GPR35 (gpr35_mouse)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans GPR35

GENE

Gpr35

ORGANISM

Mouse (Mus musculus)

ALT. NAMES

G-protein coupled receptor 35, Kynurenic acid receptor, KYNA receptor

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
S
T
T
C
N
S
T
L
10
    TM1          
T
W
P
A
S
V
N
N
F
F
20
                   
I
I
Y
S
A
L
L
L
V
L
30
                   
G
L
L
L
N
S
V
A
L
W
40
          ICL1  
V
F
C
Y
R
M
H
Q
W
T
50
TM2              
E
T
R
I
Y
M
T
N
L
A
60
                   
V
A
D
L
C
L
L
C
S
L
70
            ECL1
P
F
V
L
Y
S
L
K
Y
S
80
      TM3        
S
S
D
T
P
V
C
Q
L
S
90
                   
Q
G
I
Y
L
A
N
R
Y
M
100
                   
S
I
S
L
V
T
A
I
A
V
110
                   
D
R
Y
V
A
V
R
H
P
L
120
ICL2     TM4  
R
A
R
E
L
R
S
P
R
Q
130
                   
A
A
A
V
C
V
A
L
W
V
140
                   
I
V
V
T
S
L
V
V
R
W
150
            ECL2
R
L
G
M
Q
E
G
G
F
C
160
                   
F
S
S
Q
T
R
R
N
F
S
170
  TM5            
T
T
A
F
S
L
L
G
F
Y
180
                   
L
P
L
A
I
V
V
F
C
S
190
                   
L
Q
V
V
T
V
L
S
R
R
200
ICL3 TM6      
P
A
A
D
V
G
Q
A
E
A
210
                   
T
Q
K
A
T
H
M
V
W
A
220
                   
N
L
A
V
F
V
I
C
F
L
230
                   
P
L
H
V
V
L
T
V
Q
V
240
    ECL3   TM7
S
L
N
L
N
T
C
A
A
R
250
                   
D
T
F
S
R
A
L
S
I
T
260
                   
G
K
L
S
D
T
N
C
C
L
270
                H8
D
A
I
C
Y
Y
Y
M
A
R
280
                   
E
F
Q
E
A
S
K
P
A
T
290
C-term        
S
S
N
T
P
H
K
S
Q
D
300
             
S
Q
I
L
S
L
T

LINKS

DIAGRAMS

7TM

ICL1 M H Q W ICL1ECL1 L K Y S S S D ECL1ICL2 P L R A R E L R ICL2ECL2 G G F C F S S Q T R R N F S T ECL2ICL3 P A A ICL3ECL3 N L N T C ECL3N-term M N S T T C N S T L T W N-termC-term T S S N T P H K S Q D S Q I L S L T C-term P A S V N N F F I I Y S A L L L V L G L L L N S V A L W V F C Y R T E T R I Y M T N L A V A D L C L L C S L P F V L Y S T P V C Q L S Q G I Y L A N R Y M S I S L V T A I A V D R Y V A V R H S P R Q A A A V C V A L W V I V V T S L V V R W R L G M Q E T A F S L L G F Y L P L A I V V F C S L Q V V T V L S R R D V G Q A E A T Q K A T H M V W A N L A V F V I C F L P L H V V L T V Q V S L A A R D T F S R A L S I T G K L S D T N C C L D A I C Y Y Y M A R E S K P F Q E A A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

S N L L L G L V L L L A S Y I I F F N N 1 T N L A V A D L C L L C S L P F V L Y S 2 A T V L S I S M Y R N A L Y I G Q S L Q 3 A A A V C V A L W V I V V T S L V V R W 4 S C F V V I A L P L Y F G L L S F A T 5 W A N L A V F V I C F L P L H V V L T V 6 I A D L C C N T D S L K G T I S L A R 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

PHYSIOLOGICAL LIGANDS

kynurenic acid

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available