
|
I
|
L
|
R
|
A
|
190 |
T
|
A
|
V
|
F
|
I
|
K
|
D
|
M
|
A
|
L
|
200 |
ECL1 | |||||||||
F
|
N
|
S
|
G
|
E
|
I
|
D
|
H
|
C
|
S
|
210 |
TM3 | |||||||||
E
|
A
|
S
|
V
|
G
|
C
|
K
|
A
|
A
|
V
|
220 |
V
|
F
|
F
|
Q
|
Y
|
C
|
V
|
M
|
A
|
N
|
230 |
F
|
F
|
W
|
L
|
L
|
V
|
E
|
G
|
L
|
Y
|
240 |
L
|
Y
|
T
|
L
|
L
|
A
|
V
|
S
|
F
|
F
|
250 |
TM4 | |||||||||
S
|
E
|
R
|
K
|
Y
|
F
|
W
|
G
|
Y
|
I
|
260 |
L
|
I
|
G
|
W
|
G
|
V
|
P
|
S
|
V
|
F
|
270 |
I
|
T
|
I
|
W
|
T
|
V
|
V
|
R
|
I
|
Y
|
280 |
ECL2 | |||||||||
F
|
E
|
D
|
F
|
G
|
C
|
W
|
D
|
T
|
I
|
290 |
TM5 | |||||||||
I
|
N
|
S
|
S
|
L
|
W
|
W
|
I
|
I
|
K
|
300 |
A
|
P
|
I
|
L
|
L
|
S
|
I
|
L
|
V
|
N
|
310 |
F
|
V
|
L
|
F
|
I
|
C
|
I
|
I
|
R
|
I
|
320 |
ICL3 | |||||||||
L
|
V
|
Q
|
K
|
L
|
R
|
P
|
P
|
D
|
I
|
330 |
TM6 | |||||||||
G
|
K
|
N
|
D
|
S
|
S
|
P
|
Y
|
S
|
R
|
340 |
L
|
A
|
K
|
S
|
T
|
L
|
L
|
L
|
I
|
P
|
350 |
L
|
F
|
G
|
I
|
H
|
Y
|
V
|
M
|
F
|
A
|
360 |
ECL3 | TM7 | ||||||||
F
|
F
|
P
|
D
|
N
|
F
|
K
|
A
|
Q
|
V
|
370 |
K
|
M
|
V
|
F
|
E
|
L
|
V
|
V
|
G
|
S
|
380 |
F
|
Q
|
G
|
F
|
V
|
V
|
A
|
I
|
L
|
Y
|
390 |
H8 | |||||||||
C
|
F
|
L
|
N
|
G
|
E
|
V
|
Q
|
A
|
E
|
400 |
L
|
R
|
R
|
K
|
W
|
R
|
R
|
W
|
H
|
L
|
410 |
Q
|
G
|
V
|
L
|
G
|
W
|
S
|
S
|
K
|
S
|
420 |
C-term | |||||||||
Q
|
H
|
P
|
W
|
G
|
G
|
S
|
N
|
G
|
A
|
430 |
T
|
C
|
S
|
T
|
Q
|
V
|
S
|
M
|
L
|
T
|
440 |
R
|
V
|
S
|
P
|
S
|
A
|
R
|
R
|
S
|
S
|
450 |
S
|
F
|
Q
|
A
|
E
|
V
|
S
|
L
|
V
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
PHV, VIP, PACAP-27
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available