NMU1 receptor (nmur1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuromedin U receptors NMU1 receptor
GENE
NMUR1 (GPR66)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuromedin-U receptor 1, NMU-R1, G-protein coupled receptor 66, G-protein coupled receptor FM-3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
T
|
P
|
L
|
C
|
L
|
N
|
C
|
S
|
V
|
10 |
L
|
P
|
G
|
D
|
L
|
Y
|
P
|
G
|
G
|
A
|
20 |
R
|
N
|
P
|
M
|
A
|
C
|
N
|
G
|
S
|
A
|
30 |
A
|
R
|
G
|
H
|
F
|
D
|
P
|
E
|
D
|
L
|
40 |
N
|
L
|
T
|
D
|
E
|
A
|
L
|
R
|
L
|
K
|
50 |
TM1 | |||||||||
Y
|
L
|
G
|
P
|
Q
|
Q
|
T
|
E
|
L
|
F
|
60 |
M
|
P
|
I
|
C
|
A
|
T
|
Y
|
L
|
L
|
I
|
70 |
F
|
V
|
V
|
G
|
A
|
V
|
G
|
N
|
G
|
L
|
80 |
T
|
C
|
L
|
V
|
I
|
L
|
R
|
H
|
K
|
A
|
90 |
ICL1 | TM2 | ||||||||
M
|
R
|
T
|
P
|
T
|
N
|
Y
|
Y
|
L
|
F
|
100 |
S
|
L
|
A
|
V
|
S
|
D
|
L
|
L
|
V
|
L
|
110 |
L
|
V
|
G
|
L
|
P
|
L
|
E
|
L
|
Y
|
E
|
120 |
ECL1 | |||||||||
M
|
W
|
H
|
N
|
Y
|
P
|
F
|
L
|
L
|
G
|
130 |
TM3 | |||||||||
V
|
G
|
G
|
C
|
Y
|
F
|
R
|
T
|
L
|
L
|
140 |
F
|
E
|
M
|
V
|
C
|
L
|
A
|
S
|
V
|
L
|
150 |
N
|
V
|
T
|
A
|
L
|
S
|
V
|
E
|
R
|
Y
|
160 |
ICL2 | |||||||||
V
|
A
|
V
|
V
|
H
|
P
|
L
|
Q
|
A
|
R
|
170 |
TM4 | |||||||||
S
|
M
|
V
|
T
|
R
|
A
|
H
|
V
|
R
|
R
|
180 |
V
|
L
|
G
|
A
|
V
|
W
|
G
|
L
|
A
|
M
|
190 |
L
|
C
|
S
|
L
|
P
|
N
|
T
|
S
|
L
|
H
|
200 |
ECL2 | |||||||||
G
|
I
|
R
|
Q
|
L
|
H
|
V
|
P
|
C
|
R
|
210 |
G
|
P
|
V
|
P
|
D
|
S
|
A
|
V
|
C
|
M
|
220 |
TM5 | |||||||||
L
|
V
|
R
|
P
|
R
|
A
|
L
|
Y
|
N
|
M
|
230 |
V
|
V
|
Q
|
T
|
T
|
A
|
L
|
L
|
F
|
F
|
240 |
C
|
L
|
P
|
M
|
A
|
I
|
M
|
S
|
V
|
L
|
250 |
Y
|
L
|
L
|
I
|
G
|
L
|
R
|
L
|
R
|
R
|
260 |
E
|
R
|
L
|
L
|
L
|
M
|
Q
|
E
|
A
|
K
|
270 |
ICL3 | |||||||||
G
|
R
|
G
|
S
|
A
|
A
|
A
|
R
|
S
|
R
|
280 |
TM6 | |||||||||
Y
|
T
|
C
|
R
|
L
|
Q
|
Q
|
H
|
D
|
R
|
290 |
G
|
R
|
R
|
Q
|
V
|
T
|
K
|
M
|
L
|
F
|
300 |
V
|
L
|
V
|
V
|
V
|
F
|
G
|
I
|
C
|
W
|
310 |
A
|
P
|
F
|
H
|
A
|
D
|
R
|
V
|
M
|
W
|
320 |
ECL3 | TM7 | ||||||||
S
|
V
|
V
|
S
|
Q
|
W
|
T
|
D
|
G
|
L
|
330 |
H
|
L
|
A
|
F
|
Q
|
H
|
V
|
H
|
V
|
I
|
340 |
S
|
G
|
I
|
F
|
F
|
Y
|
L
|
G
|
S
|
A
|
350 |
A
|
N
|
P
|
V
|
L
|
Y
|
S
|
L
|
M
|
S
|
360 |
H8 | |||||||||
S
|
R
|
F
|
R
|
E
|
T
|
F
|
Q
|
E
|
A
|
370 |
L
|
C
|
L
|
G
|
A
|
C
|
C
|
H
|
R
|
L
|
380 |
C-term | |||||||||
R
|
P
|
R
|
H
|
S
|
S
|
H
|
S
|
L
|
S
|
390 |
R
|
M
|
T
|
T
|
G
|
S
|
T
|
L
|
C
|
D
|
400 |
V
|
G
|
S
|
L
|
G
|
S
|
W
|
V
|
H
|
P
|
410 |
L
|
A
|
G
|
N
|
D
|
G
|
P
|
E
|
A
|
Q
|
420 |
Q
|
E
|
T
|
D
|
P
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neuromedin U-25, neuromedin S-36, neuromedin S-33, neuromedin U-23
STRUCTURE MODELS
STRUCTURES
Found 2 structure(s) - view all details on the Structures page