GPR35 (gpr35_mouse)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans GPR35
GENE
Gpr35
ORGANISM
Mouse (Mus musculus)
ALT. NAMES
G-protein coupled receptor 35, Kynurenic acid receptor, KYNA receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
N
|
S
|
T
|
T
|
C
|
N
|
S
|
T
|
L
|
10 |
TM1 | |||||||||
T
|
W
|
P
|
A
|
S
|
V
|
N
|
N
|
F
|
F
|
20 |
I
|
I
|
Y
|
S
|
A
|
L
|
L
|
L
|
V
|
L
|
30 |
G
|
L
|
L
|
L
|
N
|
S
|
V
|
A
|
L
|
W
|
40 |
ICL1 | |||||||||
V
|
F
|
C
|
Y
|
R
|
M
|
H
|
Q
|
W
|
T
|
50 |
TM2 | |||||||||
E
|
T
|
R
|
I
|
Y
|
M
|
T
|
N
|
L
|
A
|
60 |
V
|
A
|
D
|
L
|
C
|
L
|
L
|
C
|
S
|
L
|
70 |
ECL1 | |||||||||
P
|
F
|
V
|
L
|
Y
|
S
|
L
|
K
|
Y
|
S
|
80 |
TM3 | |||||||||
S
|
S
|
D
|
T
|
P
|
V
|
C
|
Q
|
L
|
S
|
90 |
Q
|
G
|
I
|
Y
|
L
|
A
|
N
|
R
|
Y
|
M
|
100 |
S
|
I
|
S
|
L
|
V
|
T
|
A
|
I
|
A
|
V
|
110 |
D
|
R
|
Y
|
V
|
A
|
V
|
R
|
H
|
P
|
L
|
120 |
ICL2 | TM4 | ||||||||
R
|
A
|
R
|
E
|
L
|
R
|
S
|
P
|
R
|
Q
|
130 |
A
|
A
|
A
|
V
|
C
|
V
|
A
|
L
|
W
|
V
|
140 |
I
|
V
|
V
|
T
|
S
|
L
|
V
|
V
|
R
|
W
|
150 |
ECL2 | |||||||||
R
|
L
|
G
|
M
|
Q
|
E
|
G
|
G
|
F
|
C
|
160 |
F
|
S
|
S
|
Q
|
T
|
R
|
R
|
N
|
F
|
S
|
170 |
TM5 | |||||||||
T
|
T
|
A
|
F
|
S
|
L
|
L
|
G
|
F
|
Y
|
180 |
L
|
P
|
L
|
A
|
I
|
V
|
V
|
F
|
C
|
S
|
190 |
L
|
Q
|
V
|
V
|
T
|
V
|
L
|
S
|
R
|
R
|
200 |
ICL3 | TM6 | ||||||||
P
|
A
|
A
|
D
|
V
|
G
|
Q
|
A
|
E
|
A
|
210 |
T
|
Q
|
K
|
A
|
T
|
H
|
M
|
V
|
W
|
A
|
220 |
N
|
L
|
A
|
V
|
F
|
V
|
I
|
C
|
F
|
L
|
230 |
P
|
L
|
H
|
V
|
V
|
L
|
T
|
V
|
Q
|
V
|
240 |
ECL3 | TM7 | ||||||||
S
|
L
|
N
|
L
|
N
|
T
|
C
|
A
|
A
|
R
|
250 |
D
|
T
|
F
|
S
|
R
|
A
|
L
|
S
|
I
|
T
|
260 |
G
|
K
|
L
|
S
|
D
|
T
|
N
|
C
|
C
|
L
|
270 |
H8 | |||||||||
D
|
A
|
I
|
C
|
Y
|
Y
|
Y
|
M
|
A
|
R
|
280 |
E
|
F
|
Q
|
E
|
A
|
S
|
K
|
P
|
A
|
T
|
290 |
C-term | |||||||||
S
|
S
|
N
|
T
|
P
|
H
|
K
|
S
|
Q
|
D
|
300 |
S
|
Q
|
I
|
L
|
S
|
L
|
T
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
kynurenic acid
STRUCTURE MODELS
No structure models available. Check the Archive on Structure models for earlier releases.
STRUCTURES
No structures available