TA1 receptor (taar1_mouse)
FAMILY
Class A (Rhodopsin) Aminergic receptors Trace amine receptors TA1 receptor
GENE
Taar1 (Ta1, Tar1, Trar1)
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
H
|
L
|
C
|
H
|
A
|
I
|
T
|
N
|
I
|
10 |
S
|
H
|
R
|
N
|
S
|
D
|
W
|
S
|
R
|
E
|
20 |
TM1 | |||||||||
V
|
Q
|
A
|
S
|
L
|
Y
|
S
|
L
|
M
|
S
|
30 |
L
|
I
|
I
|
L
|
A
|
T
|
L
|
V
|
G
|
N
|
40 |
L
|
I
|
V
|
I
|
I
|
S
|
I
|
S
|
H
|
F
|
50 |
ICL1 | TM2 | ||||||||
K
|
Q
|
L
|
H
|
T
|
P
|
T
|
N
|
W
|
L
|
60 |
L
|
H
|
S
|
M
|
A
|
I
|
V
|
D
|
F
|
L
|
70 |
L
|
G
|
C
|
L
|
I
|
M
|
P
|
C
|
S
|
M
|
80 |
ECL1 | |||||||||
V
|
R
|
T
|
V
|
E
|
R
|
C
|
W
|
Y
|
F
|
90 |
TM3 | |||||||||
G
|
E
|
I
|
L
|
C
|
K
|
V
|
H
|
T
|
S
|
100 |
T
|
D
|
I
|
M
|
L
|
S
|
S
|
A
|
S
|
I
|
110 |
F
|
H
|
L
|
A
|
F
|
I
|
S
|
I
|
D
|
R
|
120 |
ICL2 | |||||||||
Y
|
C
|
A
|
V
|
C
|
D
|
P
|
L
|
R
|
Y
|
130 |
TM4 | |||||||||
K
|
A
|
K
|
I
|
N
|
I
|
S
|
T
|
I
|
L
|
140 |
V
|
M
|
I
|
L
|
V
|
S
|
W
|
S
|
L
|
P
|
150 |
A
|
V
|
Y
|
A
|
F
|
G
|
M
|
I
|
F
|
L
|
160 |
ECL2 | |||||||||
E
|
L
|
N
|
L
|
K
|
G
|
V
|
E
|
E
|
L
|
170 |
Y
|
R
|
S
|
Q
|
V
|
S
|
D
|
L
|
G
|
G
|
180 |
TM5 | |||||||||
C
|
S
|
P
|
F
|
F
|
S
|
K
|
V
|
S
|
G
|
190 |
V
|
L
|
A
|
F
|
M
|
T
|
S
|
F
|
Y
|
I
|
200 |
P
|
G
|
S
|
V
|
M
|
L
|
F
|
V
|
Y
|
Y
|
210 |
R
|
I
|
Y
|
F
|
I
|
A
|
K
|
G
|
Q
|
A
|
220 |
R
|
S
|
I
|
N
|
R
|
T
|
N
|
V
|
Q
|
V
|
230 |
ICL3 | TM6 | ||||||||
G
|
L
|
E
|
G
|
K
|
S
|
Q
|
A
|
P
|
Q
|
240 |
S
|
K
|
E
|
T
|
K
|
A
|
A
|
K
|
T
|
L
|
250 |
G
|
I
|
M
|
V
|
G
|
V
|
F
|
L
|
V
|
C
|
260 |
W
|
C
|
P
|
F
|
F
|
L
|
C
|
T
|
V
|
L
|
270 |
ECL3 | |||||||||
D
|
P
|
F
|
L
|
G
|
Y
|
V
|
I
|
P
|
P
|
280 |
TM7 | |||||||||
S
|
L
|
N
|
D
|
A
|
L
|
Y
|
W
|
F
|
G
|
290 |
Y
|
L
|
N
|
S
|
A
|
L
|
N
|
P
|
M
|
V
|
300 |
H8 | |||||||||
Y
|
A
|
F
|
F
|
Y
|
P
|
W
|
F
|
R
|
R
|
310 |
A
|
L
|
K
|
M
|
V
|
L
|
L
|
G
|
K
|
I
|
320 |
C-term | |||||||||
F
|
Q
|
K
|
D
|
S
|
S
|
R
|
S
|
K
|
L
|
330 |
F
|
L
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
3-iodothyronamine, β-phenylethylamine, tyramine
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).