5-HT2B receptor (5ht2b_rat)
FAMILY
Class A (Rhodopsin) Aminergic receptors 5-Hydroxytryptamine receptors 5-HT2B receptor
GENE
Htr2b (Srl)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, 5-HT-2F, Serotonin receptor 2B, Stomach fundus serotonin receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
S
|
S
|
Y
|
K
|
M
|
S
|
E
|
Q
|
10 |
S
|
T
|
I
|
S
|
E
|
H
|
I
|
L
|
Q
|
K
|
20 |
T
|
C
|
D
|
H
|
L
|
I
|
L
|
T
|
D
|
R
|
30 |
S
|
G
|
L
|
K
|
A
|
E
|
S
|
A
|
A
|
E
|
40 |
E
|
M
|
K
|
Q
|
T
|
A
|
E
|
N
|
Q
|
G
|
50 |
TM1 | |||||||||
N
|
T
|
V
|
H
|
W
|
A
|
A
|
L
|
L
|
I
|
60 |
F
|
A
|
V
|
I
|
I
|
P
|
T
|
I
|
G
|
G
|
70 |
N
|
I
|
L
|
V
|
I
|
L
|
A
|
V
|
S
|
L
|
80 |
ICL1 | TM2 | ||||||||
E
|
K
|
R
|
L
|
Q
|
Y
|
A
|
T
|
N
|
Y
|
90 |
F
|
L
|
M
|
S
|
L
|
A
|
V
|
A
|
D
|
L
|
100 |
L
|
V
|
G
|
L
|
F
|
V
|
M
|
P
|
I
|
A
|
110 |
ECL1 | |||||||||
L
|
L
|
T
|
I
|
M
|
F
|
E
|
A
|
T
|
W
|
120 |
TM3 | |||||||||
P
|
L
|
P
|
L
|
A
|
L
|
C
|
P
|
A
|
W
|
130 |
L
|
F
|
L
|
D
|
V
|
L
|
F
|
S
|
T
|
A
|
140 |
S
|
I
|
M
|
H
|
L
|
C
|
A
|
I
|
S
|
L
|
150 |
D
|
R
|
Y
|
I
|
A
|
I
|
K
|
K
|
P
|
I
|
160 |
ICL2 | TM4 | ||||||||
Q
|
A
|
N
|
Q
|
C
|
N
|
S
|
R
|
T
|
T
|
170 |
A
|
F
|
V
|
K
|
I
|
T
|
V
|
V
|
W
|
L
|
180 |
I
|
S
|
I
|
G
|
I
|
A
|
I
|
P
|
V
|
P
|
190 |
ECL2 | |||||||||
I
|
K
|
G
|
I
|
E
|
A
|
D
|
V
|
V
|
N
|
200 |
A
|
H
|
N
|
I
|
T
|
C
|
E
|
L
|
T
|
K
|
210 |
TM5 | |||||||||
D
|
R
|
F
|
G
|
S
|
F
|
M
|
L
|
F
|
G
|
220 |
S
|
L
|
A
|
A
|
F
|
F
|
A
|
P
|
L
|
T
|
230 |
I
|
M
|
I
|
V
|
T
|
Y
|
F
|
L
|
T
|
I
|
240 |
H
|
A
|
L
|
R
|
K
|
K
|
A
|
Y
|
L
|
V
|
250 |
ICL3 | |||||||||
R
|
N
|
R
|
P
|
P
|
Q
|
R
|
L
|
T
|
R
|
260 |
W
|
T
|
V
|
S
|
T
|
V
|
L
|
Q
|
R
|
E
|
270 |
D
|
S
|
S
|
F
|
S
|
S
|
P
|
E
|
K
|
M
|
280 |
V
|
M
|
L
|
D
|
G
|
S
|
H
|
K
|
D
|
K
|
290 |
I
|
L
|
P
|
N
|
S
|
T
|
D
|
E
|
T
|
L
|
300 |
M
|
R
|
R
|
M
|
S
|
S
|
A
|
G
|
K
|
K
|
310 |
TM6 | |||||||||
P
|
A
|
Q
|
T
|
I
|
S
|
N
|
E
|
Q
|
R
|
320 |
A
|
S
|
K
|
V
|
L
|
G
|
I
|
V
|
F
|
L
|
330 |
F
|
F
|
L
|
L
|
M
|
W
|
C
|
P
|
F
|
F
|
340 |
I
|
T
|
N
|
V
|
T
|
L
|
A
|
L
|
C
|
D
|
350 |
ECL3 | TM7 | ||||||||
S
|
C
|
N
|
Q
|
T
|
T
|
L
|
K
|
T
|
L
|
360 |
L
|
Q
|
I
|
F
|
V
|
W
|
V
|
G
|
Y
|
V
|
370 |
S
|
S
|
G
|
V
|
N
|
P
|
L
|
I
|
Y
|
T
|
380 |
H8 | |||||||||
L
|
F
|
N
|
K
|
T
|
F
|
R
|
E
|
A
|
F
|
390 |
C-term | |||||||||
G
|
R
|
Y
|
I
|
T
|
C
|
N
|
Y
|
Q
|
A
|
400 |
T
|
K
|
S
|
V
|
K
|
V
|
L
|
R
|
K
|
C
|
410 |
S
|
S
|
T
|
L
|
Y
|
F
|
G
|
N
|
S
|
M
|
420 |
V
|
E
|
N
|
S
|
K
|
F
|
F
|
T
|
K
|
H
|
430 |
G
|
I
|
R
|
N
|
G
|
I
|
N
|
P
|
A
|
M
|
440 |
Y
|
Q
|
S
|
P
|
V
|
R
|
L
|
R
|
S
|
S
|
450 |
T
|
I
|
Q
|
S
|
S
|
S
|
I
|
I
|
L
|
L
|
460 |
N
|
T
|
F
|
L
|
T
|
E
|
N
|
D
|
G
|
D
|
470 |
K
|
V
|
E
|
D
|
Q
|
V
|
S
|
Y
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
5-hydroxytryptamine
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available