GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

April 13, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

(-)-noradrenaline - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

(-)-noradrenaline, (-)-adrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 L 158 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 I 154 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Aromatic TM6 R 383 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 383 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 241 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 154 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM5 R 241 5x68 G.H5 A 345 G.H5.17
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20
Ionic TM6 R 380 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 380 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 383 6x29 G.h4s6 N 316 G.h4s6.10
Hydrophobic ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23