NMU1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7W56

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41467-022-29683-W

PUBLICATION DATE

April 20, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

79 interactions (Click to see)

LIGANDS

Neuromedin-S - Agonist

PHYSIOLOGICAL LIGANDS

neuromedin U-25, neuromedin S-36, neuromedin S-33, neuromedin U-23



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 T 93 2x37 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 93 2x37 G.H5 E 357 G.H5.22
Polar TM6 R 292 6x30 G.H5 Q 352 G.H5.17
Van-der-waals TM6 R 292 6x30 G.H5 Q 352 G.H5.17
Hydrophobic TM3 A 162 3x53 G.H5 L 355 G.H5.20
Hydrophobic ICL2 P 166 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 I 350 G.H5.15
Hydrophobic TM6 R 292 6x30 G.H5 V 361 G.H5.26
Van-der-waals TM6 R 292 6x30 G.H5 V 361 G.H5.26
Hydrophobic ICL2 R 170 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 170 34x54 G.hns1 R 32 G.hns1.03
Polar H8 S 361 8x48 G.H5 R 356 G.H5.21
Hydrophobic H8 R 362 8x49 G.H5 R 356 G.H5.21
Van-der-waals H8 R 362 8x49 G.H5 R 356 G.H5.21
Hydrophobic ICL2 M 172 34x56 G.H5 Y 358 G.H5.23
Van-der-waals ICL2 M 172 34x56 G.H5 Y 358 G.H5.23
Hydrophobic TM5 L 258 5x65 G.H5 L 351 G.H5.16
Hydrophobic TM2 T 95 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 T 95 2x39 G.H5 Y 358 G.H5.23
Polar H8 S 360 8x47 G.H5 N 359 G.H5.24
Hydrophobic H8 S 360 8x47 G.H5 N 359 G.H5.24
Van-der-waals H8 S 360 8x47 G.H5 N 359 G.H5.24
Hydrophobic TM3 V 161 3x52 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 M 172 34x56 G.H5 E 357 G.H5.22
Van-der-waals ICL2 M 172 34x56 G.H5 E 357 G.H5.22
Ionic H8 E 365 8x52 G.H5 R 356 G.H5.21
Polar H8 E 365 8x52 G.H5 R 356 G.H5.21
Hydrophobic H8 E 365 8x52 G.H5 R 356 G.H5.21
Van-der-waals H8 E 365 8x52 G.H5 R 356 G.H5.21
Polar ICL2 Q 168 34x52 G.H5 N 354 G.H5.19
Hydrophobic ICL2 Q 168 34x52 G.H5 N 354 G.H5.19
Van-der-waals ICL2 Q 168 34x52 G.H5 N 354 G.H5.19
Polar ICL2 A 169 34x53 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 169 34x53 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 A 169 34x53 G.hns1 R 31 G.hns1.02
Polar ICL2 Q 168 34x52 G.H5 E 357 G.H5.22
Van-der-waals ICL2 Q 168 34x52 G.H5 E 357 G.H5.22
Hydrophobic TM3 H 165 3x56 G.H5 I 350 G.H5.15
Van-der-waals TM3 H 165 3x56 G.H5 I 350 G.H5.15
Hydrophobic TM5 L 258 5x65 G.H5 L 355 G.H5.20
Hydrophobic TM4 T 174 4x38 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 T 174 4x38 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 Q 168 34x52 G.H5 Y 358 G.H5.23
Van-der-waals ICL2 Q 168 34x52 G.H5 Y 358 G.H5.23
Polar H8 R 362 8x49 G.H5 E 357 G.H5.22
Hydrophobic H8 R 362 8x49 G.H5 E 357 G.H5.22
Van-der-waals H8 R 362 8x49 G.H5 E 357 G.H5.22
Hydrophobic ICL2 V 173 34x57 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 V 173 34x57 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 159 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 R 159 3x50 G.H5 L 360 G.H5.25
Van-der-waals TM3 H 165 3x56 G.H5 N 354 G.H5.19
Polar H8 S 360 8x47 G.H5 V 361 G.H5.26
Hydrophobic H8 S 360 8x47 G.H5 V 361 G.H5.26
Van-der-waals H8 S 360 8x47 G.H5 V 361 G.H5.26
Hydrophobic TM3 L 155 3x46 G.H5 Y 358 G.H5.23
Hydrophobic TM3 H 165 3x56 G.H5 K 347 G.H5.12
Van-der-waals TM3 H 165 3x56 G.H5 K 347 G.H5.12
Hydrophobic TM6 L 299 6x37 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 299 6x37 G.H5 L 360 G.H5.25
Polar H8 S 361 8x48 G.H5 V 361 G.H5.26
Hydrophobic H8 S 361 8x48 G.H5 V 361 G.H5.26
Van-der-waals H8 S 361 8x48 G.H5 V 361 G.H5.26
Hydrophobic H8 F 363 8x50 G.H5 N 359 G.H5.24
Van-der-waals H8 F 363 8x50 G.H5 N 359 G.H5.24
Hydrophobic TM6 V 295 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 V 295 6x33 G.H5 L 360 G.H5.25
Polar TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 Y 358 G.H5.23
Polar TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Hydrophobic TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 E 158 3x49 G.H5 Y 358 G.H5.23
Polar ICL2 R 170 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 170 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 170 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM6 V 295 6x33 G.H5 V 361 G.H5.26
Van-der-waals TM6 V 295 6x33 G.H5 V 361 G.H5.26
Hydrophobic TM2 L 99 2x43 G.H5 N 359 G.H5.24
Van-der-waals TM2 L 99 2x43 G.H5 N 359 G.H5.24
Hydrophobic TM2 Y 98 2x42 G.H5 Y 358 G.H5.23
Polar TM2 T 95 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM2 T 95 2x39 G.H5 E 357 G.H5.22
Van-der-waals TM2 T 95 2x39 G.H5 E 357 G.H5.22
Hydrophobic TM3 A 162 3x53 G.H5 L 351 G.H5.16
Van-der-waals TM3 A 162 3x53 G.H5 L 351 G.H5.16